DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mtpalpha and Echs1

DIOPT Version :9

Sequence 1:	NP_609299.1	Gene:	Mtpalpha / 34276	FlyBaseID:	FBgn0028479	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_444349.1	Gene:	Echs1 / 93747	MGIID:	2136460	Length:	290	Species:	Mus musculus

Alignment Length:	241	Identity:	73/241 - (30%)
Similarity:	129/241 - (53%)	Gaps:	25/241 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 NGVLVIKIDSPNAKVNSLGSEVSDEFERVIKDLETNPAVNSAVLISGKPGCFVAGADIGMLE--A 120
            :.|.:|:::.|.| :|:|.:.:.:|..:.::..|.:||| .|::::|....|.|||||..::  .
Mouse    45 SSVGLIQLNRPKA-LNALCNGLIEELNQALETFEQDPAV-GAIVLTGGDKAFAAGADIKEMQNRT 107

  Fly   121 CQTAEEATLISHGAQVMFDRMERSKKPIVAAISGVCLGGGLELALACHYRIATKDSKTKLGLPEV 185
            .|....:..:||     :|.:.|.|||::||::|..||||.|||:.|.  |.....|.:.|.||:
Mouse   108 FQDCYSSKFLSH-----WDHITRVKKPVIAAVNGYALGGGCELAMMCD--IIYAGEKAQFGQPEI 165

  Fly   186 MLGLLPGGGGTVRLPKLTSVPTALDMELTGKQVRADRAKRLGIVDLLVDPLGPGLQPAEQNTIEY 250
            :||.:||.|||.||.:......|::|.|||.::.|..||:.|:|..:.             .:|.
Mouse   166 LLGTIPGAGGTQRLTRAVGKSLAMEMVLTGDRISAQDAKQAGLVSKIF-------------PVEK 217

  Fly   251 LEKTAVQVANDLAS-GKLRVNREKSGLVSKIQSFVMDTDFVKNKIF 295
            |.:.|:|.|..:|| .|:.|...|..:.:..:..:.:.:.::.::|
Mouse   218 LVEEAIQCAEKIASNSKIVVAMAKESVNAAFEMTLTEGNKLEKRLF 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mtpalpha	NP_609299.1	fa_ox_alpha_mit	38..775	CDD:131494	73/241 (30%)
		crotonase-like	52..235	CDD:119339	62/178 (35%)
		3HCDH_N	375..553	CDD:280833
		3HCDH	556..651	CDD:279114
		3HCDH	689..768	CDD:279114
Echs1	NP_444349.1	crotonase-like	32..288	CDD:304874	73/241 (30%)
		PRK05617	36..288	CDD:235533	73/241 (30%)
		Substrate binding. /evidence=ECO:0000250	98..101		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810