DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3841 and cest-34

DIOPT Version :9

Sequence 1:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001360105.1	Gene:	cest-34 / 179057	WormBaseID:	WBGene00019652	Length:	550	Species:	Caenorhabditis elegans

Alignment Length:	526	Identity:	154/526 - (29%)
Similarity:	233/526 - (44%)	Gaps:	90/526 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VTFIGDDP---VVELSLGRIQGDTMQSFGNKTIYAFRGIRYAQSPVGQLRFANPVPETSWGDEVF 83
            ::::..:|   |:..|.|.:.|: :...|:|.::.:.|:.||:.|.|::|||.|||...| .|..
Worm     5 LSYLKPEPLGTVLNTSCGPVLGN-LYRHGDKEVHGYLGMPYAKPPTGEMRFAKPVPADDW-TETR 67

  Fly    84 NATSDSLVCPQPG-------VVSLMSED---CLKINVF-----TKSFEDKFPVMVYIHGGANVLG 133
            :.|.....||..|       .|:....|   .|.:|||     :..:::..|||||:|||...:.
Worm    68 DCTKYGPRCPPSGQGLEKGMFVNPDEPDEANGLSVNVFVPGWESSEYKNARPVMVYVHGGGFEIS 132

  Fly   134 SGHSSYEAGPQYLLD-QDVVFVAFNYRLGALGFLSTNSSETKGNFGFLDQVMALEWVRDHISHFG 197
            |.....:......|. :||:.|..|||||.|||.:|......||||..||.:||:||:.||:.||
Worm   133 SSREFCDYSISSTLPMKDVILVTMNYRLGILGFFTTGDEVCPGNFGLWDQTLALQWVQKHIASFG 197

  Fly   198 GDPELVTIIGISAGSMAVSLHLASPLSAGLFHRAILMSGSATNHFDI----------DNLFWTRK 252
            |||..||:.|.|||...|.|...||.|..||.:.:.|||||...|.:          |::
Worm   198 GDPNNVTLFGQSAGGACVDLLTLSPHSRDLFQKVVPMSGSAMCEFAMRTAENEAHVFDDI----- 257

  Fly   253 LARELGCPMYDPTDVVECLRNETWTRIVEVCKAWETYQ---LVNMKWNYEIDGHFLHNHPTELIK 314
            ||| ||.......:.:|.:|:....:|..  |...||:   .:::..||  ||.|......||.|
Worm   258 LAR-LGFTGSGSKERLEFMRSLPCDKITG--KTGYTYKQSGFMSLCPNY--DGDFFPKPLDELRK 317

  Fly   315 EGNFNKVPLLISFTANE-----FDYNANVHLENQHLLHDFASNFVDYAPELFL-----YRHDA-- 367
            :.  :|..|:.....||     ||.|               :.:.||...|.|     |:.|.
Worm   318 DA--SKRILMTGIVGNEGLLFAFDRN---------------TPYKDYTDLLRLKIEEDYKEDVVD 365

  Fly   368 ---QIGEKLKDFYLGDNTTEINSENI-ENFGQIFSDAYIGHGVHRLVQ-LASHFTPVYYTRMDYV 427
               .|.:::.::|. .|.:|.:.|.| ....:...|:....||....| .|.|...|:....||.
Worm   366 DVEGIRKEIFEYYT-KNISEGDEEAIMRKAAEFVGDSIFHTGVRATAQNAAEHGDEVWLYNFDYC 429

  Fly   428 GDQSLSAPLNGENKPVGVGHADDLHYVLPGYWYGPLMAA----NDSDVFMMERLTSWFTHFAKTG 488
            ..... |||.|....:...|..:|.|:     :|..:.:    .:.::.|:::.|:.|.:|||.|
Worm   430 NPDGF-APLKGYLPYIEPTHGMELRYL-----FGDGIISKFEPTEEELKMLDKFTTMFANFAKYG 488

  Fly   489 TPLNST 494
            .| |.|
Worm   489 NP-NET 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	154/521 (30%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	52/119 (44%)
cest-34	NP_001360105.1	COesterase	15..530	CDD:365897	153/516 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D233524at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820