DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp30B and Slco1a6

DIOPT Version :9

Sequence 1:	NP_609293.2	Gene:	Oatp30B / 34268	FlyBaseID:	FBgn0032123	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_570092.1	Gene:	Slco1a6 / 84608	RGDID:	69304	Length:	670	Species:	Rattus norvegicus

Alignment Length:	716	Identity:	223/716 - (31%)
Similarity:	347/716 - (48%)	Gaps:	139/716 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 EEQFRSGDCGILNCRPYGIQRFARIKIFVVLLSLLVMMQQALSSGYINSVITTIEKRFEIPSSYS 209
            |.:.|:|        .:||:.||:||:|::.|: .....:|||:.|:||::|.||:||.|.:|..
  Rat     3 EPEKRAG--------THGIRCFAKIKVFLLALT-WAYASKALSATYMNSMLTQIERRFNISTSIV 58

  Fly   210 GLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIMGIGSLVFMVPHFTGEPNPGIAIVNKTS 274
            |||..|:|:||::.:|||||.|.:||.|:.||||..:||:|..:..:|||.
  Rat    59 GLINGSFEVGNLLLIIFVSYFGRKRHRPIMIGIGCAVMGLGCFIISLPHFL-------------- 109

  Fly   275 DNICKSALVRDQDMDLGRLSSGLSNQPLAPHTLREDNCLEGKASTTGP--------------VLL 325
                           :||.....:..|.:..:.....|:|.:..|..|              :.:
  Rat   110 ---------------MGRYEYETTISPTSNLSSNSFLCMENRTQTLKPTQDPAECVKEMKSLMWI 159

  Fly   326 FVL-AQLLLGCGGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMD- 388
            :|| ..::.|.|.:|:..||.:|::|..::|:|..|||.:......||:....||::..:.::|
  Rat   160 YVLVGNIIRGIGETPIMPLGISYIEDFAKSENSPFYIGILEVGKITGPIAAIWLGSFCATIYVDM 224

  Fly   389 -SLSSTTISITPGDRRWVGMWWGGFLLCGVILLVVAVPFFSFPKVLAREKKKIRKSSVVQPVLPN 452
             |:::..::|||.|.|.||.||.|||:|..:.:::::|||.|||...:|.             |.
  Rat   225 GSVNTDDLTITPTDTRCVGAWWIGFLVCAGLNILISIPFFFFPKTFPKEG-------------PE 276

  Fly   453 NSRATVATDEMGKVKKLEIVAVTSKEDQSQAPPKVDTGYGKDIKDIPQSMLRLVKNPVYIVTCLG 517
            :.......||..|.::      .:||::...           .||....|..|..||:|::..|.
  Rat   277 DMANETKNDEGDKHRE------KAKEEKRGI-----------TKDFFLFMKSLSCNPIYMLCVLT 324

  Fly   518 ACMELMIVSGFV---VFLPKYLETQFSLGKSQANIFTGSIAVPGACIGIFLGGCILKRFQLKPKG 579
            :.::   |:|||   .|.|||||..:....|:|....|...:|..|:|..:.|.|:|:|::..|.
  Rat   325 SVLQ---VNGFVSIFTFKPKYLEHHYGKSSSEAIFLMGLYTLPSVCVGYLISGFIMKKFKITLKK 386

  Fly   580 AVQFVLITNVICLA---CYAML--FFLGCDNLKMAGTTIPYYTSNKHGSTLEQPFQVNLT--AAC 637
            |. |:    ..||.   |...|  |.|.|||:.:||.|..|       ..::|.|.:..|  |.|
  Rat   387 AA-FI----SYCLGMSECLLSLCNFMLTCDNVPIAGLTTSY-------EGIQQSFDMENTVLADC 439

  Fly   638 NFGCECLTSEVEPVCGNNGLTYFSPCHAGC-TAFSSTSNTNYTNCACVRANISSSIYRGAGGSQA 701
            |..|.|||...:||||:|||.|.:||.||| .:..|..|....:|:|::::.:||
  Rat   440 NTRCSCLTKTWDPVCGDNGLAYITPCLAGCEKSVGSGINMVLQDCSCIQSSGNSS---------- 494

  Fly   702 QALSANENFAEVTVVPVATAGP-CATPCRTIYPFLILLFFMTFLVASTQMPLLMIVLRSVSEEER 765
                        .|:.:...|| ||   ..:..|||:..|.:|..:.:.:|..||.||.:..||:
  Rat   495 ------------AVLGLCNKGPDCA---NKLQYFLIITVFCSFFYSLSLIPGYMIFLRCMKSEEK 544

  Fly   766 SFALGMQFVIFRLFGYIPAPILFGNLIDSTCILW-KSSCGEKGGRCLIYDIEKFRYKYVGLCASV 829
            |..:|:|....|:.|.|.|||.||.|||.||:.| ...|||.|. |..|:|..||..|:||.|::
  Rat   545 SLGIGLQAFCMRILGGILAPIYFGVLIDRTCLHWGTQKCGEPGA-CRTYEINSFRSIYLGLPAAL 608

  Fly   830 K 830
            :
  Rat   609 R 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp30B	NP_609293.2	OATP	171..818	CDD:281175	208/676 (31%)
		MFS	174..>433	CDD:119392	86/275 (31%)
		MFS	512..>600	CDD:304372	28/95 (29%)
		KAZAL_SLC21	633..684	CDD:238650	24/53 (45%)
Slco1a6	NP_570092.1	oat	1..625	CDD:273279	223/716 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	276..295		3/24 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	647..670
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X98
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810