DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mtpalpha and AIM1

DIOPT Version :9

Sequence 1:	NP_609299.1	Gene:	Mtpalpha / 34276	FlyBaseID:	FBgn0028479	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_194630.1	Gene:	AIM1 / 829022	AraportID:	AT4G29010	Length:	721	Species:	Arabidopsis thaliana

Alignment Length:	744	Identity:	236/744 - (31%)
Similarity:	381/744 - (51%)	Gaps:	54/744 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 NGVLVIKIDSPNAKVNSLGSEVSDEFERVIKDLETNPAVNSAVLISGKPGCFVAGADIGMLEACQ 122
            :||.||.|.:|  .||||.|.:....:...:|......|.:.||| |..|.|..|.||.:.:...
plant    14 DGVAVITISNP--PVNSLASPIISGLKEKFRDANQRNDVKAIVLI-GNNGRFSGGFDINVFQQVH 75

  Fly   123 TAEEATLISH-GAQVMFDRMERSKKPIVAAISGVCLGGGLELALACHYRIATKDSKTKLGLPEVM 186
            ...:.:|:.. ..:::.:.||.|:||:|||:.|:.||||||||:|||.|:|.  .|.:|||||:.
plant    76 KTGDLSLMPEVSVELVCNLMEDSRKPVVAAVEGLALGGGLELAMACHARVAA--PKAQLGLPELT 138

  Fly   187 LGLLPGGGGTVRLPKLTSVPTALDMELTGKQVRADRAKRLGIVDLLVDPLGPGLQPAEQNTIEYL 251
            ||::||.|||.|||:|..:..|.||.|..|.:.::...:||::|.||.| |..|
plant   139 LGVIPGFGGTQRLPRLVGLAKATDMILLSKSISSEEGHKLGLIDALVPP-GDVL----------- 191

  Fly   252 EKTAVQVANDLASGK----LRVNR-EKSGLVSKIQSFVMDTDFVKNKIFDTARKQVLKASNGLYP 311
             .|:.:.|.|:|.|:    ..::| :|.|.:|:.::.:.::..:..||          |.|  .|
plant   192 -STSRKWALDIAEGRKPFLQSLHRTDKIGSLSEARAILKNSRQLAKKI----------APN--MP 243

  Fly   312 APLKILDVIRAGVDKGTDAGYEAERKGFGELSATPESKGLIALFRGQTECKK----NRFGKPERP 372
            .....::||..|:..|..:|...|.:.|.:|..:..:|||:.:|..|....|    ...|...||
plant   244 QHHACIEVIEEGIIHGGYSGVLKEAEVFKQLVLSDTAKGLVHVFFAQRATSKVPNVTDVGLKPRP 308

  Fly   373 VKTVGVLGAGLMGAGIVQVSVDKGYQVVMKDATEAGLARGIGQVQKGLETAVKRKRISALERDQT 437
            :|.|.|:|.||||:||....:....:||:|:.....|.:||..|:..:::.|.|.:::..:..:.
plant   309 IKKVAVIGGGLMGSGIATALLLSNIRVVLKEINSEFLMKGIKSVEANMKSLVSRGKLTQDKAGKA 373

  Fly   438 LASLRPTLDYSDFKNADIIIEAVFEDIKVKHRVIKELEAVVPEHCVIATNTSAIPITKIAAGSSR 502
            |:..:..|||::|.:.|::||||.|:|::|..:.||:|.|...||::|:|||.|.:..|...::.
plant   374 LSLFKGVLDYTEFNDVDMVIEAVIENIQLKQNIFKEIEKVCSPHCILASNTSTIDLDVIGEKTNS 438

  Fly   503 PEKVVGMHYFSPVDKMQLLEIITHPGTSKDTIAQAVAVGLKQGKVVITVGDGPGFYTTRILSTML 567
            .:::||.|:|||...|.||||:....||...|...:|||....||.:.||:..||...|......
plant   439 KDRIVGAHFFSPAHLMPLLEIVRSKNTSAQVILDLMAVGKAIKKVPVVVGNCIGFAVNRTFFPYS 503

  Fly   568 SEAIRLLQEGVDPKDLDQYTKKFGFPVGAATLADEVGIDVGSHIAVDLAKAFGERFSGGNLEVMN 632
            ..|..|...|||...:|.....||.|:|...|.|..|..:|..:....||.:|:|..   ...|.
plant   504 QAAHMLANLGVDLFRIDSVITSFGLPLGPFQLGDLAGHGIGLAVGPIYAKVYGDRMF---RSPMT 565

  Fly   633 DLVL-AGFLGRKSGKGIFLYDGQKRGTRP-VNNDALEIVKQKYALVS-KGANAPEDLTLRMVSRF 694
            :|:| :|..|:.:|:|.::|:   :|::| .:...|.||::...|.: .....|..:|.:.:...
plant   566 ELLLKSGRNGKINGRGYYIYE---KGSKPKPDPSVLSIVEKSRKLTNIMPGGKPISVTDKEIVEM 627

  Fly   695 I-----NEAVLCLEEKILDSPLEGDVGAVFGLGFPPFSGGPFRWVDQYGAGKLVSKMQSYAELYG 754
            |     |||...|:|.::....:.|:.:|.|:.||.:.||...|.|..|...:..:::..:|.||
plant   628 ILFPVVNEACRVLDEGVVIRASDLDIASVLGMSFPSYRGGIVFWADTVGPKYIYERLKKLSETYG 692

  Fly   755 APFKPAQTLLDMAKDPSKKFYPKTGSSKL 783
            :.|||::.|.:.|.:.......|:..|||
plant   693 SFFKPSRYLEERAMNGMLLSESKSSRSKL 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mtpalpha	NP_609299.1	fa_ox_alpha_mit	38..775	CDD:131494	232/734 (32%)
		crotonase-like	52..235	CDD:119339	72/177 (41%)
		3HCDH_N	375..553	CDD:280833	63/177 (36%)
		3HCDH	556..651	CDD:279114	28/95 (29%)
		3HCDH	689..768	CDD:279114	23/83 (28%)
AIM1	NP_194630.1	fadJ	8..708	CDD:236864	232/729 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	138	1.000	Domainoid score	I1570
eggNOG	1	0.900	-	-		E1_COG1024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	340	1.000	Inparanoid score	I643
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D219667at2759
OrthoFinder	1	1.000	-	-		FOG0001577
OrthoInspector	1	1.000	-	-		otm3010
orthoMCL	1	0.900	-	-		OOG6_101291
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1128
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.770