DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3841 and cest-1.1

DIOPT Version :9

Sequence 1:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_506506.1	Gene:	cest-1.1 / 179915	WormBaseID:	WBGene00011362	Length:	673	Species:	Caenorhabditis elegans

Alignment Length:	587	Identity:	153/587 - (26%)
Similarity:	245/587 - (41%)	Gaps:	98/587 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VELSLGRIQGDTM----QSFGNKTIYAFRGIRYAQSPVGQLRFANPVPETSWGDEVFNATSDSLV 91
            |:||.|.|:|..:    ...||::...|.||.:.:.|:|.||:..|.|..|| :.|.........
Worm    19 VQLSSGTIEGKILNISYSPLGNQSATVFLGIPFVEPPIGDLRYRKPRPPKSW-EGVLVTNEYKSA 82

  Fly    92 CPQPGVVSL-------MSEDCLKINVFTKSF--EDK-FPVMVYIHGGANVLGSGHSSYEAGPQYL 146
            |......:.       :|||||.:||.|..:  |:| ..||:.:|||..:..|. |::  .|:.|
Worm    83 CMSNATKTYKNKFGGPISEDCLYLNVLTNEYCLENKNCSVMMIVHGGGYLTESA-STF--NPEIL 144

  Fly   147 LD------QDVVFVAFNYRLGALGFLSTNSSETKGNFGFLDQVMALEWVRDHISHFGGDPELVTI 205
            ::      :::|.|.||||||...|...|......|||..|.:.::.|||..|.:|||:...:|:
Worm   145 INNFVGQGRNIVVVTFNYRLGLFSFGQFNGDRGDKNFGLYDMIESVNWVRREIENFGGNKNRITL 209

  Fly   206 IGISAGSMAVSLHLASPLSAGLFHRAILMSGSATNHFDIDNLFWTRKLARELGCPMYD------P 264
            .|.|||:..:....:|||:.||.|:.|:||...||.....|......:|:.:||...:      .
Worm   210 AGHSAGASMIVAFTSSPLTKGLVHQQIIMSAPMTNMSKKSNFKGMTVMAQMVGCLSEEIGFNKLS 274

  Fly   265 TDVVE----CLRNETWTRIVEVCKAW----ETYQLVNMKWNYEIDGHFLHNHPTELIKEGNFNKV 321
            .:.||    |||.::..:|:: .:.|    .||.|    ....||.|||.::|..|....:...:
Worm   275 EEQVENTYSCLRKKSAQQILD-AQLWLLQNSTYFL----GAPPIDEHFLTDYPENLYASKSIYPI 334

  Fly   322 PLLISFTANEFDYNANVHLENQHLLHD-FASNFVDYAPEL------FLYRHDAQIGEKLKDFYLG 379
            ..||..|..|.:       |:.:::.. ||...|:....|      .||.......:|.:..|:.
Worm   335 NTLIGTTTLEVE-------ESSYIIDPAFADKKVELLENLCDHIGYVLYEEPETFSKKCQKQYMN 392

  Fly   380 DNTTEINSENIENFGQIFSDAYIGHGVHRLVQLASHFTPVYYTRMDYVG-----DQSLSAPLNGE 439
            .|    :|.|:.|..:.::.|......|     .|..|.|:....||.|     |:.|..
Worm   393 GN----SSMNLSNEMEFYTPAIDFADSH-----TSGNTKVFLYSYDYRGAGPAYDRYLEV----- 443

  Fly   440 NKPVGVGHADDLHYVLPGYWYGPLMAANDSDVFMMERLTS-WFTHFAKTGTPLNSTD-IWPPCNS 502
            ..|   .|::||.||. |...| :.|..|   :::|::.| .|..|.....||.|.| .|.....
Worm   444 RSP---HHSEDLIYVF-GTHRG-IFAPKD---YIIEKIYSGMFADFVNFENPLPSGDQKWNQYTK 500

  Fly   503 T-----VLKMLYNGVVTQVGSPGYSNRYAVWDKLFPTAAQGGGAALKLSFAVAIATGVASRLIGK 562
            .     ::....|.:...:....|:..|..|..:       |..:.|..::.::.|...:.:|..
Worm   501 ENREHFLINFDKNFITPGMRDNYYTEAYEFWSTV-------GKKSFKEEWSPSLDTFTCALVISP 558

  Fly   563 LM 564
            |:
Worm   559 LV 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	147/549 (27%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	44/125 (35%)
cest-1.1	NP_506506.1	COesterase	19..531	CDD:278561	147/549 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157085
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740