DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gcm and Gcm2

DIOPT Version :9

Sequence 1:	NP_001260292.1	Gene:	gcm / 34277	FlyBaseID:	FBgn0014179	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_032130.2	Gene:	Gcm2 / 107889	MGIID:	1861438	Length:	504	Species:	Mus musculus

Alignment Length:	510	Identity:	160/510 - (31%)
Similarity:	216/510 - (42%)	Gaps:	142/510 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 IDWDINDSKMP-SVGEFDDFNDWSNGHCRLIYSVQSDEARKHASGWAMRNTNNHNVNILKKSCLG 95
            :.|||||.:|| ....||.|.:|.:|:.|.|||.|..:|::|.||||||||||||.:||||||||
Mouse    19 LTWDINDPQMPQEPTHFDHFREWPDGYVRFIYSSQEKKAQRHLSGWAMRNTNNHNGHILKKSCLG 83

  Fly    96 VLLCSAKCKLPNGASVHLRPAICDKARRKQQGKQCPNRNCNGRLEIQACRGHCGYPVTHFWRRDG 160
            |::|:..|.|.:|:.:.||||||||||.|||.|.||  ||:..||:..||||.|||||:|||.||
Mouse    84 VVVCARACALKDGSHLQLRPAICDKARLKQQKKACP--NCHSPLELVPCRGHSGYPVTNFWRLDG 146

  Fly   161 NGIYFQAKGTHDHPRPEAKGSTEARRLLAGGRRVRSLAVMLARESALSDKLSSL-RPTKRQA--- 221
            |.|:|||||.|||||||:|..||.||                  |||..:::|. :|.||::
Mouse   147 NAIFFQAKGVHDHPRPESKSETEGRR------------------SALKRQMASFYQPQKRRSGEP 193

  Fly   222 ---KTQSIQESKRRRMGASDVLETKQELVVPPTTYLP-TSTPTHSTNFNQSQGSYV----PAGQG 278
               .||.|    |..:.::..||..:...:...|..| ...|  |.:|..|....|    |..||
Mouse   194 EARSTQDI----RGHLNSTAALEPTELFDMTADTSFPIPGQP--SPSFPNSDVYRVTCDLPTFQG 252

  Fly   279 SVISQWNREIHYETEDPCYANGMYSYDMLHSPLSAHSSTGSYYQENKPQQLQHSQYQQQLSPQQH 343
            .:|..:.:   |......:....:.|::..|.::..|...:.|:::.
Mouse   253 DIILPFQK---YPNPSIYFPGPPWGYELASSGVTGSSPYSTLYKDSS------------------ 296

  Fly   344 VPVSYDPSQPISSSLQCGMPSYEICDDTSSLTSSSGYCSEDYG--------------------YY 388
             .|..||.....:|||..:.||...:.|...|:........:|                    ||
Mouse   297 -EVPDDPDWIPLNSLQYNVSSYGSYERTLDFTARYHSWKPTHGKPSLEEKVDCEQCQAVPTLPYY 360

  Fly   389 N-----GYLPNSLDVSNGSQSQNLSQDASFYTTSSEIFSVFESTLNGGGTSGVDLIYDEATAYQQ 448
            |     .|||                                  :...|:..:..:.....|||.
Mouse   361 NLELPCRYLP----------------------------------VPAAGSQALQTVITTTVAYQA 391

  Fly   449 HQQQGTFPHLTNYQQEPQDQMQSADYYYSNTGVDNSWNIQMDATYHPVNSTDPIY 503
            :|.    |.|.:     .|.||......|             .||...|...|||
Mouse   392 YQH----PALKH-----GDSMQEVSSLAS-------------CTYASENLPMPIY 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gcm	NP_001260292.1	GCM	47..186	CDD:281598	88/138 (64%)
Gcm2	NP_032130.2	GCM	35..172	CDD:281598	88/138 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	155..203		23/69 (33%)
		C-terminal conserved inhibitory domain (CCID). /evidence=ECO:0000250\|UniProtKB:O75603	379..393		3/13 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	438..472
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836027
Domainoid	1	1.000	201	1.000	Domainoid score	I3000
eggNOG	1	0.900	-	-		E1_28MJ9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	217	1.000	Inparanoid score	I3588
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003094
OrthoInspector	1	1.000	-	-		mtm8784
orthoMCL	1	0.900	-	-		OOG6_107695
Panther	1	1.100	-	-	O	PTHR12414
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4583
SonicParanoid	1	1.000	-	-		X4579
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.780