DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3841 and cest-27

DIOPT Version :9

Sequence 1:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_871861.2	Gene:	cest-27 / 171610	WormBaseID:	WBGene00018958	Length:	561	Species:	Caenorhabditis elegans

Alignment Length:	562	Identity:	161/562 - (28%)
Similarity:	234/562 - (41%)	Gaps:	97/562 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 VVELSLGRIQGDTMQSFGNKTIYAFRGIRYAQSPVGQLRFANPVPETSWGDEV----FNATS--- 87
            |.:.:.|.|:|...:......:..|.||.||:.|:|.|||..||....|.:.:    |...|
Worm    27 VHDATCGPIKGVGYEQEDGSVVEGFLGIPYAEPPIGALRFKKPVAHRKWTEPLDCVRFGPRSPQN 91

  Fly    88 DSLVCPQPGVVSLMSEDCLKINVFTKSFE-----DKFPVMVYIHGGANVLGSGHSSYEAG----P 143
            |.|:......|....|.||.:||||..:|     |.|||||:||||...:   |||...|    .
Worm    92 DELLGQFVNTVGKSEEHCLSLNVFTPKWESNEWPDGFPVMVFIHGGGFAV---HSSSNYGCASIA 153

  Fly   144 QYLLDQDVVFVAFNYRLGALGFLSTNSSETKGNFGFLDQVMALEWVRDHISHFGGDPELVTIIGI 208
            :.|..:|||.|..|||||.|||.:|.....:||.|..||..|||||:::|..|.|||:.|||.|.
Worm   154 RNLCTKDVVVVTINYRLGVLGFFTTGDEVCRGNLGLWDQTAALEWVQENIQSFRGDPDNVTIFGQ 218

  Fly   209 SAGSMAVSLHLASPLSAGLFHRAILMSGSATNHFDI----DNLFWTRKLARELGC--PMYDPTDV 267
            |||..:|.|...||.|.|||:|||.|:|:....|.:    .....:|:.||.||.  ...|..|:
Worm   219 SAGGASVDLLCLSPHSRGLFNRAIPMAGNGECDFAMRTSEQQAQLSREFARYLGWEGDDNDSEDL 283

  Fly   268 VECLRNETWTRI---VEVCKAWETYQLVNMKWNYEIDGHFLHNHPTELIKEGNFNKVPLLISFTA 329
            ::.:..:...:|   :...:.::..|..::.:....||.|......:|.||.  .|:.::...|.
Worm   284 LQFIDQQPLYKIEMGINPKRGFKHSQAGSLYFVPNFDGDFFPKPLNQLRKEA--PKMQIMTGTTK 346

  Fly   330 NE--FDYNANVHLENQHLLHDFASNF---VDYAPELFLYRHDAQIGEKLKDFYLGDNTTEINSEN 389
            .|  |........:|...:..|....   .||..     |.| .:.:.:.|||......:.:.:|
Worm   347 YEGLFFIALGALSKNPEGIKKFMGRIFKECDYGE-----RAD-DVLQMVYDFYFKGVHPKDHEKN 405

  Fly   390 IENFGQIFSDAYIGHGVHRLVQLASHFT-PVYYTRMDYVGDQSLSA-----PLNGENKPVGVGHA 448
            :....:...|..|.:|.:||..:.:... .||:.:.||........     |.      :|..|.
Worm   406 MHQIVKFIGDYSINYGTYRLANIMTDLQHDVYFYQFDYHNSAGFGVFRWLLPF------LGSTHC 464

  Fly   449 DDLHYVLPGYWYGPLMAANDSDVFMMERLTSWFTHFAKTGTPLNSTDIWPPCNSTVLKMLYNGVV 513
            .::.||| |.........||:|..|:..:|::||:|||.|.|                   ||..
Worm   465 TEMRYVL-GKGIISKFRPNDNDKKMLHVMTTYFTNFAKYGNP-------------------NGEN 509

  Fly   514 TQVGS-----------------------PGYSNRYA-VWDKL 531
            .:.|.                       ..|..|.| :||||
Worm   510 QETGEWQKHDSAHPFRHFKIDLDDSEMVEDYQERRAELWDKL 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	157/557 (28%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	62/127 (49%)
cest-27	NP_871861.2	COesterase	29..541	CDD:278561	153/548 (28%)
cest-27	NP_871861.2	Aes	<114..>283	CDD:223730	74/171 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157299
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840