DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3841 and Ces2

DIOPT Version :9

Sequence 1:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001258232.1	Gene:	Ces2 / 100910144	RGDID:	6504334	Length:	561	Species:	Rattus norvegicus

Alignment Length:	598	Identity:	182/598 - (30%)
Similarity:	273/598 - (45%)	Gaps:	118/598 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPRFFQLTW------ALLLILIGFTTAVTFIGDD-----PVVELSLGRIQG------DTMQSFGN 48
            |||....:|      .|||:||...      |.|     |:.....|::||      ||...
  Rat     1 MPRNQLHSWLNAVLFGLLLLLIHVQ------GQDSPESSPIRTTHTGQVQGKLDHVKDTKAG--- 56

  Fly    49 KTIYAFRGIRYAQSPVGQLRFANPVPETSWGDEVFNATSDSLVCPQ-------PGVVSL------ 100
              ::.|.||.:|:.|||.||||.|.|...|.. |.:|||...:|.|       .|::.:
  Rat    57 --VHTFLGIPFAKPPVGPLRFAPPEPPEPWSG-VRDATSQPAMCLQNLDILDEVGLLDMKMILSS 118

  Fly   101 --MSEDCLKINVFTKSFE---DKFPVMVYIHGGANVLGSGHSSYEAGPQYLLDQDVVFVAFNYRL 160
              ||||||.:||:..:..   ...||||:|||||.|:|.. |.|: |....:::|:|.|...|||
  Rat   119 ISMSEDCLYLNVYAPAHAREGSNLPVMVWIHGGALVVGMA-SMYD-GSLLTVNEDLVVVTIQYRL 181

  Fly   161 GALGFLSTNSSETKGNFGFLDQVMALEWVRDHISHFGGDPELVTIIGISAGSMAVSLHLASPLSA 225
            |.|||.||.....:||:|:||||.||.||:.:|:||||:|..|||.|.|||..:||.|:.||:|.
  Rat   182 GVLGFFSTGDEHARGNWGYLDQVAALRWVQQNIAHFGGNPNRVTIFGESAGGTSVSSHVISPMSQ 246

  Fly   226 GLFHRAILMSGSATNHFDIDNLFWT--RKLARELGCPMYDPTDVVECLRNETWTRIVEVCKAWET 288
            ||||.||:.||.|.....|.....|  ..:|:..||...|...:|.|||.::...|:.:.|.::.
  Rat   247 GLFHGAIMESGVALLPDLISETSETVSTTVAKLSGCEAMDSEALVRCLRAKSGAEILVINKVFKM 311

  Fly   289 YQLVNMKWNYEIDGHFLHNHPTELIKEGNFNKVPLLISFTANEFDYNANVHLENQHLLHDFASN- 352
            ...|       :||.||..||.||:...:|:.||.:|....:|:.....:.:....::.:.:..
  Rat   312 IPAV-------VDGEFLPRHPKELLASEDFHPVPSIIGVNTDEYCCTIPMVMGTAQIIKELSREN 369

  Fly   353 ----FVDYAPELFLYRHDAQIGEKLKDFYLGDNTTEINSENIENFGQIFSDAYIGHGVHRLVQLA 413
                ..|.|.::.|   ..:.|:.|.:.|:| ||.:..:..|: :.::..|...   |...:|:|
  Rat   370 LQAVLKDTAAQMML---PPECGDLLMEEYMG-NTDDSQTLQIQ-YTEMMGDFLF---VIPALQVA 426

  Fly   414 SHF----TPVYYTRMDYVGDQSLSAPLNGEN-KP--VGVGHADDLHYVLPGYWYGPLMAANDSDV 471
             ||    .|||:....:       ||...:| :|  |...|||::.:|...::.|..:...:.:.
  Rat   427 -HFQRSHAPVYFYEFQH-------APSYFKNVRPPHVKADHADEVPFVFGSFFSGMKLDFTEEER 483

  Fly   472 FMMERLTSWFTHFAKTGTPLNSTDI--WP--------------PCNSTVLKMLYNGVVTQVGSPG 520
            .:..|:..::.:||:.|.| ||..:  ||              |.....||
  Rat   484 LLSRRMMKYWANFARQGNP-NSEGLPYWPALDHDEQYLQLDTHPAVDRALK-------------- 533

  Fly   521 YSNRYAVWDKLFP 533
             :.|...|.|..|
  Rat   534 -ARRLQFWTKTLP 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	169/559 (30%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	62/121 (51%)
Ces2	NP_001258232.1	COesterase	31..540	CDD:278561	168/555 (30%)
Ces2	NP_001258232.1	Aes	<130..>233	CDD:223730	50/104 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336351
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830