DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3841 and cest-25

DIOPT Version :9

Sequence 1:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_497609.1	Gene:	cest-25 / 175390	WormBaseID:	WBGene00022178	Length:	550	Species:	Caenorhabditis elegans

Alignment Length:	502	Identity:	154/502 - (30%)
Similarity:	220/502 - (43%)	Gaps:	52/502 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SLGRIQGDTMQSFGNKTIYAFRGIRYAQSPVGQLRFANPVPETSWGD----EVFNA---TSDSLV 91
            |.|.|:|..:...|.|.:.||:||.||..|:|.||||.|.|...|.:    :.|.|   ..|.::
Worm    22 SYGPIEGRRLIHEGEKQVDAFQGIPYAAPPIGNLRFALPQPHEKWTEVRETKSFGARGIQKDHVL 86

  Fly    92 CPQPGVVSLMSEDCLKINVFTKSFEDK----FPVMVYIHGGANVLGSGHSSYEAG-PQYLLDQDV 151
            .|:   .|..|||.|.:|:||..:..|    |||::|||||..|..|.|...:.. .|:|:.:||
Worm    87 SPK---TSPQSEDNLTLNIFTPVWTPKNETGFPVILYIHGGGFVSDSAHKYGDMSICQHLVTKDV 148

  Fly   152 VFVAFNYRLGALGFLSTNSSETKGNFGFLDQVMALEWVRDHISHFGGDPELVTIIGISAGSMAVS 216
            |.|...||||.|||.:|..|....|....|.|.||:||:::|..|.|||..:|::|.|||..:|.
Worm   149 VVVTIQYRLGFLGFWTTGDSSIPDNVALHDMVFALKWVKENIGLFNGDPNNITLMGQSAGGASVD 213

  Fly   217 LHLASPLSAGLFHRAILMSGSATNHFDID--NLFWTRKLARELGCPMYD---PTDVVECLRNETW 276
            ....||:|..||.:.|.|.|:|:..:.|.  .|...|..|:|:|  ::|   ..|.||.||....
Worm   214 FLSISPVSRDLFQKVIPMGGNASCSWAIHPRPLNACRNRAQEIG--VFDGMNTLDWVEKLRELPA 276

  Fly   277 TRIVEVCKAWETYQLVNMKWNYEI------DGHFLHNHPTELIKEGNFNKVPLLISFTANEFDYN 335
            .:.....    ..:.|:.|.:.|:      |..|:.....||.||....  |.|:....:|....
Worm   277 DKFASAL----NMEAVDTKTDPELLIGPKYDNLFIPRPVMELRKEAPMK--PRLLGCAKSEGLVF 335

  Fly   336 ANVHLENQHLLHDFASNFVDYAPE-LF-LYRHDAQIGEKLKDFYLGDNTTEINSENIENFGQIFS 398
            |...|..:|.||....:......| || |...|.|  ||..:..:...|.....|.......:..
Worm   336 AFFGLNTKHPLHAVQQDVSAILSEKLFPLKARDYQ--EKALEKLIEIGTDHSKEEWQRAMVDLKG 398

  Fly   399 DAYIGHGVHRL---VQLASHFTPVYYTRMDYVGDQSLSAPLNGENKPV-GVGHADDLHYVLPGYW 459
            |:::..|:.:.   |......||:|....||...::..  :.|...|. ...|..|:.||:..:.
Worm   399 DSFLNVGIQQNVLDVLETQPSTPIYMYSFDYCNPKAYG--IMGFKLPFKDATHCTDISYVVGNHI 461

  Fly   460 YGPLMAANDSDVFMMERLTSWFTHFAKTGTPLNSTD-------IWPP 499
            ... ...|:.|..|:|..|..:|:|||.|.|....|       .|.|
Worm   462 VNS-FDFNEEDYKMIEITTRLWTNFAKYGNPNGEGDDVAHLEEKWEP 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	154/502 (31%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	51/123 (41%)
cest-25	NP_497609.1	COesterase	18..536	CDD:365897	154/502 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810