DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mtpalpha and Eci2

DIOPT Version :9

Sequence 1:	NP_609299.1	Gene:	Mtpalpha / 34276	FlyBaseID:	FBgn0028479	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_001103801.1	Gene:	Eci2 / 23986	MGIID:	1346064	Length:	391	Species:	Mus musculus

Alignment Length:	280	Identity:	60/280 - (21%)
Similarity:	111/280 - (39%)	Gaps:	42/280 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SAVGQISRQQLLQNKCTRALPISAQLLQRRRLMSTNPAPVANKH------LHTKVV-----NGVL 61
            :|:|.:.::...||.......:|          |::.||...|.      ..:|.:     :|:.
Mouse    95 NALGSLPKETARQNYVDLVSSLS----------SSSEAPSQGKRGADEKARESKDILVTSEDGIT 149

  Fly    62 VIKIDSPNAKVNSLGSEVSDEFERVIKDLETNPAVNSAVLISGKPGCFVAGADI-GMLEACQTAE 125
            .|..:.|..| |::..::..:....:|:..|:..|  ..:.:|....:.:|.|: ....|....|
Mouse   150 KITFNRPTKK-NAISFQMYRDIILALKNASTDNTV--MAVFTGTGDYYCSGNDLTNFTSATGGIE 211

  Fly   126 EATLISHGAQVMFDRMER---SKKPIVAAISGVCLGGGLELALACHYRIATKDSKTKLGLPEVML 187
            ||.  |:||.::.|.:..   ..||:||.::|..:|..:.| |.....:...|..| ...|...|
Mouse   212 EAA--SNGAVLLRDFVNSFIDFPKPLVAVVNGPAVGISVTL-LGLFDAVFASDRAT-FHTPFSQL 272

  Fly   188 GLLPGGGGTVRLPKLTSVPTALDMELTGKQVRADRAKRLGIVDLLVDPLGPGLQPAEQNTIEYLE 252
            |..|....:...||:.....|.:|.|.||::.|..|...|:|          .:...::|.|...
Mouse   273 GQSPEACSSYTFPKMMGSAKAAEMLLFGKKLTAREAWAQGLV----------TEVFPESTFETEV 327

  Fly   253 KTAVQVANDLASGKLRVNRE 272
            .|.::....|....:|:::|
Mouse   328 WTRLKTYAKLPPNAMRISKE 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mtpalpha	NP_609299.1	fa_ox_alpha_mit	38..775	CDD:131494	55/250 (22%)
		crotonase-like	52..235	CDD:119339	45/191 (24%)
		3HCDH_N	375..553	CDD:280833
		3HCDH	556..651	CDD:279114
		3HCDH	689..768	CDD:279114
Eci2	NP_001103801.1	ACBP	38..113	CDD:279259	4/17 (24%)
		Acyl-CoA binding. /evidence=ECO:0000250	64..68
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..136		5/29 (17%)
		crotonase-like	139..389	CDD:304874	50/226 (22%)
		ECH-like	149..319		43/186 (23%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q05871	196..200		1/3 (33%)
		Microbody targeting signal. /evidence=ECO:0000255	389..391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900