DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3841 and Cel

DIOPT Version :9

Sequence 1:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_034015.1	Gene:	Cel / 12613	MGIID:	88374	Length:	599	Species:	Mus musculus

Alignment Length:	512	Identity:	147/512 - (28%)
Similarity:	218/512 - (42%)	Gaps:	102/512 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 GRIQG--DTMQSFGNKTIYAFRGIRYAQSPVGQLRFANPVPETSWGDEVFNATSDSLVCPQPGVV 98
            |.::|  ..:...|..::..|:||.:|.:..    ..||.....| .....||:....|.|..:.
Mouse    31 GFVEGVNKKLSLLGGDSVDIFKGIPFATAKT----LENPQRHPGW-QGTLKATNFKKRCLQATIT 90

  Fly    99 ---SLMSEDCLKINVFT----KSFEDKFPVMVYIHGGANVLGSGHSS-------YEAGPQYLLDQ 149
               :...||||.:|::.    |......||||:|:|||.::|||..:       |: |.:.....
Mouse    91 QDNTYGQEDCLYLNIWVPQGRKQVSHNLPVMVWIYGGAFLMGSGQGANFLKNYLYD-GEEIATRG 154

  Fly   150 DVVFVAFNYRLGALGFLSTNSSETKGNFGFLDQVMALEWVRDHISHFGGDPELVTIIGISAGSMA 214
            :|:.|.||||:|.||||||..:...||||..||.||:.||:.:|:.|||||:.:||.|.|||:.:
Mouse   155 NVIVVTFNYRVGPLGFLSTGDANLPGNFGLRDQHMAIAWVKRNIAAFGGDPDNITIFGESAGAAS 219

  Fly   215 VSLHLASPLSAGLFHRAILMSGSATNHFDIDN--LFWTRKLARELGCPMYDPTDVVECLRNETWT 277
            |||...||.:.||..|||..||.|.:.:.|..  |||.:.:|:::|||..|...:..||
Mouse   220 VSLQTLSPYNKGLIRRAISQSGMALSPWAIQKNPLFWAKTIAKKVGCPTEDTGKMAACL------ 278

  Fly   278 RIVEVCKAWETYQLVNMKWNYE----------IDGHFLHNHPTELIKEGNFNKVPLLISFTANEF 332
            :|.:.......|:|...|..|.          |||.|:.:.|..|     :|.       || :.
Mouse   279 KITDPRALTLAYKLPVKKQEYPVVHYLAFIPVIDGDFIPDDPINL-----YNN-------TA-DI 330

  Fly   333 DYNANVHLENQHLLHDFASNFVDYAPELF----LYR----HDAQIGEK----LKDFYLGDNTTEI 385
            ||.|.::..:.||........||...:..    .||    |....|.|    ..|.|......:.
Mouse   331 DYIAGINNMDGHLFATIDVPAVDKTKQTVTEEDFYRLVSGHTVAKGLKGAQATFDIYTESWAQDP 395

  Fly   386 NSENIENFGQIFSD----------AYIGHGVH-----RLVQLASHFT--PVYYTRMDYVGDQSLS 433
            :.||::.....|..          |...|..|     ....|.||.:  |:|
Mouse   396 SQENMKKTVVAFETDVLFLIPTEIALAQHKAHAKSAKTYSYLFSHPSRMPIY------------- 447

  Fly   434 APLNGENKPVGVGHADDLHYVLPGYWYGPLMAANDSDVFMMERLTSWFTHFAKTGTP 490
                  .|.:|..|||||.||. |..:...:.....|..:.:.:.:::|:||::|.|
Mouse   448 ------PKWMGADHADDLQYVF-GKPFATPLGYRPQDRAVSKAMIAYWTNFARSGDP 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	147/512 (29%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	58/125 (46%)
Cel	NP_034015.1	COesterase	26..542	CDD:278561	147/512 (29%)
		Aes	<117..>247	CDD:223730	61/130 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	553..599
		4 X 11 AA tandem repeats, O-glycosylated region	559..588
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832801
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740