DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3841 and ache

DIOPT Version :9

Sequence 1:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_002940088.1	Gene:	ache / 100490673	XenbaseID:	XB-GENE-923160	Length:	600	Species:	Xenopus tropicalis

Alignment Length:	562	Identity:	148/562 - (26%)
Similarity:	230/562 - (40%)	Gaps:	127/562 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TWALLLILIGFTTAVTFIGDDPVVELSLGRIQGDTMQSFGNKTIYAFRGIRYAQSPVGQLRFANP 72
            |.:|||:     .|:|......:|....|:::| ..|...:..:.||.||.:|:.||.::||...
Frog    13 TLSLLLV-----PALTQSDGGLLVSTRSGKVRG-LRQPVLSTHVSAFLGIPFAEPPVDKMRFRRS 71

  Fly    73 VPETSWGDEVFNATSDSLVCPQ------PGVVSL--------MSEDCLKINVFT-KSFEDKFPVM 122
            .|:..|.| |::||:....|.|      ||...:        ||||||.:|::. ........||
Frog    72 EPKKPWTD-VWDATAYPNACYQYFDTLYPGFPGMEMWNPNRPMSEDCLYLNIWVPHPRPSNATVM 135

  Fly   123 VYIHGGANVLGSGHSSYEAGPQYLLDQDVVFVAFNYRLGALGF--LSTNSSETKGNFGFLDQVMA 185
            |:|:||....||.......|......::|:.|:.|||:||.||  |:..|.:..||.|..||.:|
Frog   136 VWIYGGGFYSGSSSLDVYDGRYLCHAENVIVVSMNYRVGAFGFLTLTPGSVDAPGNVGLFDQRLA 200

  Fly   186 LEWVRDHISHFGGDPELVTIIGISAGSMAVSLHLASPLSAGLFHRAILMSGSATNHFDIDNLFW- 249
            |:||:|:|:.|||||..|||.|.|||:::|.:|:.||.|..||.:|.|.|||       .|..|
Frog   201 LQWVQDNIAFFGGDPRTVTIFGESAGAVSVGMHVLSPGSHHLFSKAALQSGS-------PNTPWA 258

  Fly   250 ----------TRKLARELGCPMYDPTDVVECLRNETWTRIVE----VCKAWETYQLVNMKWNYEI 300
                      |..|.:.|.|.|.:.|:::.|||.:....:::    |..|...::...:.   ..
Frog   259 TITPQEARRRTELLGKFLDCRMGNDTELLNCLRVKQPQELIDHEFSVLPAPSVFRFAFVP---VP 320

  Fly   301 DGHFLHNHPTELIKEGNFNKVPLLISFTANEFDY--------------------------NANVH 339
            |..|....|..|:..|.|...||::....||..|                          ..:|.
Frog   321 DADFFPEPPEILMNMGRFKPCPLIMGVNQNEGSYFLLYGAPGFSKNNESLITREEFLGGVKMSVP 385

  Fly   340 LENQHLLHDFASNFVDYAPELFLYRHDAQIGEKLKDFYLGDNT-----TEINSENIENFGQIFSD 399
            ..|...|......:.|:|.|     |......:..|..:||:.     |....:..|...::::.
Frog   386 QANDIALEAVVMQYTDWADE-----HAGVKNREAMDQLVGDHNVICPLTYFAGKVAETGNRVYTY 445

  Fly   400 AYIGHGVHRLVQLASHFTPVYYTRMDYVGDQSLSAPLNGENKPVGVGHADDLHYVLPGYWYGPLM 464
            .:    .||...||   .|.:                      :||.|..::.:|     :|..:
Frog   446 FF----DHRASNLA---WPQW----------------------MGVPHGYEIEFV-----FGLPL 476

  Fly   465 AAN----DSDVFMMERLTSWFTHFAKTGTPLNSTDI----WP 498
            .||    ..:..:..|:..::.:||:||.|....|.    ||
Frog   477 DANLNYTPQEEALSRRMMRYWANFARTGDPNEGNDAHQPRWP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	142/543 (26%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	52/120 (43%)
ache	XP_002940088.1	COesterase	31..549	CDD:395084	142/539 (26%)
ache	XP_002940088.1	AChE_tetra	564..597	CDD:400834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910