DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3841 and cest-12

DIOPT Version :9

Sequence 1:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_499576.4	Gene:	cest-12 / 176642	WormBaseID:	WBGene00013540	Length:	850	Species:	Caenorhabditis elegans

Alignment Length:	524	Identity:	129/524 - (24%)
Similarity:	204/524 - (38%)	Gaps:	128/524 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VELSLGRIQGDTMQSFGN--KTIY-----AFRGIRYAQSPVGQLRFANPVPETSWGDEVFNATSD 88
            |..|.|.:||..: :.||  ..:|     ||.||.|.|:|||.||...|.|...:...:.:||..
Worm    37 VSCSQGSVQGRQV-NLGNDQSQLYSGQANAFTGIPYCQAPVGNLRLQPPQPLNQFNTTLHDATYF 100

  Fly    89 SLVCPQPGVVSLMSEDCLKINVFTK---SFEDKFPVMVYIHGGANVLGSG-HSSYEAG-PQYLLD 148
            ...|||.......:||||.:||:|.   :......|:|.|.|.......| ..:.|.| ...|:.
Worm   101 RPKCPQLNAGGPTNEDCLYLNVYTPQAGNTNANLSVLVLIDGSNGFSNGGCDQNQEKGIISNLVQ 165

  Fly   149 QDVVFVAFNYRLGALGFLSTNSSETKGNFGFLDQVMALEWVRDHISHFGGDPELVTIIGISAGSM 213
            :.:|.|...||:|||||.:|.::..:.|.|.||||.|:.|::..|.:|||:|..:|:.|...|:.
Worm   166 RQIVVVTMQYRIGALGFFTTYTNSVQSNLGMLDQVQAMRWIKTEIVNFGGNPNQITVAGQDDGAC 230

  Fly   214 AVSLHLASPLSAGLFHRAILMSGSATNHFDIDNLFWTR-KLARELGCPMYDPTD----------- 266
            |||.|..||:|..||::||:.|||..:.::......|. ::......||||.::
Worm   231 AVSAHCLSPMSQNLFNQAIVQSGSVYSCYNPTPAVPTNPQVQVTTPRPMYDQSNTGYGNAGYQNN 295

  Fly   267 ---------------------------VVECLRN---ETWTRIVEVCKAWETYQLVNMKWNYEID 301
                                       :.:.|.|   :.|..       .:|..:.|...||.:|
Worm   296 YGYQPQPITSTSSYNSANAQYDDPSQQLAQTLCNISPDQWNN-------GQTQNIQNCMKNYTVD 353

  Fly   302 GHFLHNHP------TELIKEGNF------------NKVPLLISFTANEFDYNANVHLEN------ 342
             .|::..|      ..::::.:|            ..:|::|. |..:.|.:....|.|
Worm   354 -FFVNQQPGGPNATWMIVRDTSFLPGSIDSLTTRRPNIPIIIG-TVQDEDADYAFKLINTGKGSD 416

  Fly   343 QHLLHDFASNFVDYAPELFLYRHDA-QIGEKLKDFY------LGDNTTEINSENIENFGQIFSDA 400
            .:.|.|:   ..|:|.:..|.:..| |:...:.:.|      ||....::||:
Worm   417 PNNLDDW---IFDFARKNKLNQTQANQVSNIISNNYGVNTGALGQQGAQVNSQ------------ 466

  Fly   401 YIGHGVHRLVQLASHFTPVYYTRMDYVGDQSLSAPLNGENKPVGVGHADDLHYVLPGYWYGPLMA 465
            |.|.|..:.|......|....|...|..||......|                  .|.:||.::|
Worm   467 YQGSGTGQQVNNQYQNTQGQQTNNQYQYDQGGQQTNN------------------QGAYYGGVVA 513

  Fly   466 ANDS 469
            ...:
Worm   514 GQQT 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	129/524 (25%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	45/120 (38%)
cest-12	NP_499576.4	Abhydrolase	37..>400	CDD:389770	100/372 (27%)
cest-12	NP_499576.4	Abhydrolase	<678..774	CDD:389770
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810