DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3841 and CES3

DIOPT Version :9

Sequence 1:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_079198.2	Gene:	CES3 / 23491	HGNCID:	1865	Length:	571	Species:	Homo sapiens

Alignment Length:	561	Identity:	167/561 - (29%)
Similarity:	249/561 - (44%)	Gaps:	90/561 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PVVELSLGRIQGDTMQSFG-NKTIYAFRGIRYAQSPVGQLRFANPVPETSWGDEVFNATSDSLVC 92
            |.|:.:|||::|..:...| ::.:..|.||.:||.|:|..||:.|.|...| :.|.:|::...:|
Human    34 PEVDTTLGRVRGRQVGVKGTDRLVNVFLGIPFAQPPLGPDRFSAPHPAQPW-EGVRDASTAPPMC 97

  Fly    93 PQPGVVSL---------------MSEDCLKINVFTKS---FEDKFPVMVYIHGGANVLGSGHSSY 139
            .| .|.|:               :|||||.:||::.:   .....||||::||||.:.|:. :||
Human    98 LQ-DVESMNSSRFVLNGKQQIFSVSEDCLVLNVYSPAEVPAGSGRPVMVWVHGGALITGAA-TSY 160

  Fly   140 EAGPQYLLDQDVVFVAFNYRLGALGFLSTNSSETKGNFGFLDQVMALEWVRDHISHFGGDPELVT 204
            : |.......|||.|...||||.|||.||......||.||||.|.||.||:::|:.||||...||
Human   161 D-GSALAAYGDVVVVTVQYRLGVLGFFSTGDEHAPGNQGFLDVVAALRWVQENIAPFGGDLNCVT 224

  Fly   205 IIGISAGSMAVSLHLASPLSAGLFHRAILMSGSATNHFDIDNLFW--TRKLARELGCPMYDPTDV 267
            :.|.|||...:|..:.||::||||||||..||..|....||:..|  .:|:|..|.|....|.::
Human   225 VFGGSAGGSIISGLVLSPVAAGLFHRAITQSGVITTPGIIDSHPWPLAQKIANTLACSSSSPAEM 289

  Fly   268 VECLRNETWTRIVEVCKAWETYQLVNMKWNYEIDGHFLHNHPTELIKEGNFNKVPLLISFTANEF 332
            |:||:.:....:|      .:.:|.|..:...:||......|.||:||..|:.||.|:....:||
Human   290 VQCLQQKEGEELV------LSKKLKNTIYPLTVDGTVFPKSPKELLKEKPFHSVPFLMGVNNHEF 348

  Fly   333 -----------DYNANVHLENQHLLHDFASNFVDYAPELFLYRHDAQIGEKLKDFYLGDNTTEIN 386
                       |....:..|:...:.......:|..||:.         ..:.|.|||.|:..
Human   349 SWLIPRGWGLLDTMEQMSREDMLAISTPVLTSLDVPPEMM---------PTVIDEYLGSNSDA-- 402

  Fly   387 SENIENFGQIFSDAYIG-HGVHRLVQLASHFTPVYYTRMDYVGDQSLSAPLN-GENKP--VGVGH 447
            ....:.|.:...|.:|. ..|.....|....:||::....:       .|.: .:.||  |...|
Human   403 QAKCQAFQEFMGDVFINVPTVSFSRYLRDSGSPVFFYEFQH-------RPSSFAKIKPAWVKADH 460

  Fly   448 ADDLHYVLPGYWYGPLM-----------AANDSDVFMMERLTSWFTHFAKTGTPLNSTDI--WPP 499
            ..:..:|    :.||.:           |..:.....:..:..| ||||:||.| ||..:  ||.
Human   461 GAEGAFV----FGGPFLMDESSRLAFPEATEEEKQLSLTMMAQW-THFARTGDP-NSKALPPWPQ 519

  Fly   500 CNSTVLKMLYNGVVTQVGSPGYSNRYA---VWDKLFPTAAQ 537
            .|.....:..|    .|...|...|.|   .|.:..|:..|
Human   520 FNQAEQYLEIN----PVPRAGQKFREAWMQFWSETLPSKIQ 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	164/550 (30%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	58/118 (49%)
CES3	NP_079198.2	COesterase	32..547	CDD:278561	164/550 (30%)
		Aes	<129..>247	CDD:223730	52/119 (44%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142619
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D233524at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750