DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mtpalpha and Ehhadh

DIOPT Version :9

Sequence 1:	NP_609299.1	Gene:	Mtpalpha / 34276	FlyBaseID:	FBgn0028479	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_598290.1	Gene:	Ehhadh / 171142	RGDID:	621441	Length:	722	Species:	Rattus norvegicus

Alignment Length:	747	Identity:	232/747 - (31%)
Similarity:	365/747 - (48%)	Gaps:	119/747 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 HTKVVNGVLVIKIDSPNAKVNSLGSEVSDEFERVIKDLETNPAVNSAVLISGKPGCFVAGADIGM 117
            :.::.:.:.:|::.:|  .||::...|..|....::...::..| .|::|.|..|.|.|||||
  Rat     4 YLRLPHSLAMIRLCNP--PVNAVSPTVIREVRNGLQKAGSDHTV-KAIVICGANGNFCAGADI-- 63

  Fly   118 LEACQTAEEATLISHGAQV---------MFDRMERSKKPIVAAISGVCLGGGLELALACHYRIAT 173
                          ||...         :.|.::|.:||::|||.||.|||||||||.||||||
  Rat    64 --------------HGFSAFTPGLALGSLVDEIQRYQKPVLAAIQGVALGGGLELALGCHYRIA- 113

  Fly   174 KDSKTKLGLPEVMLGLLPGGGGTVRLPKLTSVPTALDMELTGKQVRADRAKRLGIVDLLV--DPL 236
             ::|.::|||||.||:|||..||..||::..||.|||:..:||.:.||.|.||||:|.:|  ||:
  Rat   114 -NAKARVGLPEVTLGILPGARGTQLLPRVVGVPVALDLITSGKYLSADEALRLGILDAVVKSDPV 177

  Fly   237 GPGLQPAEQNTIEYLEKTAVQVANDLASGKLRVNREKSGLVSKIQSFVMDTDFVKNKIFDTARKQ 301
                            :.|::.|..:....:...|    :.:|....:.:.|.|..:.....|||
  Rat   178 ----------------EEAIKFAQKIIDKPIEPRR----IFNKPVPSLPNMDSVFAEAIAKVRKQ 222

  Fly   302 VLKASNGLYP---APLKILDVIRAGVDKGTDAGYEAERKGFGELSATPESKGL-IALFRGQTECK 362
                    ||   ||...:..|:|.|....:.|.:.|.|.|..|.|:.::|.| .|.|   .|..
  Rat   223 --------YPGVLAPETCVRSIQASVKHPYEVGIKEEEKLFMYLRASGQAKALQYAFF---AEKS 276

  Fly   363 KNRFGKPE---------RPVKTVGVLGAGLMGAGIVQVSVDKGYQVVMKDATEAGLARGIGQVQK 418
            .|::..|.         :||.:|||||.|.||.||.......|..||   |.|:. .:.:...:|
  Rat   277 ANKWSTPSGASWKTASAQPVSSVGVLGLGTMGRGIAISFARVGISVV---AVESD-PKQLDAAKK 337

  Fly   419 GLETAVKRKRISALERDQTLASLRPTLDYS----DFKNADIIIEAVFEDIKVKHRVIKELEAVVP 479
            .:...::::...|.:..|  ||.:|.|.:|    :....|:::||||||:.:|.:|..||.|:..
  Rat   338 IITFTLEKEASRAHQNGQ--ASAKPKLRFSSSTKELSTVDLVVEAVFEDMNLKKKVFAELSALCK 400

  Fly   480 EHCVIATNTSAIPITKIAAGSSRPEKVVGMHYFSPVDKMQLLEIITHPGTSKDTIAQAVAVGLKQ 544
            ....:.|||||:.:..||:.:.||:.|:|.|:|||...|:|||:|....:|..|||..:::..|.
  Rat   401 PGAFLCTNTSALNVDDIASSTDRPQLVIGTHFFSPAHVMRLLEVIPSRYSSPTTIATVMSLSKKI 465

  Fly   545 GKVVITVGDGPGFYTTRILSTMLSEAIRLLQEGVDPKDLDQYTKKFGFPVGAATLADEVGIDVGS 609
            ||:.:.||:..||...|:|:...::...||:||..|:|:|...::|||.:|...::|..|:|||.
  Rat   466 GKIGVVVGNCYGFVGNRMLAPYYNQGFFLLEEGSKPEDVDGVLEEFGFKMGPFRVSDLAGLDVGW 530

  Fly   610 HIAVDLAKAFGERFSGGNL--------------EVMNDLVL-AGFLGRKSGKGIFLYD---GQKR 656
            .|..      |:..:|.:|              ..:.|::. ||..|:|:|||.:.||   |:..
  Rat   531 KIRK------GQGLTGPSLPPGTPVRKRGNSRYSPLGDMLCEAGRFGQKTGKGWYQYDKPLGRIH 589

  Fly   657 GTRPVNNDALEIVKQKYAL----VSKGANAPEDLTLRMVSRFINEAVLCLEEKILDSPLEGDVGA 717
            ...|..:..|...::.:.:    :||     |::..|.:...||||...|||.:...|...||..
  Rat   590 KPDPWLSTFLSQYREVHHIEQRTISK-----EEILERCLYSLINEAFRILEEGMAARPEHIDVIY 649

  Fly   718 VFGLGFPPFSGGPFRWVDQYGAGKLVSKMQSY 749
            :.|.|:|...|||..:....|...::.|:|.|
  Rat   650 LHGYGWPRHKGGPMFYAASVGLPTVLEKLQKY 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mtpalpha	NP_609299.1	fa_ox_alpha_mit	38..775	CDD:131494	232/747 (31%)
		crotonase-like	52..235	CDD:119339	74/192 (39%)
		3HCDH_N	375..553	CDD:280833	63/181 (35%)
		3HCDH	556..651	CDD:279114	32/109 (29%)
		3HCDH	689..768	CDD:279114	21/61 (34%)
Ehhadh	NP_598290.1	Enoyl-CoA hydratase / isomerase	1..281		104/328 (32%)
		crotonase-like	12..187	CDD:119339	78/211 (37%)
		fadJ	20..706	CDD:236864	230/729 (32%)
		3-hydroxyacyl-CoA dehydrogenase	282..571		94/300 (31%)
		3HCDH_N	298..475	CDD:280833	64/182 (35%)
		3HCDH	477..581	CDD:279114	32/109 (29%)
		3HCDH	618..704	CDD:279114	21/64 (33%)
		Microbody targeting signal	720..722
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D134602at33208
OrthoFinder	1	1.000	-	-		FOG0001577
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101291
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1128
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.720