DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mtpalpha and ECI2

DIOPT Version :9

Sequence 1:	NP_609299.1	Gene:	Mtpalpha / 34276	FlyBaseID:	FBgn0028479	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_996667.2	Gene:	ECI2 / 10455	HGNCID:	14601	Length:	394	Species:	Homo sapiens

Alignment Length:	283	Identity:	61/283 - (21%)
Similarity:	113/283 - (39%)	Gaps:	47/283 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SAVGQISRQQLLQN------KCTRALPISAQLLQRRRLMSTNPAPVANKHLHTKVV---NGVLVI 63
            :|:|.:.::...||      ..:.:|..|:|:.......||.        ..|.||   :|:..|
Human    97 NALGSLPKEAARQNYVDLVSSLSPSLESSSQVEPGTDRKSTG--------FETLVVTSEDGITKI 153

  Fly    64 KIDSPNAKVNSLGSEVSDEFERVIKDLETNPAVNSAVLISGKPGCFVAGADI--------GMLEA 120
            ..:.|..| |::.:|:..|..|.:|....:.::  ..:::|....:.:|.|:        |.:|.
Human   154 MFNRPKKK-NAINTEMYHEIMRALKAASKDDSI--ITVLTGNGDYYSSGNDLTNFTDIPPGGVEE 215

  Fly   121 CQTAEEATLISHGAQVMFDRMERSKKPIVAAISGVCLGGGLELALACHYRIATKDSKTKLGLPEV 185
             :....|.|:........|    ..||::|.::|..:|..:.| |.....:...|..| ...|..
Human   216 -KAKNNAVLLREFVGCFID----FPKPLIAVVNGPAVGISVTL-LGLFDAVYASDRAT-FHTPFS 273

  Fly   186 MLGLLPGGGGTVRLPKLTSVPTALDMELTGKQVRADRAKRLGIV-DLLVDPLGPGLQPAEQNTIE 249
            .||..|.|..:...||:.|...|.:|.:.||::.|..|...|:| ::..|           :|.:
Human   274 HLGQSPEGCSSYTFPKIMSPAKATEMLIFGKKLTAGEACAQGLVTEVFPD-----------STFQ 327

  Fly   250 YLEKTAVQVANDLASGKLRVNRE 272
            ....|.::....|....||:::|
Human   328 KEVWTRLKAFAKLPPNALRISKE 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mtpalpha	NP_609299.1	fa_ox_alpha_mit	38..775	CDD:131494	54/247 (22%)
		crotonase-like	52..235	CDD:119339	45/194 (23%)
		3HCDH_N	375..553	CDD:280833
		3HCDH	556..651	CDD:279114
		3HCDH	689..768	CDD:279114
ECI2	NP_996667.2	ACBP	40..113	CDD:279259	4/15 (27%)
		Acyl-CoA binding. /evidence=ECO:0000250	66..70
		crotonase-like	142..335	CDD:119339	47/213 (22%)
		ECH-like	151..322		41/180 (23%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q05871	198..202		1/3 (33%)
		Microbody targeting signal. /evidence=ECO:0000255	392..394
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810