DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp30B and SLCO5A1

DIOPT Version :9

Sequence 1:	NP_609293.2	Gene:	Oatp30B / 34268	FlyBaseID:	FBgn0032123	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_112220.2	Gene:	SLCO5A1 / 81796	HGNCID:	19046	Length:	848	Species:	Homo sapiens

Alignment Length:	793	Identity:	284/793 - (35%)
Similarity:	432/793 - (54%)	Gaps:	86/793 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 AGDQLPSTVGSGPGGG------GPSAVADSVTVKCHSRQASAGKCPADPEEDFDEEQFRSGDCGI 155
            :||..|: .|.....|      ||:.:|.|.:..  |..|..|.|  :...|..:....|....:
Human    54 SGDANPA-FGCVDSSGHQELKQGPNPLAPSPSAP--STSAGLGDC--NHRVDLSKTFSVSSALAM 113

  Fly   156 LNCRPYGIQRFARIKIFVVLLSLLVMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGN 220
            |..|..........:.|:|.:..|..:|..:.|||::|||||||:|:.:.||.|||:.|.::|||
Human   114 LQERRCLYVVLTDSRCFLVCMCFLTFIQALMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGN 178

  Fly   221 VITVIFVSYLGSRRHIPVWIGIGAVIMGIGSLVFMVPHFTGEPNPGIAIVNKT--SDNICKSALV 283
            ::.|:||||.|.|...|:|:.:|.:::..|:.:|.:|||...|.. |..:|.:  :|.:|:
Human   179 LVVVVFVSYFGGRGRRPLWLAVGGLLIAFGAALFALPHFISPPYQ-IQELNASAPNDGLCQ---- 238

  Fly   284 RDQDMDLGRLSSGLSNQPLAPHTLREDNCLEGKASTTGPVLLFVLAQLLLGCGGSPLFTLGTTYV 348
                       .|.|...|.|....:|:   |..:....|.||:.||:|:|.|.:|::|||.||:
Human   239 -----------GGNSTATLEPPACPKDS---GGNNHWVYVALFICAQILIGMGSTPIYTLGPTYL 289

  Fly   349 DDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMDSLSSTTISITPGDRRWVGMWWGGFL 413
            ||:|:.|:||:|:..||.|||.||.||:|||..|:.|::|  ....:.:...|.|::|.||.|||
Human   290 DDNVKKENSSLYLAIMYVMGALGPAVGYLLGGLLIGFYVD--PRNPVHLDQNDPRFIGNWWSGFL 352

  Fly   414 LCGVILLVVAVPFFSFPKVL-AREKKKIRKSSVVQPVLPNNSRATVATDEMGKVKKLEIVAVTSK 477
            ||.:.:.:|..|.|:|||.| .|.|||.:|...|.         .|:.|::.|.|         .
Human   353 LCAIAMFLVIFPMFTFPKKLPPRHKKKKKKKFSVD---------AVSDDDVLKEK---------S 399

  Fly   478 EDQSQAPPKVDT-GYGKDIKDIPQSMLRLVKNPVYIVTCLGACMELMIVSGFVVFLPKYLETQFS 541
            .:..||..||.: |:|||::|:|::.:|::.|..::...|....|..||:.|:.|:||::|:||.
Human   400 NNSEQADKKVSSMGFGKDVRDLPRAAVRILSNMTFLFVSLSYTAESAIVTAFITFIPKFIESQFG 464

  Fly   542 LGKSQANIFTGSIAVPGACIGIFLGGCILKRFQLKPKGAVQFVLITNVICLACYAMLFFLGCDNL 606
            :..|.|:|:||.|.||.|.:||.|||.|:|:.:|..:.:.:..:|.:.:.|.|::.||.:||:::
Human   465 IPASNASIYTGVIIVPSAGVGIVLGGYIIKKLKLGARESAKLAMICSGVSLLCFSTLFIVGCESI 529

  Fly   607 KMAGTTIPYYTSNKHGSTLEQPFQVNLTAACNFGCECLTSEVEPVCGNNGLTYFSPCHAGC--TA 669
            .:.|..|||.|    |.:|..|.: |||.:||..|.|...|.|||||::|:|||:||.|||  :.
Human   530 NLGGINIPYTT----GPSLTMPHR-NLTGSCNVNCGCKIHEYEPVCGSDGITYFNPCLAGCVNSG 589

  Fly   670 FSSTSNTNYTNCACVRANISSSIYRGAGGSQAQ------ALSANENFAEVTVVPVATAGPCATPC 728
            ..||...|||.|.||::.  ..|.....|.::|      ....|||       ..|.:|.|...|
Human   590 NLSTGIRNYTECTCVQSR--QVITPPTVGQRSQLRVVIVKTYLNEN-------GYAVSGKCKRTC 645

  Fly   729 RTIYPFLILLFFMTFLVASTQMPLLMIVLRSVSEEERSFALGMQFVIFRLFGYIPAPILFGNLID 793
            .|:.|||:.||.:||:.|..|...:::.||||.:|||.||||||||:.|...|||.||.||.:||
Human   646 NTLIPFLVFLFIVTFITACAQPSAIIVTLRSVEDEERPFALGMQFVLLRTLAYIPTPIYFGAVID 710

  Fly   794 STCILWKSSCGEKGGRCLIYDIEKFRYKYVGLCASVKLIALVIFMVDWWLVR-------RRKQLE 851
            :||:||:..||.:|. |..|::..||:.|.||.|.:|.:..:...:.|:.::       ||:|.|
Human   711 TTCMLWQQECGVQGS-CWEYNVTSFRFVYFGLAAGLKFVGFIFIFLAWYSIKYKEDGLQRRRQRE 774

  Fly   852 KMKPLNASDPIIG 864
              .||:.....:|
Human   775 --FPLSTVSERVG 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp30B	NP_609293.2	OATP	171..818	CDD:281175	252/658 (38%)
		MFS	174..>433	CDD:119392	101/260 (39%)
		MFS	512..>600	CDD:304372	32/87 (37%)
		KAZAL_SLC21	633..684	CDD:238650	27/52 (52%)
SLCO5A1	NP_112220.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..91		10/39 (26%)
		OATP	129..734	CDD:281175	252/658 (38%)
		MFS	131..>531	CDD:119392	159/438 (36%)
		KAZAL_SLC21	551..605	CDD:238650	28/53 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	821..848
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145457
Domainoid	1	1.000	465	1.000	Domainoid score	I472
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H57135
Inparanoid	1	1.050	485	1.000	Inparanoid score	I1447
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123298at33208
OrthoFinder	1	1.000	-	-		FOG0007263
OrthoInspector	1	1.000	-	-		oto90883
orthoMCL	1	0.900	-	-		OOG6_101062
Panther	1	1.100	-	-	LDO	PTHR11388
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X98
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.800