Protein Alignment CG3841 and AADAC

DIOPT Version :10

• Sequence 1: NP_609300.1
• Gene: CG3841 / 34278
• FlyBaseID: FBgn0032131
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001077.2
• Gene: AADAC / 13
• HGNCID: 17
• Length: 399
• Species: Homo sapiens
• Alignment Length: 282
• Identity: 60/282 - (21%)
• Similarity: 103/282 - (36%)
• Gaps: 101/282 - (35%)

  Fly   122 MVYIHGGANVLGSGH-SSYEAGPQYLLDQ-DVVFVAFNYRLGALGFLSTNSSETKGNF--GFLDQ 182
            :.|||||...:||.. |.|:...::..|: |.|.|:.||||.           .|.:|  .|.|.
Human   107 LFYIHGGGWCVGSAALSGYDLLSRWTADRLDAVVVSTNYRLA-----------PKYHFPIQFEDV 160

  Fly   183 VMALEWV--RDHISHFGGDPELVTIIGISAGSMAVSLHLASPLSAGLFHRAILMSGSATNHFDID 245
            ..||.|.  :..::.:|.:||.:.|.|.|||.     :||:.::     :.:|..........|.
Human   161 YNALRWFLRKKVLAKYGVNPERIGISGDSAGG-----NLAAAVT-----QQLLDDPDVKIKLKIQ 215

  Fly   246 NLFWTRKLARELGCPMYDPTDVVECLRNETWTRIVEVCKAWETYQLVNMKWNYEIDGHFLHNHPT 310
            :|.:          |...|.|                         |::. :|:.:.:||
Human   216 SLIY----------PALQPLD-------------------------VDLP-SYQENSNFL----- 239

  Fly   311 ELIKEGNFNKVPLLISFTANEFDYN----------ANVHLENQHLLHDFASNFVDYA---PELFL 362
                   |....|::.|.:..|..:          .:|.:|:.||.     .||:::   ||.|:
Human   240 -------FLSKSLMVRFWSEYFTTDRSLEKAMLSRQHVPVESSHLF-----KFVNWSSLLPERFI 292

  Fly   363 YRH--------DAQIGEKLKDF 376
            ..|        .:::.:|...|
Human   293 KGHVYNNPNYGSSELAKKYPGF 314

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_609300.1	COesterase	27..528	CDD:395084	60/282 (21%)
AADAC	NP_001077.2	Abhydrolase_3	107..374	CDD:400284	60/282 (21%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	111..113		1/1 (100%)