DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3841 and Ces1g

DIOPT Version :9

Sequence 1:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_067431.2	Gene:	Ces1g / 12623	MGIID:	88378	Length:	565	Species:	Mus musculus

Alignment Length:	555	Identity:	169/555 - (30%)
Similarity:	256/555 - (46%)	Gaps:	105/555 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 WALLLILIGFTTAVTFIGD---DPVVELSLGRIQGD--TMQSFGNKTIYAFRGIRYAQSPVGQLR 68
            |...|.||..|..:: :|.   .|||....|::.|.  |::.| ::.:..|.|:.:|:.|:|.||
Mouse     2 WLCALSLISLTACLS-LGHPSLPPVVHTVHGKVLGKYVTLEGF-SQPVAVFLGVPFAKPPLGSLR 64

  Fly    69 FANPVPETSWGDEVFNATSDSLVCPQPGVVSL----------------MSEDCLKINVFTK---S 114
            ||.|.|...| ..|.:.||...:|.|....:|                .|||||.:|::|.   :
Mouse    65 FAPPEPAEPW-SFVKHTTSYPPLCYQNPEAALRLAELFTNQRKIIPHKFSEDCLYLNIYTPADLT 128

  Fly   115 FEDKFPVMVYIHGGANVLGSGHSSYEAGPQYLLDQDVVFVAFNYRLGALGFLSTNSSETKGNFGF 179
            ...:.||||:||||..|: .|.|:|:..| ..:.::||.|...||||..||.||....::||:|.
Mouse   129 QNSRLPVMVWIHGGGLVI-DGASTYDGVP-LAVHENVVVVVIQYRLGIWGFFSTEDEHSRGNWGH 191

  Fly   180 LDQVMALEWVRDHISHFGGDPELVTIIGISAGSMAVSLHLASPLSAGLFHRAILMSGSATNHFDI 244
            ||||.||.||:|:|::|||:|..|||.|.|||..:||:.:.|||:..||||||..|....|
Mouse   192 LDQVAALHWVQDNIANFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAIAQSSVIFN---- 252

  Fly   245 DNLF------WTRKLARELGCPMYDPTDVVECLRNETWTRIVEVCKAWETYQLVNMKW------- 296
            ..||      ..:|:|...||.......:|.|||.:|...::||.        :.||:
Mouse   253 PCLFGRAARPLAKKIAALAGCKTTTSAAMVHCLRQKTEDELLEVS--------LKMKFGTVDFLG 309

  Fly   297 ----NYE-----IDGHFLHNHPTELIKEGNFNKVPLLISFTANEFDYNANVHLE----NQHLLHD 348
                :|.     |||..|...|.|::.|.:||.||.::....:||.:...:.|:    .:.|...
Mouse   310 DPRESYPFLPTVIDGVLLPKAPEEILAEKSFNTVPYMVGINKHEFGWIIPMFLDFPLSERKLDQK 374

  Fly   349 FASNFVDYAPELFLYRHDAQIGEKL----KDFYLGDNTTEINSENIENFGQIFSDAYIGHGVHRL 409
            .|::.:..|..:.      .|.|||    .:.|||.  ||..:...:.|..:..|  |..||..:
Mouse   375 TAASILWQAYPIL------NISEKLIPAAIEKYLGG--TEDPATMTDLFLDLIGD--IMFGVPSV 429

  Fly   410 VQLASH-------FTPVYYTRMDYVGDQSLSAPLNGENKPVGVGHADDLHYVLPGYWYGPLM--A 465
            :...||       :...|..|..:|.|.. ...|.|:       |||:|..|    |..|.:  .
Mouse   430 IVSRSHRDAGAPTYMYEYQYRPSFVSDDR-PQELLGD-------HADELFSV----WGAPFLKEG 482

  Fly   466 ANDSDVFMMERLTSWFTHFAKTGTPLNSTDI--WP 498
            |::.::.:.:.:..::.:||:.|.| |...:  ||
Mouse   483 ASEEEINLSKMVMKFWANFARNGNP-NGEGLPHWP 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	163/537 (30%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	59/118 (50%)
Ces1g	NP_067431.2	COesterase	24..545	CDD:278561	163/532 (31%)
Ces1g	NP_067431.2	Aes	<121..>239	CDD:223730	54/119 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832615
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	228	1.000	Inparanoid score	I3450
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.790