DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3841 and Ces1f

DIOPT Version :9

Sequence 1:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001096829.2	Gene:	Ces1f / 100125372	RGDID:	1642419	Length:	561	Species:	Rattus norvegicus

Alignment Length:	583	Identity:	177/583 - (30%)
Similarity:	266/583 - (45%)	Gaps:	104/583 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LILIGFTTAVTF--IGDDPVVELSLGRIQGDTMQSFG-NKTIYAFRGIRYAQSPVGQLRFANPVP 74
            |.|:...|.|.:  ....|||:.:.|::.|..:...| .:::..|.|:.:|:.|:|.||||.|.|
  Rat     6 LFLVSLATCVVYGNPSSPPVVDTTKGKVLGKYVSLEGVTQSVAVFLGVPFAKPPLGSLRFAPPQP 70

  Fly    75 ETSWGDEVFNATSDSLVCPQPGV---------------VSL-MSEDCLKINV-----FTKSFEDK 118
            ...| ..|.|.|:...:|.|...               :.| .|||||.:|:     |||:  .:
  Rat    71 AEPW-SFVKNTTTYPPMCSQDAAKGQRMNDLLTNRKEKIHLEFSEDCLYLNIYTPADFTKN--SR 132

  Fly   119 FPVMVYIHGGANVLGSGHSSYEAGPQYLLDQDVVFVAFNYRLGALGFLSTNSSETKGNFGFLDQV 183
            .||||:||||...|| |.|:|: |......::||.||..||||..||.||....::||:|.||||
  Rat   133 LPVMVWIHGGGMTLG-GASTYD-GRVLSAYENVVVVAIQYRLGIWGFFSTGDEHSRGNWGHLDQV 195

  Fly   184 MALEWVRDHISHFGGDPELVTIIGISAGSMAVSLHLASPLSAGLFHRAILMSGSATNHFDIDNLF 248
            .||.||:|:|::|||||..|||.|.|||..:||:.:.|||:..||||||..||...    :..|.
  Rat   196 AALHWVQDNIANFGGDPGSVTIFGESAGGFSVSVLVLSPLTKNLFHRAISESGVVF----LPGLL 256

  Fly   249 W------TRKLARELGCPMYDPTDVVECLRNETWTRIVEVCKAWETYQLVNMKWNYE-------- 299
            .      .:::|...||.......:|.|||.:|...::|:.|.....:|.:.:.|.|
  Rat   257 TKDVRPAAKQIADMAGCETTTSAIIVHCLRQKTEEELLEIMKKMNLIKLSSQRDNKESYHFLSTV 321

  Fly   300 IDGHFLHNHPTELIKEGNFNKVPLLISFTANEFDY---------NANVHLENQ---HLLHDFASN 352
            :|...|...|.|::.|.|||.||.::.....|..:         .|:|.|:.:   .||..|||.
  Rat   322 VDNVVLPKDPKEILAEKNFNTVPYIVGINKQECGWLLPTMMGFVPADVELDKKMAITLLEKFASL 386

  Fly   353 F---VDYAP-ELFLYRHDAQIGEKLKD---FYLGDNTTEINSENIENFGQIFSDAYIGHGVHRLV 410
            :   .|..| .:..||..:....|::|   .::||.:..|.|..:..             .||
  Rat   387 YGIPEDIIPVAIEKYRKGSDDSIKIRDGILAFIGDVSFSIPSVMVSR-------------DHR-- 436

  Fly   411 QLASHFTPVYYTRMDYVGDQSLSAPLNGENKPVGV--GHADDLHYVLPGYWYG-PLM--AANDSD 470
               ....|.|.....|.  .|.|:|    .:|..|  .|||||:.|     :| |::  .|::.:
  Rat   437 ---DAGAPTYMYEYQYY--PSFSSP----QRPKHVVGDHADDLYSV-----FGAPILRDGASEEE 487

  Fly   471 VFMMERLTSWFTHFAKTGTPLNSTDI--WPPCNSTVLKMLYNGVVTQVGSPGYSNRYAVWDKL 531
            :.:.:.:..::.:||:.|.| |...:  ||..:... :.|..|..||......:...|.|.:|
  Rat   488 IKLSKMVMKFWANFARNGNP-NGRGLPHWPQYDQKE-EYLQIGATTQQSQRLKAEEVAFWTQL 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	171/562 (30%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	62/118 (53%)
Ces1f	NP_001096829.2	COesterase	24..545	CDD:278561	171/560 (31%)
		Aes	<121..>234	CDD:223730	56/116 (48%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	558..561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336509
Domainoid	1	1.000	232	1.000	Domainoid score	I2325
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3341
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.790