DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gcm and GCM2

DIOPT Version :9

Sequence 1:	NP_001260292.1	Gene:	gcm / 34277	FlyBaseID:	FBgn0014179	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_004743.1	Gene:	GCM2 / 9247	HGNCID:	4198	Length:	506	Species:	Homo sapiens

Alignment Length:	488	Identity:	156/488 - (31%)
Similarity:	226/488 - (46%)	Gaps:	121/488 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 IDWDINDSKMP-SVGEFDDFNDWSNGHCRLIYSVQSDEARKHASGWAMRNTNNHNVNILKKSCLG 95
            :.|||||.:|| .:..||.|.:|.:|:.|.|||....:|::|.||||||||||||.:||||||||
Human    19 LSWDINDPQMPQELALFDQFREWPDGYVRFIYSSDEKKAQRHLSGWAMRNTNNHNGHILKKSCLG 83

  Fly    96 VLLCSAKCKLPNGASVHLRPAICDKARRKQQGKQCPNRNCNGRLEIQACRGHCGYPVTHFWRRDG 160
            |::|:..|.||:|:.:.||||||||||.|||.|.||  ||:..||:..||||.|||||:|||.||
Human    84 VVVCTQACTLPDGSRLQLRPAICDKARLKQQKKACP--NCHSALELIPCRGHSGYPVTNFWRLDG 146

  Fly   161 NGIYFQAKGTHDHPRPEAKGSTEARRLLAGGRRVRSLAVMLARESALSDKLSSL-RPTKRQAKTQ 224
            |.|:|||||.|||||||:|..|||||                  ||:..:::|. :|.|::.:..
Human   147 NAIFFQAKGVHDHPRPESKSETEARR------------------SAIKRQMASFYQPQKKRIRES 193

  Fly   225 SIQESKRRRMGASDV--LETKQEL-VVPPTTYLPTSTPTHSTNFNQS------------QGSYVP 274
            ..:|::......|::  ||..::. :|..|::.....|..|  |.:|            ||..:|
Human   194 EAEENQDSSGHFSNIPPLENPEDFDIVTETSFPIPGQPCPS--FPKSDVYKATCDLATFQGDKMP 256

  Fly   275 AGQGSVISQWNREIHYETEDPCYANGMYSYDMLHSPLSAHSSTGSYYQENKPQQLQHSQYQQQLS 339
            ..|     :::....|....||      ||::.:                 |.....|.|
Human   257 PFQ-----KYSSPRIYLPRPPC------SYELAN-----------------PGYTNSSPY----- 288

  Fly   340 PQQHVPVSYDPSQPIS--------SSLQCGMPSYEICDDTSSLTSSSGYCSEDYGYYNGY-LPNS 395
                 |..|..|..|.        ::|||.:.||      ||...|..:.::.:|:.... .|:.
Human   289 -----PTLYKDSTSIPNDTDWVHLNTLQCNVNSY------SSYERSFDFTNKQHGWKPALGKPSL 342

  Fly   396 LDVSNGSQSQ--------NLSQDASFYTTSSEIFSVFESTLNGGGTSGVDLIYDEAT--AYQQHQ 450
            ::.:|..|.|        |......:.||...            |...:..:....|  :||.:|
Human   343 VERTNHGQFQAMATRPYYNPELPCRYLTTPPP------------GAPALQTVITTTTKVSYQAYQ 395

  Fly   451 QQGTFPHLTNYQQEPQD--QMQSADYYYSNTGV 481
                 |....|....::  .:.|.:|...:||:
Human   396 -----PPAMKYSDSVREVKSLSSCNYAPEDTGM 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gcm	NP_001260292.1	GCM	47..186	CDD:281598	89/138 (64%)
GCM2	NP_004743.1	GCM	35..172	CDD:281598	89/138 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	155..213		22/75 (29%)
		C-terminal conserved inhibitory domain (CCID). /evidence=ECO:0000269\|PubMed:27745835	379..395		3/15 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145949
Domainoid	1	1.000	208	1.000	Domainoid score	I2859
eggNOG	1	0.900	-	-		E1_28MJ9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003094
OrthoInspector	1	1.000	-	-		mtm8555
orthoMCL	1	0.900	-	-		OOG6_107695
Panther	1	1.100	-	-	O	PTHR12414
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4583
SonicParanoid	1	1.000	-	-		X4579
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.730