DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3841 and Ces4a

DIOPT Version :9

Sequence 1:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_666325.2	Gene:	Ces4a / 234677	MGIID:	2384581	Length:	563	Species:	Mus musculus

Alignment Length:	571	Identity:	175/571 - (30%)
Similarity:	264/571 - (46%)	Gaps:	63/571 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FQLTWALLLILIGFTTAVTFIG----DDPVVELSLGRIQGDTMQSFGNKTIYAFRGIRYAQSPVG 65
            :.:.|.|.|.|.......|.:|    .:|::....|.:||..:. .|:..|..|.||.:::.|||
Mouse     6 WNMKWILGLSLTLCLVVQTALGALHTKEPLLITKHGILQGKQVH-VGDTPIQVFLGIPFSKPPVG 69

  Fly    66 QLRFANPVPETSWGDEVFNATSDSLVCPQPG---VVSL------------MSEDCLKINVFTKSF 115
            ..|||.|.|...| :.:.:||:....|.|..   ::|:            .|||||.:||:....
Mouse    70 TRRFAPPEPPLPW-NGIRDATTYPPSCLQESWGQILSMYLNTRKQYKWLHFSEDCLYLNVYAPVL 133

  Fly   116 ---EDKFPVMVYIHGGANVLGSGHSSYEAGPQYLLDQDVVFVAFNYRLGALGFLSTNSSETKGNF 177
               ....||||:..|||.:.||. |:|| |.:......||.|...||||.|||.||.:|..:||:
Mouse   134 APGAPLLPVMVWFPGGAFLAGSA-STYE-GSELAARGKVVLVFLQYRLGILGFFSTGNSHARGNW 196

  Fly   178 GFLDQVMALEWVRDHISHFGGDPELVTIIGISAGSMAVSLHLASPLSAGLFHRAILMSGSATNHF 242
            |.|||:.||.||:::|..|||||:.||:.|.|||:|:||..:.|||:.||||:||..||:|....
Mouse   197 GLLDQIAALRWVQENIEAFGGDPDSVTLFGQSAGAMSVSGLMVSPLAQGLFHQAISQSGTAVLKA 261

  Fly   243 DI--DNLFWTRKLARELGCPMYDPTDVVECLRNETWTRIVEVCKAWETYQLVNMKWNYEI----- 300
            .|  |.|...:|:|...||.......:|||||:.:...:..|.|....:|..:.|...||
Mouse   262 FITPDPLTSAKKIAHLAGCDHNSTKVMVECLRSLSAEEVTLVSKRMSFFQANSHKDPKEIVWFLS 326

  Fly   301 ---DGHFLHNHPTELIKEGNFNKVPLLISFTANEFDYNANVHLE---NQHLLHDFASNFVDYAPE 359
               ||......|..|:..|....||.|:.....||::|....::   ||.:::....|.:.::..
Mouse   327 PVVDGVVFPEDPVVLLTRGQVKPVPYLLGVNNAEFEWNLPFLMKIQLNQRMMNQTNINKILWSFN 391

  Fly   360 LFLYRHDAQIGEKLKDFYLGDNTTEINSENIENFGQIFSDAYIGHG--VHRLVQLASHF----TP 418
            :.|.....|:....:: ||.|   .|::.:.:.|.....| .||..  |:..:|.|.:.    :|
Mouse   392 VLLNITKEQVPVVARE-YLND---AISNHDWKMFRNRLID-LIGDATFVYATLQAARYHRDAGSP 451

  Fly   419 VY-YTRMDYVGDQSLSAPLNGENKPVGVGHADDLHYVLPGYWYGPLMAANDSDVFMMERLTSWFT 482
            || |....:.....:..|.||.:      |.|:|.|:. |..:....:|.:...|.::.:..| .
Mouse   452 VYLYEFKHHASSGIIIKPYNGAD------HGDELSYLF-GSPFSKGSSAGEEKEFSLQMMKYW-A 508

  Fly   483 HFAKTGTPLNSTDI--WPPCNSTVLKMLYNGVVTQVGSPGYSNRYAVWDKL 531
            :||.||.| |...:  ||..:... |.|.....|:||......:.|.|.:|
Mouse   509 NFAHTGNP-NGEKLPYWPRFDKDE-KYLQLDFDTRVGVKLKEKKMAFWSQL 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	167/540 (31%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	60/118 (51%)
Ces4a	NP_666325.2	COesterase	30..554	CDD:278561	167/542 (31%)
Ces4a	NP_666325.2	Aes	<128..>272	CDD:223730	67/145 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832834
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	228	1.000	Inparanoid score	I3450
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.790