DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3841 and cest-30

DIOPT Version :9

Sequence 1:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_504407.1	Gene:	cest-30 / 181871	WormBaseID:	WBGene00015071	Length:	578	Species:	Caenorhabditis elegans

Alignment Length:	590	Identity:	158/590 - (26%)
Similarity:	239/590 - (40%)	Gaps:	164/590 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLLILI--GFTTAVTFIGDDPVVELSLGRIQGDTMQ-SFGNKTIYAFRGIRYAQSPVGQLRFANP 72
            |||.::  ||...:|...:..::....|.|:|:..: ..|.|.:..:.||.:|::|||.|:|..|
Worm    12 LLLSIVEGGFLVNLTPEKNSQILNAPCGPIRGNIYKHKNGTKIVDGYLGIPFAKAPVGALKFKKP 76

  Fly    73 VPETSWGDEVFNATSDSLVCPQPG---------VVSLMSEDCLKINVFT-----KSFEDKFPVMV 123
            |....| .|..:.......|||.|         ..:...|:||.:|||.     ..|....||:|
Worm    77 VAAEKW-TEPRDCYEYGPGCPQTGRFAALTAKSTAAFAEENCLTLNVFAPRWKLAEFPKGLPVLV 140

  Fly   124 YIHGGANVLGSGHSSYEAG-PQYLLD---------QDVVFVAFNYRLGALGFLSTNSSETKGNFG 178
            ||:||         .||.| ..|:.|         :||:.|..|||||.||||:.......||:|
Worm   141 YIYGG---------GYEIGFTSYMDDYSLTGTLPLKDVIVVTMNYRLGPLGFLTIADGIANGNYG 196

  Fly   179 FLDQVMALEWVRDHISHFGGDPELVTIIGISAGSMAVSLHLASPLSAGLFHRAILMSGSATNHFD 243
            ..||.:||:||:|:|:.|||:||.||:.|.|||:.:......||.|..||.|:|.|||:|..:|.
Worm   197 LWDQTLALQWVQDNIASFGGNPESVTLSGTSAGATSTDFLSLSPHSNQLFQRSISMSGTAFCNFA 261

  Fly   244 IDNLFWTRKLARELGCPMYDPTDVVECLRNETWTRIVEVCK---------------AWETYQLVN 293
            |                  .|.||.           |.|||               .::.|...|
Worm   262 I------------------RPKDVE-----------VGVCKEFAQFQGYTGTDSQSLFDWYMAQN 297

  Fly   294 MKWNYEIDGH---------FLHN-------HPTELIKEGNFNKVPLLISFTANEFD---YN---A 336
            :....|:.|.         |:.|       .|.::::.....|..|:...|.....   :|   |
Worm   298 VSKFKEVAGFQSTAAGAVPFIPNFDGDFFPKPFDILRREAPKKDALITVVTMESVGMIIFNPLFA 362

  Fly   337 NVHLENQHLLHDFASNFVDYAPELFLYRHDAQIGEKLKDFYLGD-NTTE---IN-------SENI 390
            |.:...:..:::      .|.|::..|.  |.:.:||..|||.| |.::   :|       |:::
Worm   363 NAYNNFEGFINE------TYGPDVTDYY--ADVKKKLTGFYLKDVNASDKATVNRRVVDYVSDSV 419

  Fly   391 ENFGQIFSDA---YIGHGVHRLVQLASHFTPVYYTRMDYVGDQS-----LSAPLNGENKPVGVGH 447
            .|.|.:  ||   |:.:|           ..||....:|..|.:     |..|..      ...|
Worm   420 FNSGTL--DAVKSYVKYG-----------NKVYLGSFNYFNDATKDMVELMQPFK------EASH 465

  Fly   448 ADDLHYVLPGYWYGPLMAAN----DSDVFMMERLTSWFTHFAKTGTP--LNSTDIWPPCNSTVLK 506
            :.|..     |::|..:.||    |.::.:|:...:...:|.|.|.|  .:.|..|.|  .|:||
Worm   466 SSDFK-----YYFGSGVMANFTPTDEEMEVMDMSGTLMANFVKYGDPNGKSGTKPWKP--YTILK 523

  Fly   507 --MLY 509
              |.|
Worm   524 PNMYY 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	152/572 (27%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	53/128 (41%)
cest-30	NP_504407.1	COesterase	31..539	CDD:278561	152/571 (27%)
cest-30	NP_504407.1	Aes	<122..>230	CDD:223730	48/116 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157265
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.740