DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3841 and Ces2c

DIOPT Version :9

Sequence 1:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_663578.1	Gene:	Ces2c / 234671	MGIID:	2385905	Length:	561	Species:	Mus musculus

Alignment Length:	576	Identity:	173/576 - (30%)
Similarity:	271/576 - (47%)	Gaps:	88/576 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 WALLLILIGFTTAVTFIGDD-----PVVELSLGRIQGDTMQSFGNKT-IYAFRGIRYAQSPVGQL 67
            :.|||:||...      |.|     |:.....|:|||..:.....|. ::.|.||.:|:.|||.|
Mouse    15 FGLLLLLIHVQ------GQDSPEANPIRNTHTGQIQGSLIHVKDTKAGVHTFLGIPFAKPPVGPL 73

  Fly    68 RFANPVPETSWGDEVFNATSDSLVCPQ----------PGVVSL-----MSEDCLKINVFTKSFE- 116
            |||.|.....|.. |.:.|:...:|.|          |.:..:     ||||||.:|::|.:..
Mouse    74 RFAPPEAPEPWSG-VRDGTAHPAMCLQNLDMLNEAGLPDMKMMLSSFPMSEDCLYLNIYTPAHAH 137

  Fly   117 --DKFPVMVYIHGGANVLGSGHSSYEAGPQYLLDQDVVFVAFNYRLGALGFLSTNSSETKGNFGF 179
              ...||||:|||||.|:|.  :|...|....:::|:|.|...||||.|||.||.....:||:|:
Mouse   138 EGSNLPVMVWIHGGALVIGM--ASMFDGSLLTVNEDLVVVTIQYRLGVLGFFSTGDQHARGNWGY 200

  Fly   180 LDQVMALEWVRDHISHFGGDPELVTIIGISAGSMAVSLHLASPLSAGLFHRAILMSGSATNHFDI 244
            |||..||.||:.:|:||||:|:.|||.|.|||..:||.|:.||:|.||||.||:.||.|.    :
Mouse   201 LDQAAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSHVVSPMSQGLFHGAIMESGVAL----L 261

  Fly   245 DNL------FWTRKLARELGCPMYDPTDVVECLRNETWTRIVEVCKAWETYQLVNMKWNYEIDGH 303
            .:|      ..:..:|:..||...|...:|.|||.::...|:.:.|.::....|       :||.
Mouse   262 PDLISETSEMVSTTVAKLSGCEAMDSQALVRCLRGKSEAEILAINKVFKMIPAV-------VDGE 319

  Fly   304 FLHNHPTELIKEGNFNKVPLLISFTANEFDYNANVHLENQHLL-----HDFASNFVDYAPELFLY 363
            |...||.||:...:|:.||.:|....:||.::..|.:.:..::     .:..:...|.|.::.|
Mouse   320 FFPRHPKELLASEDFHPVPSIIGVNNDEFGWSIPVVMGSAQMIKGITRENLQAVLKDTAVQMML- 383

  Fly   364 RHDAQIGEKLKDFYLGDNTTEINSENIENFGQIFSDAYIGHGVHRLVQLASHF----TPVYYTRM 424
              ..:..:.|.:.|:|| |.:..:..|: |.::..|...   |...:|:| ||    .|||:...
Mouse   384 --PPECSDLLMEEYMGD-TEDAQTLQIQ-FTEMMGDFMF---VIPALQVA-HFQRSHAPVYFYEF 440

  Fly   425 ----DYVGDQSLSAPLNGENKP--VGVGHADDLHYVLPGYWYGPLMAANDSDVFMMERLTSWFTH 483
                .|..|.          :|  |...|||::.:|...:::|..:...:.:..:..|:..::.:
Mouse   441 QHPPSYFKDV----------RPPHVKADHADEIPFVFASFFWGMKLDFTEEEELLSRRMMKYWAN 495

  Fly   484 FAKTGTPLNSTDI--WPPCNSTVLKMLYNGVVTQVGSPGYSNRYAVWDKLFPTAAQ 537
            ||:.|.| ||..:  ||..:... :.|...:...||....:.|...|.|..|...|
Mouse   496 FARHGNP-NSEGLPYWPVMDHDE-QYLQLDIQPAVGRALKAGRLQFWTKTLPQKIQ 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	163/547 (30%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	60/121 (50%)
Ces2c	NP_663578.1	COesterase	31..540	CDD:278561	162/543 (30%)
		Aes	<130..>233	CDD:223730	48/104 (46%)
		Prevents secretion from ER. /evidence=ECO:0000255	558..561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832713
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	228	1.000	Inparanoid score	I3450
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D233524at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.800