DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3841 and Ces2e

DIOPT Version :9

Sequence 1:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001093947.1	Gene:	Ces2e / 192257	RGDID:	621563	Length:	557	Species:	Rattus norvegicus

Alignment Length:	573	Identity:	174/573 - (30%)
Similarity:	272/573 - (47%)	Gaps:	82/573 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LTWALLLILIGFTTAVTFIGDD---PVVELSLGRIQGDTMQSFGNKT-IYAFRGIRYAQSPVGQL 67
            :.|.|||:.....      |.|   |:.....|:::|..:.....|: ::.|.||.:|:.|:|.|
  Rat    13 VVWGLLLLFCQVQ------GQDSASPIRNTHTGQVRGSFVHVKDTKSGVHTFLGIPFAKPPIGPL 71

  Fly    68 RFANPVPETSWGDEVFNATSDSLVCPQ--PGV-------------VSLMSEDCLKINVFTKSFED 117
            |||.|.|...|.. |.:.||...:|.|  .|:             || ||||||.::::|.:...
  Rat    72 RFAPPEPPEPWSG-VRDGTSHPAMCLQNIDGLNLENLKIKMSRSPVS-MSEDCLYLSIYTPAHTH 134

  Fly   118 K---FPVMVYIHGGANVLGSGHSSYEAGPQYLLDQDVVFVAFNYRLGALGFLSTNSSETKGNFGF 179
            |   .||||:||||....|.. |:|: |......:|||.|...||||.|||.||.....:||:|:
  Rat   135 KDSNLPVMVWIHGGGLCWGMA-STYD-GSMLAAIEDVVVVTIQYRLGILGFFSTGDEHARGNWGY 197

  Fly   180 LDQVMALEWVRDHISHFGGDPELVTIIGISAGSMAVSLHLASPLSAGLFHRAILMSGSATNHFDI 244
            ||||.||.||:.:|.||||:|:.|||.|.|||.::||.|:.||:|.||||.||:.||.|.....|
  Rat   198 LDQVAALRWVQQNIVHFGGNPDRVTIFGESAGGISVSSHVVSPMSQGLFHGAIMESGVALLPNLI 262

  Fly   245 DN---LFWTRKLARELGCPMYDPTDVVECLRNETWTRIVEVCKAWETYQLVNMKWNYEIDGHFLH 306
            .|   :.:| .:|...||...|...::.|||.::...::.:.....|...|       :||.||.
  Rat   263 SNTSEVIYT-MVANLSGCEPVDSEALMSCLREKSEEEMLAINNIVRTISGV-------VDGKFLP 319

  Fly   307 NHPTELIKEGNFNKVPLLISFTANEFDY-------NANVHLENQHLLHDFASNFVDYAPELFLYR 364
            .||.||:...:|:.||.:|...::|:.:       ::.:...|:..:.....|   .|.::.|
  Rat   320 RHPLELLASVDFHPVPSIIGINSDEYGWIIPMLHPDSTMKEINRETMRAVLKN---TAVQMML-- 379

  Fly   365 HDAQIGEKLKDFYLGDNTTEINSENIE-NFGQIFSDAYIGHGVHRLVQLASHF----TPVYYTRM 424
             ..:..:.|.:.|:||  || :|:.:: .|.::..|...   |...:|:| ||    .|||:...
  Rat   380 -PPECSDLLMEEYMGD--TE-DSKTLQIQFNEMMGDFIF---VIPALQVA-HFQRSHAPVYFYEF 436

  Fly   425 DYVGD--QSLSAPLNGENKPVGVGHADDLHYVLPGYWYGPL-MAANDSDVFMMERLTSWFTHFAK 486
            .:..:  :.:..|      .|...|.|:|.||: ||.:..: ....:.:..:..::..::.:||:
  Rat   437 QHQSNFLKDIRPP------HVKADHGDELPYVI-GYLFWDMKFVFTEEEKLLSRKMIKYWANFAR 494

  Fly   487 TGTPLNSTDI--WPPCNSTVLKMLYNGVVTQVGSPGYSNRYAVWDKLFPTAAQ 537
            .|.| ||..:  ||..:... :.|...:...||....:.|...|.|..|...|
  Rat   495 HGNP-NSEGLPYWPALDHDE-QYLQLDIQPVVGRALKARRLKFWTKTLPQKIQ 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	165/542 (30%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	62/121 (51%)
Ces2e	NP_001093947.1	COesterase	30..536	CDD:278561	164/539 (30%)
Ces2e	NP_001093947.1	Aes	<127..>230	CDD:223730	50/104 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336300
Domainoid	1	1.000	232	1.000	Domainoid score	I2325
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3341
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D233524at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.800