DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3841 and cest-5.1

DIOPT Version :9

Sequence 1:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_501022.3	Gene:	cest-5.1 / 177429	WormBaseID:	WBGene00015279	Length:	580	Species:	Caenorhabditis elegans

Alignment Length:	536	Identity:	126/536 - (23%)
Similarity:	212/536 - (39%)	Gaps:	144/536 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLILIGFTTAVTFIGDDPVVELSLGRIQGDTMQSFGNKTIYAFRGIRYAQSPVGQLRFANPVPET 76
            ||:||....|    .|..::..|.|.::|..:..:     :.|:.|.:|:.|||.|||..|....
Worm     6 LLLLIFIINA----ADSLIIHTSFGHLEGAEIGDY-----HLFKKIPFAKPPVGNLRFQKPEAAG 61

  Fly    77 SWGDEVFNATSDSLVC---------PQPGVVSLMSEDCLKINVFT--KSFEDK-FPVMVYIHGGA 129
            .| |.:.:|......|         ||..|    .||||.:|:||  |..:.: ..:.||||||.
Worm    62 KW-DGIRSAIEYGPACMSNSSKTKSPQKWV----DEDCLHVNIFTSKKCLKSRNCAIAVYIHGGG 121

  Fly   130 NVLGSGHSSYEAGPQY----LLD----QDVVFVAFNYRLGALG-FLSTNSSETKGNFGFLDQVMA 185
                   .:|::...:    |||    :||:.|...:|||... |...|.:....|....|..:|
Worm   122 -------LTYDSAVMFNDTVLLDTFVKRDVILVIPGFRLGIFSHFTVHNQNVAPNNLALYDITLA 179

  Fly   186 LEWVRDHISHFGGDPELVTIIGIS-AGSMAVSLHLASPLS--AGLFHRAILMSGSATNHFD--ID 245
            ||:|:..|..|||:.:.:|:.|.| .|.:|..:..:|.::  ..||.:||:|||..  :|:  .|
Worm   180 LEFVKSEIHSFGGNSQKITLFGHSYGGGLASMMTFSSEINRDLSLFQQAIVMSGGF--YFEELKD 242

  Fly   246 NLFWTRKLARELGC---------------PMYDPTDVVECLRNETWTRIVEVCKAWETYQLVNMK 295
            ::..|::......|               .||    :::||:..:...::.:.:..|..
Worm   243 HIEGTKRFVEYANCSVPLKLERKMERSQQEMY----MMKCLQKLSGMELLRIQRLLEDK------ 297

  Fly   296 WNYEIDGHFLHNHPT-------ELIKEGNFNKVPLLISFTANEFDYNA-----NVHLENQHLLHD 348
             .|...|..:...|.       ||:|..  ..:|:|...|..|||:.:     ..:||.::
Worm   298 -GYPDFGGVILREPLFPDVKKFELLKSP--KNIPMLTGCTNLEFDHESIKVPFGKYLEFEN---- 355

  Fly   349 FASNFVDYAPELFLYRHDAQIGEKLKDFYLGDNTTEINSENIENFGQIFSDAYIGHGVHRLVQ-- 411
                 .|...|  .||:|.:.|                   :||.|. .:|...|..:...:|
Worm   356 -----PDECDE--KYRNDVESG-------------------VENRGN-HTDKTQGIILPLKLQIN 393

  Fly   412 --LASHFTPVYYTRMDYVGDQSLSAPLNGENKPVGVGHADDLHYVLPGYWYGPLMAANDSDVFMM 474
              |.::.|...|   :|      :.|.:|.       |.|||.|::..:.:    ..::::|.:.
Worm   394 NLLENNVTAYLY---EY------TYPKHGR-------HTDDLSYIMGVHAF----EKDENEVHLE 438

  Fly   475 ERLTSWFTHFAKTGTP 490
            :.......:|.|.|.|
Worm   439 QVYKDMVINFIKLGEP 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	121/521 (23%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	38/131 (29%)
cest-5.1	NP_501022.3	Abhydrolase	19..495	CDD:389770	120/519 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156904
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740