DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mtpalpha and HADHA

DIOPT Version :9

Sequence 1:	NP_609299.1	Gene:	Mtpalpha / 34276	FlyBaseID:	FBgn0028479	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_000173.2	Gene:	HADHA / 3030	HGNCID:	4801	Length:	763	Species:	Homo sapiens

Alignment Length:	779	Identity:	430/779 - (55%)
Similarity:	560/779 - (71%)	Gaps:	21/779 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSATRFLSAVGQISRQQLLQNK---CTRALPISAQLLQRRRLMSTNPAPVANKHLHTKVVNGVLV 62
            |.|.|.:..:.:.|..::|:::   | |....|:.||.|             .|::..|...|.|
Human     1 MVACRAIGILSRFSAFRILRSRGYIC-RNFTGSSALLTR-------------THINYGVKGDVAV 51

  Fly    63 IKIDSPNAKVNSLGSEVSDEFERVIKDLETNPAVNSAVLISGKPGCFVAGADIGMLEACQTAEEA 127
            ::|:|||:|||:|..|:..||..|:.::..:..:.||||||.|||||:|||||.||.||:|.:|.
Human    52 VRINSPNSKVNTLSKELHSEFSEVMNEIWASDQIRSAVLISSKPGCFIAGADINMLAACKTLQEV 116

  Fly   128 TLISHGAQVMFDRMERSKKPIVAAISGVCLGGGLELALACHYRIATKDSKTKLGLPEVMLGLLPG 192
            |.:|..||.:.:::|:|.|||||||:|.|||||||:|::|.|||||||.||.||.|||:||.|||
Human   117 TQLSQEAQRIVEKLEKSTKPIVAAINGSCLGGGLEVAISCQYRIATKDRKTVLGTPEVLLGALPG 181

  Fly   193 GGGTVRLPKLTSVPTALDMELTGKQVRADRAKRLGIVDLLVDPLGPGLQPAEQNTIEYLEKTAVQ 257
            .|||.||||:..||.||||.|||:.:||||||::|:||.||:||||||:|.|:.||||||:.|:.
Human   182 AGGTQRLPKMVGVPAALDMMLTGRSIRADRAKKMGLVDQLVEPLGPGLKPPEERTIEYLEEVAIT 246

  Fly   258 VANDLASGKLRVNREKSGLVSKIQSFVMDTDFVKNKIFDTARKQVLKASNGLYPAPLKILDVIRA 322
            .|..||..|:...|:| |||.|:.::.|...||:.:::....::|.|.:.|||||||||:||::.
Human   247 FAKGLADKKISPKRDK-GLVEKLTAYAMTIPFVRQQVYKKVEEKVRKQTKGLYPAPLKIIDVVKT 310

  Fly   323 GVDKGTDAGYEAERKGFGELSATPESKGLIALFRGQTECKKNRFGKPERPVKTVGVLGAGLMGAG 387
            |:::|:||||..|.:.||||..|.|||.|:.|:.||..||||:||.|::.||.:.:|||||||||
Human   311 GIEQGSDAGYLCESQKFGELVMTKESKALMGLYHGQVLCKKNKFGAPQKDVKHLAILGAGLMGAG 375

  Fly   388 IVQVSVDKGYQVVMKDATEAGLARGIGQVQKGLETAVKRKRISALERDQTLASLRPTLDYSDFKN 452
            |.|||||||.:.::||||...|.||..||.|||...||:|.:::.|||...::|...|||..|:.
Human   376 IAQVSVDKGLKTILKDATLTALDRGQQQVFKGLNDKVKKKALTSFERDSIFSNLTGQLDYQGFEK 440

  Fly   453 ADIIIEAVFEDIKVKHRVIKELEAVVPEHCVIATNTSAIPITKIAAGSSRPEKVVGMHYFSPVDK 517
            ||::|||||||:.:||||:||:|||:|:||:.|:||||:||::|||.|.|||||:||||||||||
Human   441 ADMVIEAVFEDLSLKHRVLKEVEAVIPDHCIFASNTSALPISEIAAVSKRPEKVIGMHYFSPVDK 505

  Fly   518 MQLLEIITHPGTSKDTIAQAVAVGLKQGKVVITVGDGPGFYTTRILSTMLSEAIRLLQEGVDPKD 582
            ||||||||...|||||.|.|||||||||||:|.|.|||||||||.|:.|:||.||:||||||||.
Human   506 MQLLEIITTEKTSKDTSASAVAVGLKQGKVIIVVKDGPGFYTTRCLAPMMSEVIRILQEGVDPKK 570

  Fly   583 LDQYTKKFGFPVGAATLADEVGIDVGSHIAVDLAKAFGERFSGGNLEVMNDLVLAGFLGRKSGKG 647
            ||..|..||||||||||.||||:||..|:|.||.|.|||||.|||.|::..:|..||||||||||
Human   571 LDSLTTSFGFPVGAATLVDEVGVDVAKHVAEDLGKVFGERFGGGNPELLTQMVSKGFLGRKSGKG 635

  Fly   648 IFLY-DGQKRGTRPVNNDALEIVKQKYALVSKGANAPEDLTLRMVSRFINEAVLCLEEKILDSPL 711
            .::| :|.||  :.:|:|...|:...........::.||:..|:|:||:||||:||:|.||.:|.
Human   636 FYIYQEGVKR--KDLNSDMDSILASLKLPPKSEVSSDEDIQFRLVTRFVNEAVMCLQEGILATPA 698

  Fly   712 EGDVGAVFGLGFPPFSGGPFRWVDQYGAGKLVSKMQSYAELYGAPFKPAQTLLDMAKDPSKKFY 775
            |||:||||||||||..|||||:||.|||.|:|.:::.|...||..|.|.|.|.|.|..|:||||
Human   699 EGDIGAVFGLGFPPCLGGPFRFVDLYGAQKIVDRLKKYEAAYGKQFTPCQLLADHANSPNKKFY 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mtpalpha	NP_609299.1	fa_ox_alpha_mit	38..775	CDD:131494	417/737 (57%)
		crotonase-like	52..235	CDD:119339	106/182 (58%)
		3HCDH_N	375..553	CDD:280833	114/177 (64%)
		3HCDH	556..651	CDD:279114	64/94 (68%)
		3HCDH	689..768	CDD:279114	47/78 (60%)
HADHA	NP_000173.2	fa_ox_alpha_mit	27..762	CDD:131494	422/750 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159822
Domainoid	1	1.000	232	1.000	Domainoid score	I2432
eggNOG	1	0.900	-	-		E1_COG1024
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H152
Inparanoid	1	1.050	847	1.000	Inparanoid score	I440
Isobase	1	0.950	-	0	Normalized mean entropy	S2122
OMA	1	1.010	-	-		QHG63238
OrthoDB	1	1.010	-	-		D134602at33208
OrthoFinder	1	1.000	-	-		FOG0001577
OrthoInspector	1	1.000	-	-		oto90571
orthoMCL	1	0.900	-	-		OOG6_101291
Panther	1	1.100	-	-	LDO	PTHR43612
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4232
SonicParanoid	1	1.000	-	-		X1128
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750