DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gcm and gcm2

DIOPT Version :9

Sequence 1:	NP_001260292.1	Gene:	gcm / 34277	FlyBaseID:	FBgn0014179	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001005603.1	Gene:	gcm2 / 449615	ZFINID:	ZDB-GENE-050127-1	Length:	496	Species:	Danio rerio

Alignment Length:	486	Identity:	151/486 - (31%)
Similarity:	213/486 - (43%)	Gaps:	125/486 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 IDWDINDSKMP-SVGEFDDFNDWSNGHCRLIYSVQSDEARKHASGWAMRNTNNHNVNILKKSCLG 95
            :.|||||.|:| ...::|.|.:|::|:.|.|||.:...|::|.||||||||||||..||||||||
Zfish    21 LTWDINDPKLPQDTKQYDAFQEWTDGYVRYIYSSEDKNAQRHLSGWAMRNTNNHNCQILKKSCLG 85

  Fly    96 VLLCSAKCKLPNGASVHLRPAICDKARRKQQGKQCPNRNCNGRLEIQACRGHCGYPVTHFWRRDG 160
            |::||..|.||:|:.:.||||||||||:|||.|.||  |||..||:..||||.|||||:|||.||
Zfish    86 VVVCSRNCSLPDGSKLQLRPAICDKARQKQQKKLCP--NCNSALELIPCRGHSGYPVTNFWRVDG 148

  Fly   161 NGIYFQAKGTHDHPRPEAKGSTEARRLLAGGRRVRSLAVMLARESALSDKLSSLRPTKRQAKTQS 225
            ..|:|||||.|||||||:|..|||||                  ||:..::|| .|..::.:...
Zfish   149 KAIFFQAKGVHDHPRPESKSETEARR------------------SAVKRRMSS-PPFSQKRRLVE 194

  Fly   226 IQESKRRRMGASDV----LETKQELVVPPTTYLPTSTPTHSTNFN--------QSQGSYVPAGQG 278
            .:..:...|...::    :|..:...:...:..|..|..:.|..|        .:..:.:...|.
Zfish   195 PEPGRYHDMAFPNIHQLTMEGPERFSIIAESNFPIQTQHYPTFQNPEPYKFPYDTHAAAMADAQS 259

  Fly   279 SVISQWNREIHYETEDPC---------YANGMYSYDMLHSPLS-----------------AHSST 317
            |:....|..: |.|..||         ..:|.|...:...|.|                 :|.|:
Zfish   260 SLQKPANHRL-YVTRPPCGYDFAVPGYLGSGPYPAALYKDPSSPQMETEPNKSGSSLSGVSHGSS 323

  Fly   318 --GSYYQENKPQQLQHSQYQQQLSP---------------------QQHVPVSY-DPSQPISSSL 358
              ||:.:.......:|..::|.||.                     ....|..| .|:.|..::|
Zfish   324 PLGSHERSYAESSGKHHGWKQILSKGGYGDRGDYSQLPTNANHHYYNSDYPCRYTGPAAPTPAAL 388

  Fly   359 Q-------------CGMPS--------YEI-----CDDTSSLTSSSGYCS----EDYGY------ 387
            |             |..||        |::     |:......|.:.|..    ||.|.
Zfish   389 QTIITTTTKVSYQPCPKPSVVKYGENIYDVKGLSNCNSILEEPSPNSYSDLKIPEDSGVIKSALS 453

  Fly   388 YNGYLPNSLDVSNGSQSQNLSQDASFYTTSS 418
            |...||..::.|...:....|.    |:.:|
Zfish   454 YQDTLPAKIERSENFEGYRYSS----YSANS 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gcm	NP_001260292.1	GCM	47..186	CDD:281598	89/138 (64%)
gcm2	NP_001005603.1	GCM	37..174	CDD:281598	89/138 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579432
Domainoid	1	1.000	206	1.000	Domainoid score	I2857
eggNOG	1	0.900	-	-		E1_28MJ9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003094
OrthoInspector	1	1.000	-	-		otm25340
orthoMCL	1	0.900	-	-		OOG6_107695
Panther	1	1.100	-	-	O	PTHR12414
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4583
SonicParanoid	1	1.000	-	-		X4579
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.730