DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment brwl and madf-4

DIOPT Version :9

Sequence 1:	NP_609298.1	Gene:	brwl / 34275	FlyBaseID:	FBgn0032130	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_505565.3	Gene:	madf-4 / 179386	WormBaseID:	WBGene00011575	Length:	329	Species:	Caenorhabditis elegans

Alignment Length:	233	Identity:	48/233 - (20%)
Similarity:	100/233 - (42%)	Gaps:	40/233 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 DEDFNIRFVNLVRTHKCLYDKKVPEYRNRDNQEKAWVLISKET--RESVIHCKERWRNLRACLSR 116
            ::||.:..::.|:.:.|:|::..|.::..|.:.:.|.|||.|.  ....:..:.:|:::|   .:
Worm    15 EDDFTLALIDSVQRNPCVYNRYDPLHKVTDYKHEIWKLISIEIGYDGQPVELERKWKHMR---DK 76

  Fly   117 YI------KQQSGSEPQHKPYYLTEHMAFLLPFL-----KSSRNSLEGN------NSLATLYQMS 164
            |:      ||::..:..:|.|.....|:||.|::     |..::.|..|      :..|.|..:|
Worm    77 YVRLRKQDKQKAPIKKTNKWYNYYHKMSFLDPYVEHRNRKRQKDYLNSNTPDFLDDDTAFLDGLS 141

  Fly   165 -QQHLQHQPFLLHPALHATEEHKYCANTSINNNNNNN-------DVHNGESMEVLEMKYSISEKD 221
             ::.|:.:..|..........|...:::|..:|||..       |:.:.:....|.....::.:.
Worm   142 VKEMLKPESLLTSNDAGYNSPHTTSSSSSSGSNNNGRFLDSPTIDIEDDKKNLALIYDKFVANQT 206

  Fly   222 DEETIDAFDP--------AVTNTL--GMNRTSSTPTRS 249
            :.|....|..        :.||||  .:..||:.|:.|
Worm   207 ENEKNHRFSNKHGKDLLFSTTNTLIEKLATTSTAPSSS 244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brwl	NP_609298.1	MADF	60..145	CDD:214738	21/97 (22%)
brwl	NP_609298.1	BESS	356..389	CDD:281011
madf-4	NP_505565.3	MADF	22..111	CDD:214738	21/91 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001895
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12243
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010