DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mtpalpha and hadhaa

DIOPT Version :9

Sequence 1:	NP_609299.1	Gene:	Mtpalpha / 34276	FlyBaseID:	FBgn0028479	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_001098746.1	Gene:	hadhaa / 553401	ZFINID:	ZDB-GENE-031222-5	Length:	761	Species:	Danio rerio

Alignment Length:	762	Identity:	430/762 - (56%)
Similarity:	553/762 - (72%)	Gaps:	4/762 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SRQQLLQNKCTRALPISAQLLQRRRLMSTNPAPVANKHLHTKVVNGVLVIKIDSPNAKVNSLGSE 78
            |.:.||...||...  |:.....:|.:|.:.|.:|..|:..:|.:.|.|::|:.|.:|||:|...
Zfish     3 SARLLLARGCTGVK--SSFTGHGQRSLSVSSAVLARTHVSYEVKDNVAVVRINDPTSKVNTLSKH 65

  Fly    79 VSDEFERVIKDLETNPAVNSAVLISGKPGCFVAGADIGMLEACQTAEEATLISHGAQVMFDRMER 143
            :..|...|:.::..|.:|.||||||.|||||:|||||.|::||.||||.|.:|...|.||:::|:
Zfish    66 MQAEMVEVMNEVWGNSSVKSAVLISRKPGCFIAGADINMIQACTTAEEVTSLSQAGQKMFEQIEK 130

  Fly   144 SKKPIVAAISGVCLGGGLELALACHYRIATKDSKTKLGLPEVMLGLLPGGGGTVRLPKLTSVPTA 208
            |..||||||:|.|||||||.|:||.||||||..||.||.||||||||||.|||.||||:..:|.|
Zfish   131 SPIPIVAAINGSCLGGGLEFAIACQYRIATKSKKTVLGTPEVMLGLLPGAGGTQRLPKMVGLPAA 195

  Fly   209 LDMELTGKQVRADRAKRLGIVDLLVDPLGPGLQPAEQNTIEYLEKTAVQVANDLASGKLRVNREK 273
            .||.|||:.:|||:||::|:|..|||||||||:..|:.||||||:.||..|..||:.|:.:.::|
Zfish   196 FDMMLTGRNIRADKAKKMGLVHQLVDPLGPGLKSPEERTIEYLEEVAVDFAKGLAAKKVTLEKKK 260

  Fly   274 SGLVSKIQSFVMDTDFVKNKIFDTARKQVLKASNGLYPAPLKILDVIRAGVDKGTDAGYEAERKG 338
             ||:.|:|.|||....|:.:|:.|...:|:|.|.|||||||||::.|:.|::||..|||.||.:.
Zfish   261 -GLMQKVQDFVMGLSLVRQQIYKTVHGKVMKQSKGLYPAPLKIIECIQTGIEKGNAAGYLAEAQN 324

  Fly   339 FGELSATPESKGLIALFRGQTECKKNRFGKPERPVKTVGVLGAGLMGAGIVQVSVDKGYQVVMKD 403
            ||:|:.:.||:.||.|:.||..||||.||||||.||.:.:||||||||||.||::|||...::||
Zfish   325 FGQLAMSSESRALIGLYHGQVACKKNHFGKPEREVKNLAILGAGLMGAGIAQVTIDKGVATILKD 389

  Fly   404 ATEAGLARGIGQVQKGLETAVKRKRISALERDQTLASLRPTLDYSDFKNADIIIEAVFEDIKVKH 468
            .|..|||||..||.|||....|:|.::..|||..::.|...|||..|:.||::|||||||:.:||
Zfish   390 TTLEGLARGEQQVYKGLNDKTKKKSLTTFERDGIMSKLSGQLDYHGFEKADMVIEAVFEDLAIKH 454

  Fly   469 RVIKELEAVVPEHCVIATNTSAIPITKIAAGSSRPEKVVGMHYFSPVDKMQLLEIITHPGTSKDT 533
            :|:||:|||:|.||:.||||||:||..|||.|.|||||:||||||||||||||||||...|||||
Zfish   455 KVLKEVEAVIPPHCIFATNTSALPIKDIAAASKRPEKVIGMHYFSPVDKMQLLEIITTDKTSKDT 519

  Fly   534 IAQAVAVGLKQGKVVITVGDGPGFYTTRILSTMLSEAIRLLQEGVDPKDLDQYTKKFGFPVGAAT 598
            .|.|||:||||||:::.|||||||||||.|:.||:||:|:|||||.||.||..|..||||||.||
Zfish   520 TASAVAIGLKQGKLIVVVGDGPGFYTTRCLAPMLAEAVRILQEGVGPKKLDSLTTGFGFPVGLAT 584

  Fly   599 LADEVGIDVGSHIAVDLAKAFGERFSGGNLEVMNDLVLAGFLGRKSGKGIFLYDGQKRGTRPVNN 663
            |||||||||.:|:|.||.||||.||.|||::.:..:|..||.|||||||.::| |.|...:.||:
Zfish   585 LADEVGIDVAAHVAEDLGKAFGARFGGGNVDFLKTMVQKGFKGRKSGKGCYVY-GAKSKEKKVNS 648

  Fly   664 DALEIVKQKYALVSKGANAPEDLTLRMVSRFINEAVLCLEEKILDSPLEGDVGAVFGLGFPPFSG 728
            :|.||:|..........::.||:..|:||||:|||||||:|.||..|::||:||||||||||..|
Zfish   649 EAEEILKSFKLTAPPAVSSDEDIQYRLVSRFVNEAVLCLQEGILADPIQGDIGAVFGLGFPPCLG 713

  Fly   729 GPFRWVDQYGAGKLVSKMQSYAELYGAPFKPAQTLLDMAKDPSKKFY 775
            ||||:||.|||.||:.||:.:.|:||..|.|.|.|||.||:.||:|:
Zfish   714 GPFRFVDSYGADKLIQKMKRFEEVYGNQFSPCQLLLDHAKNTSKRFH 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mtpalpha	NP_609299.1	fa_ox_alpha_mit	38..775	CDD:131494	423/736 (57%)
		crotonase-like	52..235	CDD:119339	103/182 (57%)
		3HCDH_N	375..553	CDD:280833	109/177 (62%)
		3HCDH	556..651	CDD:279114	62/94 (66%)
		3HCDH	689..768	CDD:279114	51/78 (65%)
hadhaa	NP_001098746.1	fa_ox_alpha_mit	25..760	CDD:131494	423/736 (57%)
		crotonase-like	39..249	CDD:119339	120/209 (57%)
		3HCDH_N	361..539	CDD:280833	109/177 (62%)
		3HCDH	542..637	CDD:279114	62/94 (66%)
		3HCDH	674..>750	CDD:279114	49/75 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596060
Domainoid	1	1.000	232	1.000	Domainoid score	I2347
eggNOG	1	0.900	-	-		E1_COG1024
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H152
Inparanoid	1	1.050	855	1.000	Inparanoid score	I414
OMA	1	1.010	-	-		QHG63238
OrthoDB	1	1.010	-	-		D134602at33208
OrthoFinder	1	1.000	-	-		FOG0001577
OrthoInspector	1	1.000	-	-		otm26343
orthoMCL	1	0.900	-	-		OOG6_101291
Panther	1	1.100	-	-	O	PTHR43612
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4232
SonicParanoid	1	1.000	-	-		X1128
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800