DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3841 and CES5A

DIOPT Version :9

Sequence 1:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001177087.1	Gene:	CES5A / 221223	HGNCID:	26459	Length:	604	Species:	Homo sapiens

Alignment Length:	569	Identity:	155/569 - (27%)
Similarity:	240/569 - (42%)	Gaps:	121/569 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 WALLLILIGFTTAVTFI-----------------GDDPVVELSLGRIQGDTMQSFGNKT-IYAFR 55
            |.|.|:...:..:.|..                 .:.|.....||.|||..:...|:.. :..|.
Human    23 WRLCLVYYFYPASSTLYVLRIDVLNYTSKDEGPSAEGPQRNTRLGWIQGKQVTVLGSPVPVNVFL 87

  Fly    56 GIRYAQSPVGQLRFANPVPETSWGDEVFNATSDSLVC------------------PQPGVVSLMS 102
            |:.:|..|:|.|||.||.|.:.| |.:..|||...:|                  |:.||    |
Human    88 GVPFAAPPLGSLRFTNPQPASPW-DNLREATSYPNLCLQNSEWLLLDQHMLKVHYPKFGV----S 147

  Fly   103 EDCLKINVFTKSFED---KFPVMVYIHGGANVLGSGHSSYEAGPQYLLDQDVVFVAFNYRLGALG 164
            ||||.:|::..:..|   |.||:|:..|||  ..:|.:|...|......:||:.|...||||..|
Human   148 EDCLYLNIYAPAHADTGSKLPVLVWFPGGA--FKTGSASIFDGSALAAYEDVLVVVVQYRLGIFG 210

  Fly   165 FLSTNSSETKGNFGFLDQVMALEWVRDHISHFGGDPELVTIIGISAGSMAVSLHLASPLSAGLFH 229
            |.:|......||:.|.|||.||.||:.:|..|||||..|||.|.|||:::||..:.||::.||||
Human   211 FFTTWDQHAPGNWAFKDQVAALSWVQKNIEFFGGDPSSVTIFGESAGAISVSSLILSPMAKGLFH 275

  Fly   230 RAILMSGSATNHF----DIDNLFWTRKLARELGCPMYDPTDVVECLRNETWTRIVEVCKAWETYQ 290
            :||:.||.|...:    |.:.....:.:|...|....|...::.|||.:....::.:.:..:::.
Human   276 KAIMESGVAIIPYLEAHDYEKSEDLQVVAHFCGNNASDSEALLRCLRTKPSKELLTLSQKTKSFT 340

  Fly   291 LVNMKWNYEIDGHFLHNHPTELIKEGNFNKVPLLISFTANEFDY----------------NANVH 339
            .|       :||.|..|.|.:|:.:..|..:|.:|....:|..:                :..:|
Human   341 RV-------VDGAFFPNEPLDLLSQKAFKAIPSIIGVNNHECGFLLPMKEAPEILSGSNKSLALH 398

  Fly   340 LENQHLLHDFASNFVDYAPELFL------YRHDAQIGEKLKDFYLGDNTTEINSENIENFGQIF- 397
            | .|::||         .|..:|      |.||..            :.|||....::..|.:|
Human   399 L-IQNILH---------IPPQYLHLVANEYFHDKH------------SLTEIRDSLLDLLGDVFF 441

  Fly   398 -SDAYIGHGVHRLVQLASHFTPVYYTRMDYVGDQSLSAPLNGENKP--VGVGHADDLHYVLPG-Y 458
             ..|.|....||     ....|||:....: ..|...     :.||  |...|||::.:|..| :
Human   442 VVPALITARYHR-----DAGAPVYFYEFRH-RPQCFE-----DTKPAFVKADHADEVRFVFGGAF 495

  Fly   459 WYGPLM---AANDSDVFMMERLTSWFTHFAKTGTPL-NSTDIWPPCNST 503
            ..|.::   .|.:.:..:..::..::..||:||.|. |...:||..|.|
Human   496 LKGDIVMFEGATEEEKLLSRKMMKYWATFARTGNPNGNDLSLWPAYNLT 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	151/534 (28%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	54/121 (45%)
CES5A	NP_001177087.1	COesterase	56..568	CDD:278561	151/536 (28%)
CES5A	NP_001177087.1	Aes	<155..>258	CDD:223730	43/104 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142598
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D233524at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750