DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mtpalpha and ech-9

DIOPT Version :9

Sequence 1:	NP_609299.1	Gene:	Mtpalpha / 34276	FlyBaseID:	FBgn0028479	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_501875.2	Gene:	ech-9 / 184065	WormBaseID:	WBGene00001158	Length:	434	Species:	Caenorhabditis elegans

Alignment Length:	433	Identity:	121/433 - (27%)
Similarity:	200/433 - (46%)	Gaps:	59/433 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   373 VKTVGVLGAGLMG---------AGIVQVSVDKGYQVVMKDATEAGLARGIGQVQKGLETAVKR-- 426
            |.:|.::|.|.||         |||....|.:..| ..|...|...||         |.:.||
Worm    39 VNSVAIIGGGTMGKAMAICFGLAGIETFLVVRNEQ-RCKQELEVMYAR---------EKSFKRLN 93

  Fly   427 -KRISALERDQTLASLRPTLDYSDFKNADIIIEAVFEDIKVKHRVIKELEAVVPEHCVIATNTSA 490
             |||..:.     |:|:.|.|:....|.|:|:|:|.||:|:|..:...||.:....|:..||||:
Worm    94 DKRIEKIN-----ANLKITSDFHKLSNCDLIVESVIEDMKLKKELFANLENICKSTCIFGTNTSS 153

  Fly   491 IPITKIAAGSSRPEKVVGMHYFSPVDKMQLLEIITHPGTSKDTIAQAVAVGLKQGKVVITVGDGP 555
            :.:.:|::....|..:||:|:|:|.:.::|:|||....||...||.|........|:.:.||:..
Worm   154 LDLNEISSVLRDPSNLVGIHFFNPANVIRLVEIIYGSHTSSQAIATAFQACESIKKLPVLVGNCK 218

  Fly   556 GFYTTRILSTMLSEAIRLLQE-GVDPKDLDQYTKKFGFPVGAATLADEVGIDVGSHIAVDLAKAF 619
            .|...|:|.....::.:|:.| |..|..:|:....|||.:|..|:||..|.||...:..:
Worm   219 SFVFNRLLHVYFDQSQKLMYEYGYLPHQIDKIITNFGFLMGPMTVADMNGFDVMEKLKKE----- 278

  Fly   620 GERFSGGNLE---VMNDLVLAGFLGRKSGKGIFLYDGQKRGTRPVNNDALEIVKQKYALVSKGAN 681
                  ..||   :..::......|||:.||.:.||.:.:  |..|:..:|.:.::   ||:.|.
Worm   279 ------NGLEPNPIEKEMWRLKRYGRKTNKGFYKYDDKTQ--RKENDTEMEQIIRR---VSQNAK 332

  Fly   682 A------PEDLTLRMVSRFINEAVLCLEEKILDSPLEGDVGAVFGLGFPPFSGGPFRWVDQYGAG 740
            :      .:|:...|:...:||...|:||.::.:....|:..:.|.|:|..||||.|:....|..
Worm   333 SNIQIINDQDVINFMLYPTVNEGYRCIEEGVISNESLIDIMFILGFGWPIHSGGPMRFGKTEGLD 397

  Fly   741 KLVSKMQSYAELYGAPFKPAQTLLDMAKDPSKKFYPKTGSSKL 783
            |:.:.:..::.|  .|.:.|..:.|..|..:.|..    ||||
Worm   398 KIANMLVHWSSL--EPKESAYIVADALKTANNKLM----SSKL 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mtpalpha	NP_609299.1	fa_ox_alpha_mit	38..775	CDD:131494	117/423 (28%)
		crotonase-like	52..235	CDD:119339
		3HCDH_N	375..553	CDD:280833	58/189 (31%)
		3HCDH	556..651	CDD:279114	25/98 (26%)
		3HCDH	689..768	CDD:279114	21/78 (27%)
ech-9	NP_501875.2	FadB	38..317	CDD:224170	88/305 (29%)
		3HCDH_N	41..217	CDD:280833	59/190 (31%)
		3HCDH	220..307	CDD:279114	25/97 (26%)
		3HCDH	343..>397	CDD:279114	16/53 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D134602at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820