DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3841 and cest-2.3

DIOPT Version :9

Sequence 1:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_506510.2	Gene:	cest-2.3 / 179918	WormBaseID:	WBGene00013873	Length:	665	Species:	Caenorhabditis elegans

Alignment Length:	523	Identity:	137/523 - (26%)
Similarity:	224/523 - (42%)	Gaps:	99/523 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 QLTWALLLILIGFTTAVTFIGDDPVVELSLGRIQGD----TMQSFGNKTIYAFRGIRYAQSPVGQ 66
            |..:..:||.:..:|.         ::||.|.|:|.    |...|||:|...|.||.|.:.|:|:
Worm     4 QYLYFAVLIHLSISTR---------IQLSTGTIEGKILNATYSPFGNQTATVFLGIPYVEPPIGE 59

  Fly    67 LRFANPVPETSWGDEVFNATSDSLVCP-------QPGVVSLMSEDCLKINVFTKSF---EDKFPV 121
            |||..|....|| :.|.........|.       :.|.|..:|||||..||||..:   .....|
Worm    60 LRFRKPRLLKSW-EGVLETKDYKPACMSYWRKTFKNGFVGEISEDCLYANVFTNQYCLQNKNCSV 123

  Fly   122 MVYIHGGANVLGSGHSSYEAGPQYLL------DQDVVFVAFNYRLGALGFLSTNSSETKGNFGFL 180
            |:.:|||..|..|| |:::  |:..:      |:::|.|.||||||..||...|......|....
Worm   124 MIVVHGGRLVCESG-SAFK--PEIFINNFVGQDRNIVVVTFNYRLGVFGFGVFNGETGDTNVAMY 185

  Fly   181 DQVMALEWVRDHISHFGGDPELVTIIGISAGSMAVSLHLASPLSAGLFHRAILMSGSATNHFDID 245
            |.:.|::|||..|..|||:.:.:|:.|.|||:..:....:|.||.||.|:.|:||....:.....
Worm   186 DMLEAVKWVRKEIDQFGGNKDRITMAGHSAGAGLIVDFTSSTLSKGLLHQQIVMSAPLQDISKSA 250

  Fly   246 NLFWTRKLARELGC-------PMYDPTDVVE---CLRNETWTRIVEVCKAWETYQLVNMKWNY-- 298
            |......:|:.:||       .....|.:.:   ||:|::...::        :..::|:.|.
Worm   251 NFKGMTIVAQNVGCIPKEYGFRKLSKTQINKTYLCLQNKSAQDLL--------HAQLSMQQNSTF 307

  Fly   299 -----EIDGHFLHNHPTELIKEGNFNKV-PL--LISFTANEFDYNANVHL---ENQHLLHDFASN 352
                 .:||.|:.::|..|.   |||.: |:  .|..|..|.  ..::::   :|..:......|
Worm   308 YFGSPRVDGDFITDYPDNLF---NFNTIYPINTFIGTTTGEL--RDSLYITDPKNDRIKEQLLKN 367

  Fly   353 FVDYAP-ELFLYRHDAQIGEKLKDFYLGDNTTEINSENIENFGQIFSDAYIGHGVHRLVQLASHF 416
            ..::.. |||  ....:..:|..::|......:..|:::|    .:|.|......|:...
Worm   368 MCEHVGYELF--EKPEEFTKKCGNYYKNGTDAQFLSDDME----FYSGAIKVANAHKRAN----- 421

  Fly   417 TPVYYTRMDYVG-----DQSLSAPLNGENKPVGVGHADDLHYVLPGYWYGPLMAANDSDVFMMER 476
            :.|:....||.|     .:.|.||        ...|::||.|.. |...||.:|.:    :::||
Worm   422 SKVFMYSYDYKGAGTAFHKYLEAP--------SPHHSEDLIYTF-GTSRGPFVAKD----YVIER 473

  Fly   477 LTS 479
            :.|
Worm   474 IYS 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	133/502 (26%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	44/124 (35%)
cest-2.3	NP_506510.2	Abhydrolase	20..532	CDD:389770	133/498 (27%)
cest-2.3	NP_506510.2	CemA	<550..>647	CDD:383495
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157034
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740