DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mtpalpha and hadhab

DIOPT Version :9

Sequence 1:	NP_609299.1	Gene:	Mtpalpha / 34276	FlyBaseID:	FBgn0028479	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_001082906.1	Gene:	hadhab / 793834	ZFINID:	ZDB-GENE-041111-204	Length:	763	Species:	Danio rerio

Alignment Length:	762	Identity:	440/762 - (57%)
Similarity:	559/762 - (73%)	Gaps:	15/762 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RALPISAQLLQR---------RRLMSTNPAPVANKHLHTKVVNGVLVIKIDSPNAKVNSLGSEVS 80
            |||...::|..|         ||........:|..|:..:|...|.|::::.|.||||:|..::.
Zfish     5 RALGSLSRLTTRRYTLFPGVTRRTFKFAACMMARTHVSYEVKGDVAVVRMNDPTAKVNTLSVQMQ 69

  Fly    81 DEFERVIKDLETNPAVNSAVLISGKPGCFVAGADIGMLEACQTAEEATLISHGAQVMFDRMERSK 145
            .:...|:.::..|.||.|.||||.|||||:|||||.|::||:||||.|.:|...|.||:::|:|.
Zfish    70 KDMTEVMDEVWGNSAVQSVVLISSKPGCFIAGADISMIKACKTAEEVTGLSQEGQRMFEKIEKSP 134

  Fly   146 KPIVAAISGVCLGGGLELALACHYRIATKDSKTKLGLPEVMLGLLPGGGGTVRLPKLTSVPTALD 210
            |||||||:|.|||||||.|:||.||||||..||.||.||||||||||.|||.||||:..:|:|.|
Zfish   135 KPIVAAINGSCLGGGLEFAIACQYRIATKSKKTVLGCPEVMLGLLPGAGGTQRLPKMLGLPSAFD 199

  Fly   211 MELTGKQVRADRAKRLGIVDLLVDPLGPGLQPAEQNTIEYLEKTAVQVANDLASGKLRVNREKSG 275
            :.|||:.:|||:||::|:|..|||.|||||:..|:.||||||:.||:.|..||..|:.:.:|| |
Zfish   200 VMLTGRSIRADKAKKMGLVHQLVDTLGPGLKSPEERTIEYLEEVAVEAARGLAQKKITLTKEK-G 263

  Fly   276 LVSKIQSFVMDTDFVKNKIFDTARKQVLKASNGLYPAPLKILDVIRAGVDKGTDAGYEAERKGFG 340
            .:.|||.:||...||:.:|::|..|:|:|.:.|||||||||::.::|||::|...||..|.:.||
Zfish   264 WMQKIQDYVMSYPFVRQQIYNTVEKKVMKQTKGLYPAPLKIIESVKAGVEQGPTTGYLVESQQFG 328

  Fly   341 ELSATPESKGLIALFRGQTECKKNRFGKPERPVKTVGVLGAGLMGAGIVQVSVDKGYQVVMKDAT 405
            :|:.|.|||.||.|:.||..|||||||.||:.|||:.:||||||||||.||:||||...::||.|
Zfish   329 KLAMTNESKALIGLYHGQVACKKNRFGTPEKEVKTLAILGAGLMGAGIAQVTVDKGIHTILKDTT 393

  Fly   406 EAGLARGIGQVQKGLETAVKRKRISALERDQTLASLRPTLDYSDFKNADIIIEAVFEDIKVKHRV 470
            ..||:||..||.|||....|:|.:::.|||..|::|...|||:.|..||:||||||||:.:||:|
Zfish   394 VDGLSRGEQQVFKGLNDKTKKKSLTSFERDTFLSNLTGQLDYNGFNKADMIIEAVFEDLSIKHKV 458

  Fly   471 IKELEAVVPEHCVIATNTSAIPITKIAAGSSRPEKVVGMHYFSPVDKMQLLEIITHPGTSKDTIA 535
            :||:|||:|.||:.||||||:||..|||.|.||:|||||||||||||||||||||...|||||.|
Zfish   459 LKEVEAVIPPHCIFATNTSALPIKDIAAVSKRPDKVVGMHYFSPVDKMQLLEIITTDKTSKDTTA 523

  Fly   536 QAVAVGLKQGKVVITVGDGPGFYTTRILSTMLSEAIRLLQEGVDPKDLDQYTKKFGFPVGAATLA 600
            .|||||||||||:|.|||||||||||.|:.||:||:|:||||.|||.||..|..|||||||||||
Zfish   524 SAVAVGLKQGKVIIVVGDGPGFYTTRCLAPMLAEAVRILQEGTDPKKLDSLTTGFGFPVGAATLA 588

  Fly   601 DEVGIDVGSHIAVDLAKAFGERFSGGNLEVMNDLVLAGFLGRKSGKGIFLYD-GQKRGTRPVNND 664
            |||||||.:|:|.||.||||.||.|||:|.:..:|..||.|||||||.::|. |.||  |.||.:
Zfish   589 DEVGIDVAAHVAEDLGKAFGSRFGGGNVEFLKSMVEKGFKGRKSGKGCYVYQPGLKR--RDVNTE 651

  Fly   665 ALEIVKQKYALVSKGA-NAPEDLTLRMVSRFINEAVLCLEEKILDSPLEGDVGAVFGLGFPPFSG 728
            ||||: :.|.|....| ::..|:..|:||||:|||||||:|.||.:|:|||:||||||||||..|
Zfish   652 ALEIL-EAYKLTPNAAISSDSDIQYRLVSRFVNEAVLCLQEGILANPVEGDIGAVFGLGFPPCLG 715

  Fly   729 GPFRWVDQYGAGKLVSKMQSYAELYGAPFKPAQTLLDMAKDPSKKFY 775
            ||||:||.:||.|||.||:.:.|::|..|.|.|.|||.|:||||||:
Zfish   716 GPFRFVDSFGADKLVEKMRRFEEVFGNQFTPCQLLLDHARDPSKKFH 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mtpalpha	NP_609299.1	fa_ox_alpha_mit	38..775	CDD:131494	433/738 (59%)
		crotonase-like	52..235	CDD:119339	102/182 (56%)
		3HCDH_N	375..553	CDD:280833	115/177 (65%)
		3HCDH	556..651	CDD:279114	64/94 (68%)
		3HCDH	689..768	CDD:279114	51/78 (65%)
hadhab	NP_001082906.1	fa_ox_alpha_mit	27..762	CDD:131494	433/738 (59%)
		crotonase-like	41..251	CDD:119339	118/209 (56%)
		3HCDH_N	363..541	CDD:280833	115/177 (65%)
		3HCDH	544..639	CDD:279114	64/94 (68%)
		3HCDH	676..>750	CDD:279114	48/73 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596061
Domainoid	1	1.000	232	1.000	Domainoid score	I2347
eggNOG	1	0.900	-	-		E1_COG1024
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H152
Inparanoid	1	1.050	855	1.000	Inparanoid score	I414
OMA	1	1.010	-	-		QHG63238
OrthoDB	1	1.010	-	-		D134602at33208
OrthoFinder	1	1.000	-	-		FOG0001577
OrthoInspector	1	1.000	-	-		otm26343
orthoMCL	1	0.900	-	-		OOG6_101291
Panther	1	1.100	-	-	LDO	PTHR43612
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4232
SonicParanoid	1	1.000	-	-		X1128
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800