DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mtpalpha and Eci2

DIOPT Version :9

Sequence 1:	NP_609299.1	Gene:	Mtpalpha / 34276	FlyBaseID:	FBgn0028479	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_001006967.1	Gene:	Eci2 / 291075	RGDID:	1359427	Length:	391	Species:	Rattus norvegicus

Alignment Length:	306	Identity:	62/306 - (20%)
Similarity:	109/306 - (35%)	Gaps:	44/306 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SAVGQISRQQLLQNKCTRALPISAQLLQRRRLMSTNPAPVANKHLHTKVV-----NGVLVIKIDS 67
            :|:|.:.::...||    .:.:.:.|.......|........|...:|.:     .|:..|..:.
  Rat    95 NALGSLPKETARQN----YVDLVSSLSSSSEASSQGKGGADGKAQESKGILVTSEGGITKITFNR 155

  Fly    68 PNAKVNSLGSEVSDEFERVIKDLETNPAVNSAVLISGKPGCFVAGADI--------GMLEACQTA 124
            |:.| |::..::..:....:|:..|:..|  ..:.:|....:.:|.|:        ||.||..
  Rat   156 PSKK-NAITFQMYQDIILALKNASTDDTV--ITVFTGAGDYYSSGNDLTNFTSASGGMEEAAN-- 215

  Fly   125 EEATLISHGAQVMFDRMERSKKPIVAAISGVCLGGGLELALACHYRIATKDSKTKLGLPEVMLGL 189
            :.|.::........|    ..||:||.::|..:|..:.| |.....:...|..| ...|...||.
  Rat   216 KGAIVLREFVNTFID----FPKPLVAVVNGPAVGISVTL-LGLFDAVYASDRAT-FHTPFSHLGQ 274

  Fly   190 LPGGGGTVRLPKLTSVPTALDMELTGKQVRADRAKRLGIVDLLVD----------------PLGP 238
            .|....:...||:.....|.:|.|.||::.|..|...|:|..:..                .|.|
  Rat   275 SPEACSSYTFPKMMGSAKAAEMLLFGKKLTAREAWAQGLVTEVFPESTFETEVWTRLKTYAKLPP 339

  Fly   239 GLQPAEQNTIEYLEKTAVQVANDLASGKLRVNREKSGLVSKIQSFV 284
            ......:..|...||..:...|:.....||........::.|.|||
  Rat   340 NSMRISKELIRKNEKEKLHAVNEEECTTLRARWLSEECINAIMSFV 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mtpalpha	NP_609299.1	fa_ox_alpha_mit	38..775	CDD:131494	57/276 (21%)
		crotonase-like	52..235	CDD:119339	43/211 (20%)
		3HCDH_N	375..553	CDD:280833
		3HCDH	556..651	CDD:279114
		3HCDH	689..768	CDD:279114
Eci2	NP_001006967.1	ACBP	38..113	CDD:279259	4/21 (19%)
		Acyl-CoA binding. /evidence=ECO:0000250	64..68
		crotonase-like	134..389	CDD:304874	55/263 (21%)
		ECH-like	149..319		41/180 (23%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q05871	196..200		1/3 (33%)
		Microbody targeting signal. /evidence=ECO:0000255	389..391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900