DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mtpalpha and EHD3

DIOPT Version :9

Sequence 1:	NP_609299.1	Gene:	Mtpalpha / 34276	FlyBaseID:	FBgn0028479	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_010321.1	Gene:	EHD3 / 851606	SGDID:	S000002443	Length:	500	Species:	Saccharomyces cerevisiae

Alignment Length:	380	Identity:	96/380 - (25%)
Similarity:	158/380 - (41%)	Gaps:	98/380 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LLQN--KCTRALPISAQLLQR-------RRLMSTNP------APVANKHLHTKVVNGVLVIKIDS 67
            :|:|  ||       |||..:       |..|:|.|      ||..   |.| |.:...||.::.
Yeast     1 MLRNTLKC-------AQLSSKYGFKTTTRTFMTTQPQLNVTDAPPV---LFT-VQDTARVITLNR 54

  Fly    68 PNAKVNSLGSEVSDEFERVIKDLETNPAVNSAVL-ISGKPGCFVAGADIGMLEACQTAEEATLIS 131
            |. |:|:|.:|:|:...:.:.:...:...|..:| .|.:|..|.||.|:..:......:|
Yeast    55 PK-KLNALNAEMSESMFKTLNEYAKSDTTNLVILKSSNRPRSFCAGGDVATVAIFNFNKE----- 113

  Fly   132 HGAQVMFDRMERS--------KKPIVAAISGVCLGGGLELALACHYRIATKDSKTKLGLPEVMLG 188
            ....:.|...|.|        .||||..:.|:.:|||:.|::...:||||::  ||..:||:.:|
Yeast   114 FAKSIKFFTDEYSLNFQIATYLKPIVTFMDGITMGGGVGLSIHTPFRIATEN--TKWAMPEMDIG 176

  Fly   189 LLPGGGGTVRLPKLTSVPT-----ALDMELTGKQVRADRAKRLGIVDLLVDPLGPGLQPAEQNTI 248
            ..|..|.|..||::.::..     ||.:.|||:.|....|..||:....|          ....:
Yeast   177 FFPDVGSTFALPRIVTLANSNSQMALYLCLTGEVVTGADAYMLGLASHYV----------SSENL 231

  Fly   249 EYLEKTAVQVA----NDLASGKLRVNREKSGLVSK-IQSFV--MDTDFVKNKIFDTARKQVLKA- 305
            :.|:|...:::    ||..|...      .|:|:: |..||  :..|:|..  :...:..|::|
Yeast   232 DALQKRLGEISPPFNNDPQSAYF------FGMVNESIDEFVSPLPKDYVFK--YSNEKLNVIEAC 288

  Fly   306 ----SNGLYPAPLKILDVIRAGVDKGTDAGYE--AERKGFGE------LSATPES 348
                .||...   .|::.:|.         ||  ||.|.|.:      |:.:|.|
Yeast   289 FNLSKNGTIE---DIMNNLRQ---------YEGSAEGKAFAQEIKTKLLTKSPSS 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mtpalpha	NP_609299.1	fa_ox_alpha_mit	38..775	CDD:131494	88/351 (25%)
		crotonase-like	52..235	CDD:119339	56/196 (29%)
		3HCDH_N	375..553	CDD:280833
		3HCDH	556..651	CDD:279114
		3HCDH	689..768	CDD:279114
EHD3	NP_010321.1	ECH_2	48..386	CDD:406503	80/322 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810