DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3841 and Nlgn2

DIOPT Version :9

Sequence 1:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_446444.1	Gene:	Nlgn2 / 117096	RGDID:	621118	Length:	836	Species:	Rattus norvegicus

Alignment Length:	650	Identity:	177/650 - (27%)
Similarity:	275/650 - (42%)	Gaps:	170/650 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 WALLLILIGFTTA------------------VTFIGDD--PVVELSLGRIQGDTMQSFGNK---T 50
            |.|.|.|:|...|                  :..:|::  |||..:.||::| ..:...|:   .
  Rat     2 WLLALCLVGLAGAQRGGGGPGGGAPGGPGLGLGSLGEERFPVVNTAYGRVRG-VRRELNNEILGP 65

  Fly    51 IYAFRGIRYAQSPVGQLRFANPVPETSWGDEVFNATSDSLVCPQ------PGV------------ 97
            :..|.|:.||..|:|..||..|....|| ..|.|||:....|||      |.:
  Rat    66 VVQFLGVPYATPPLGARRFQPPEAPASW-PGVRNATTLPPACPQNLHGALPAIMLPVWFTDNLEA 129

  Fly    98 ----VSLMSEDCLKINVF--------TKSFED--------------KFPVMVYIHGGANVLGSGH 136
                |...|||||.:|::        ||..::              |.|||:::|||:.:.|:|:
  Rat   130 AATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDTDIRDSGKKPVMLFLHGGSYMEGTGN 194

  Fly   137 -------SSYEAGPQYLLDQDVVFVAFNYRLGALGFLSTNSSETKGNFGFLDQVMALEWVRDHIS 194
                   ::|         .:|:....|||||.||||||.....|||:|.|||:.||.|:.::|:
  Rat   195 MFDGSVLAAY---------GNVIVATLNYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWLSENIA 250

  Fly   195 HFGGDPELVTIIGISAGSMAVSLHLASPLSAGLFHRAILMSGSATNHFDID--NLFWTRKLAREL 257
            |||||||.:||.|..||:..|:|.:.|..|.|||.:||..||:|.:.:.::  .|.:||.||.::
  Rat   251 HFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAISSWSVNYQPLKYTRLLAAKV 315

  Fly   258 GCPMYDPTDVVECLRNETWTRIVEVCKAWETYQLVNMKWNYEIDGHFLHNHPTELIKEGNFNKVP 322
            ||...|.|:.|||||.::...:|:.......|.:.   :...:||..:.:.|..|:::|.|....
  Rat   316 GCDREDSTEAVECLRRKSSRELVDQDVQPARYHIA---FGPVVDGDVVPDDPEILMQQGEFLNYD 377

  Fly   323 LLI-------------------SFTANEFDYNANVHLENQHLLHDFASNFVDYAPELFLYRHDAQ 368
            :||                   ..:|:.||:.              .|||||   .|:.|.....
  Rat   378 MLIGVNQGEGLKFVEDSAESEDGVSASAFDFT--------------VSNFVD---NLYGYPEGKD 425

  Fly   369 IGEKLKDFYLGDNTTEINSE-NIENFGQIFSD-AYIGHGVHRLVQLASHFTPVY-YTRMDYVGDQ 430
            :..:...|...|.....|.| ..:....:|:| .::...|......|.:.:||| ||...:
  Rat   426 VLRETIKFMYTDWADRDNGEMRRKTLLALFTDHQWVAPAVATAKLHADYQSPVYFYTFYHH---- 486

  Fly   431 SLSAPLNGENKP--VGVGHADDLHYVLPGYWYG-PLMAAND--------SDVFMMERLTSWFTHF 484
                 ...|.:|  ....|.|:|.||     :| |::.|.|        :||.:...:.:::|:|
  Rat   487 -----CQAEGRPEWADAAHGDELPYV-----FGVPMVGATDLFPCNFSKNDVMLSAVVMTYWTNF 541

  Fly   485 AKTGTPLNSTD----------------IWPPCNSTVLKMLYNGVVTQVGSPGYSNRYAVWDKLFP 533
            ||||.|.....                :|...||...:.|:.|:..:|.....:|:.|.|.:|.|
  Rat   542 AKTGDPNQPVPQDTKFIHTKPNRFEEVVWSKFNSKEKQYLHIGLKPRVRDNYRANKVAFWLELVP 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	167/607 (28%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	54/139 (39%)
Nlgn2	NP_446444.1	COesterase	42..601	CDD:395084	167/603 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	623..661
		Required for interaction with LHFPL4. /evidence=ECO:0000250\|UniProtKB:Q69ZK9	679..699
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	711..735
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	791..836
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336469
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840