DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3841 and cest-13

DIOPT Version :9

Sequence 1:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_741921.1	Gene:	cest-13 / 181493	WormBaseID:	WBGene00010116	Length:	548	Species:	Caenorhabditis elegans

Alignment Length:	543	Identity:	152/543 - (27%)
Similarity:	229/543 - (42%)	Gaps:	88/543 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LILIGFTTAVTFIGDDPVVELSLGRIQGD-TMQSFGNKTIYAFRGIRYAQSPVGQLRFA-----N 71
            |:|:.|.:.:.    ||..::::....|. |::...:....:||||||||.|||..||.     :
Worm     9 LLLLHFASVLA----DPTYDVTVQTPNGSATIRGIQHTYGTSFRGIRYAQPPVGLFRFGAARRLD 69

  Fly    72 PVPETSWGDEVFNATSDSLVCPQPGVVSLMSEDCLKINVFTK---SFEDKFPVMVYIHGGANVLG 133
            ||       .:..|.:...:|.| |......||||.|||:|.   :...|.||.||||||..|.|
Worm    70 PV-------GLVEAQAYGNICVQ-GDGRTSHEDCLFINVYTPNNVTQASKLPVYVYIHGGGFVEG 126

  Fly   134 SGHSSYEAGPQYLLDQDVVFVAFNYRLGALGFLSTNSSETKGNFGFLDQVMALEWVRDHISHFGG 198
            .|:......|..:....:|.|:.|||||..||.||......||:...|.:.||.||:.:||.|||
Worm   127 GGNMGAGIYPNLVNKGPIVMVSINYRLGPFGFFSTRQMTAPGNWAISDWIEALNWVQRYISFFGG 191

  Fly   199 DPELVTIIGISAGSMAVSLHLASPLSAGLFHRAILMSGSATNHFDIDNLFWTRK-------LARE 256
            ||..|||.|.|:|:.|||....:||:..||.::|..||||   |....:.::.|       |:.:
Worm   192 DPNRVTIGGQSSGAEAVSTLTLTPLAKNLFKQSIHESGSA---FGAAVMSYSEKTRSTSKQLSIK 253

  Fly   257 LGCPMYDPTD-------VVECLRNETWTRIVEVCKAWETYQLVNMKWNYEIDGHFLHNHPTELIK 314
            |||...|..|       ::.||||.|:.:||....:...::   |||:...|..:|......|..
Worm   254 LGCATSDQWDNGQSFGTILTCLRNVTYDKIVAADNSLPGHR---MKWSIVQDNKYLTQRLEYLAL 315

  Fly   315 EGNFNKVPLL-------ISFTANEFDYNANVHLENQHLLHD-----FASNFVDYAPELFLYRHDA 367
            :.:..|..|:       :.:..|...:|.|......|.:.|     :...:.|....:.:...:.
Worm   316 QRDPKKNVLIGDVHDEWLGWEMNNVLHNINSSHNTAHQMRDDLSGSYEMTYWDNKQSVLVAADNK 380

  Fly   368 QIGEKLKDFYLGDNTTEINSENIENFGQIFSD-AYIGHGVHRLVQLASHFTPVYYTRMDYVGDQS 431
            .|..:   .:..||..|..:..|    |::|: .:||..:............||...:|::...:
Worm   381 YINNQ---GWTDDNHREWEARRI----QLWSEMVFIGPTLRDAAYFQYMKNNVYLYSLDWLSPPA 438

  Fly   432 LSAPLNGENKPVGVGHADDLHYVLPGYWYGPLMAANDSDVFMMERLTSWFTHFAKTGTPLNSTDI 496
            |  ||..:....|..|..:|.|:......|....|.|      |.|.::||
Worm   439 L--PLVTDPLFRGCEHTWELQYIFSTSCNGFTCTAQD------EILRNYFT-------------- 481

  Fly   497 WPPCNSTVLKMLYNGVVTQVGSP 519
                 :|.|..:..|..|..|||
Worm   482 -----TTWLNFIIGGNPTPAGSP 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	149/529 (28%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	52/118 (44%)
cest-13	NP_741921.1	Abhydrolase	22..510	CDD:304388	147/526 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910