Protein Alignment CG3841 and NLGN1

DIOPT Version :10

• Sequence 1: NP_609300.1
• Gene: CG3841 / 34278
• FlyBaseID: FBgn0032131
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Alignment Length: 639
• Identity: 176/639 - (27%)
• Similarity: 265/639 - (41%)
• Gaps: 148/639 - (23%)

  Fly     7 LTWALL--LILIGFTTAVTFIGDDPVVELSLGRIQGDTMQSFGNK---TIYAFRGIRYAQSPVGQ 66
            ||..:|  |:..|...:......||:|..:.|:|:| ..:...|:   .:..|.|:.||..|.|:
Human    29 LTLCMLGCLLQAGHVLSQKLDDVDPLVATNFGKIRG-IKKELNNEILGPVIQFLGVPYAAPPTGE 92

  Fly    67 LRFANPVPETSWGDEVFNATSDSLVCPQ-------PGV----------------VSLMSEDCLKI 108
            .||..|.|.:.|.| :.|||..:.||||       |.|                |...|||||.:
Human    93 RRFQPPEPPSPWSD-IRNATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYL 156

  Fly   109 NVF--------TKSFEDKF------------------PVMVYIHGGANVLGSGH-------SSYE 140
            |::        ||...|..                  |||||||||:.:.|:|:       :||
Human   157 NIYVPTEDGPLTKKQTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLASY- 220

  Fly   141 AGPQYLLDQDVVFVAFNYRLGALGFLSTNSSETKGNFGFLDQVMALEWVRDHISHFGGDPELVTI 205
                    .:|:.:..|||||.||||||.....|||:|.||.:.||.|..::|..|||||..:|:
Human   221 --------GNVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITV 277

  Fly   206 IGISAGSMAVSLHLASPLS---------AGLFHRAILMSGSATNHFDIDNLF----WTRKLAREL 257
            .|..||...|:|...|..|         .|||.|||..||:|.:.:.:.  |    :.|.||.::
Human   278 FGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVS--FQPAKYARMLATKV 340

  Fly   258 GCPMYDPTDVVECLRNETWTRIVEVCKAWETYQLVNMKWNYEIDGHFLHNHPTELIKEGNFNKVP 322
            ||.:.|..::||||:.:.:..:|:.......|.:.   :...|||..:.:.|..|:::|.|....
Human   341 GCNVSDTVELVECLQKKPYKELVDQDIQPARYHIA---FGPVIDGDVIPDDPQILMEQGEFLNYD 402

  Fly   323 LL--------ISFTANEFDYNANVHLENQHLLHDFA-SNFVDYAPELFLYRHDAQIGEKLKDFYL 378
            ::        :.|..|..|.:..:...:    .||| |||||   .|:.|.....:..:...|..
Human   403 IMLGVNQGEGLKFVENIVDSDDGISASD----FDFAVSNFVD---NLYGYPEGKDVLRETIKFMY 460

  Fly   379 GDNTTEINSE-NIENFGQIFSDAYIGHGVHRLV-------QLASHF-TPVYYTRMDYVGDQSLSA 434
            .|.....|.| ..:....:|:|       |:.|       .|.|:| :|.|:... |...|:...
Human   461 TDWADRHNPETRRKTLLALFTD-------HQWVAPAVATADLHSNFGSPTYFYAF-YHHCQTDQV 517

  Fly   435 PLNGENKPVGVGHADDLHYVLPGYWYGP--LMAANDS--DVFMMERLTSWFTHFAKTGTPLNSTD 495
            |...:     ..|.|::.|||.....||  |...|.|  ||.:...:.:::|:|||||.|.....
Human   518 PAWAD-----AAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVP 577

  Fly   496 ----------------IWPPCNSTVLKMLYNGVVTQVGSPGYSNRYAVWDKLFP 533
                            .|...:......|:.|:..:|.....:|:..:|.:|.|
Human   578 QDTKFIHTKPNRFEEVAWTRYSQKDQLYLHIGLKPRVKEHYRANKVNLWLELVP 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_609300.1	COesterase	27..528	CDD:395084	168/610 (28%)
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	168/609 (28%)