DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp30B and Slco1a3

DIOPT Version :9

Sequence 1:	NP_609293.2	Gene:	Oatp30B / 34268	FlyBaseID:	FBgn0032123	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_110464.2	Gene:	Slco1a3 / 80899	RGDID:	621387	Length:	670	Species:	Rattus norvegicus

Alignment Length:	710	Identity:	219/710 - (30%)
Similarity:	352/710 - (49%)	Gaps:	129/710 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 YGIQRFARIKIFVVLLSLLVMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVI 225
            :|...||:||:|::.|: ...:.::||..:::|::|.||::|.||::..|.|..|:||||::.:|
  Rat    11 HGAGCFAKIKVFLMALT-CAYVSKSLSGTFMSSMLTQIERQFGIPTAIVGFINGSFEIGNLLLII 74

  Fly   226 FVSYLGSRRHIPVWIGIGAVIMGIGSLVFMVPHFTGEPNPGIAIVNKTSDNICKSALVRDQDMDL 290
            ||||.|.:.|.|:.||:|..:||:|..:..:|||.                             :
  Rat    75 FVSYFGMKLHRPIVIGVGCAVMGLGCFIISLPHFL-----------------------------M 110

  Fly   291 GRLSSGLSNQPLAPHTLREDNCLEGKASTTGP--------------VLLFVL-AQLLLGCGGSPL 340
            ||.....:..|.:..:.....|:|.:..|..|              :.::|| ..::.|.|.:|:
  Rat   111 GRYEYETTILPTSNLSSNSFLCMENQTQTLNPAQDPAECVKEVKSLMWIYVLVGNIIRGIGETPI 175

  Fly   341 FTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMD--SLSSTTISITPGDRR 403
            ..||.:|:::..::|:|.:|||.:.:....||:.|.|||::..|.::|  |:::..::|||.|.|
  Rat   176 MPLGVSYIENFAKSENSPLYIGILETGKMIGPIFGLLLGSFCASIYVDTGSVNTDDLTITPTDIR 240

  Fly   404 WVGMWWGGFLLCGVILLVVAVPFFSFPKVLAREKKKIRKSSVVQPVLPNNSRATV-ATDEMGKVK 467
            |||.||.|||:|..:.:::::|||.|||.|.:|.            |..|...|. |.:|..:.|
  Rat   241 WVGAWWIGFLVCAGVNILISIPFFFFPKTLPKEG------------LQENVDGTENAKEEKHREK 293

  Fly   468 KLEIVAVTSKEDQSQAPPKVDTGYGKDIKDIPQSMLRLVKNPVYIVTCLGACMELMIVSGFVVFL 532
                    :||::        .|..||.....:|   |..||:|::..|.:.:::...:.:..||
  Rat   294 --------AKEEK--------RGITKDFFPFLKS---LSCNPIYMLFTLISVLQVNAFNIYFSFL 339

  Fly   533 PKYLETQFSLGKSQANI--FTGSIAVPGACIGIFLGGCILKRFQLKPKGAVQFVLITNVICLACY 595
            |||||.|:  |||.|.:  ..|...:|..|||..:.|.::|:|::..|.|   ..:...:.|:.|
  Rat   340 PKYLENQY--GKSTAEVIFLMGVYNLPAICIGYLIAGFMMKKFKITVKTA---AFLAFCLSLSEY 399

  Fly   596 AM---LFFLGCDNLKMAGTTIPYYTSNKHGSTLEQPFQV--NLTAACNFGCECLTSEVEPVCGNN 655
            :.   .|.:.|||:.:||.|..|....|       |..:  |:.|.||..|.|||...:||||:|
  Rat   400 SFGFCNFLITCDNVPVAGLTNSYERDQK-------PLYLENNVLADCNTRCSCLTKTWDPVCGDN 457

  Fly   656 GLTYFSPCHAGCTAFSST-SNTNYTNCACVRANISSSIYRGAGGSQAQALSANENFAEVTVVPVA 719
            ||.|.|.|.|||.....| :|..:.||:|:::         .|.|.|             |:.:.
  Rat   458 GLAYMSACLAGCEKSVGTGTNMVFHNCSCIQS---------PGNSSA-------------VLGLC 500

  Fly   720 TAGPCATPCRTIYPFLILLFFMTFLVASTQMPLLMIVLRSVSEEERSFALGMQFVIFRLFGYIPA 784
            ..||..|  ..:...|||..|::.|.:...:|..|:.||.:..||:|..:|:.....|:|..|||
  Rat   501 NKGPECT--NKLQYLLILSGFLSILYSFAAIPGYMVFLRCIKSEEKSLGIGIHAFCIRVFAGIPA 563

  Fly   785 PILFGNLIDSTCILW-KSSCGEKGGRCLIYDIEKFRYKYVGLCASVK----LIALVIFMV 839
            ||.||.|||.||:.| ...||..|. |.:|||..||..|:|:.|:::    |.|.||.::
  Rat   564 PIYFGALIDRTCLHWGTQKCGAPGA-CRMYDINSFRRIYLGMSAALRGSSYLPAFVIVIL 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp30B	NP_609293.2	OATP	171..818	CDD:281175	205/673 (30%)
		MFS	174..>433	CDD:119392	83/275 (30%)
		MFS	512..>600	CDD:304372	25/92 (27%)
		KAZAL_SLC21	633..684	CDD:238650	24/51 (47%)
Slco1a3	NP_110464.2	oat	1..625	CDD:273279	219/710 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X98
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810