DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp30B and slco2b1

DIOPT Version :9

Sequence 1:	NP_609293.2	Gene:	Oatp30B / 34268	FlyBaseID:	FBgn0032123	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_001032767.2	Gene:	slco2b1 / 792084	ZFINID:	ZDB-GENE-051023-6	Length:	677	Species:	Danio rerio

Alignment Length:	700	Identity:	215/700 - (30%)
Similarity:	354/700 - (50%)	Gaps:	109/700 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 RPYGIQRFARIKIFVVLLSLLVMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVIT 223
            |..|:  |..||.||:...:| .:.|.|.|||:.:.|||||||:...||.|||:|:..|:||.:.
Zfish    17 RSMGL--FNNIKFFVLCHGML-QLSQLLVSGYLKASITTIEKRYGFSSSKSGLLAAFNEVGNTVL 78

  Fly   224 VIFVSYLGSRRHIPVWIGIGAVIMGIGSLVFMVPHFTGEPNPGIAIVNKTSDNICKSALVRDQDM 288
            ::|||:.|||.|.|..||||.:|..:|..:..:|||..|.......::.|..|   |:|.:.||:
Zfish    79 IVFVSFFGSRVHRPRCIGIGGMIASMGVFLIALPHFISEKYEYTEFISNTRLN---SSLCQTQDI 140

  Fly   289 DLGRLSSGLSNQPLAPHTLREDNCLEGKASTTGPVL----LFVLAQLLLGCGGSPLFTLGTTYVD 349
            :    ||...:|                 :.|.|.|    :.:|.|||||.||.|:...|.:|:|
Zfish   141 E----SSPTCSQ-----------------NDTDPQLGVYPILLLGQLLLGIGGVPIQPFGISYID 184

  Fly   350 DHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFH--MDSLSSTTISITPGDRRWVGMWWGGF 412
            |:....:|..|:|.::::...||..|:::.:.:|..:  :|.:|.....:..||.||:|.||.||
Zfish   185 DYAERRNSPFYLGILFAVTVIGPAFGYIMSSAVLRLYVDIDKMSLNENKLEHGDPRWIGAWWLGF 249

  Fly   413 LLCGVILLVVAVPFFSFPKVLAREKKKIRKSSVVQPVLPNNSRATVATDEMGKVKKLEIVAVTSK 477
            |:...:|.:.::|:..||:.:::|  :|.::    ||.|       :|::|.:.||.|
Zfish   250 LIAATLLSLTSLPYLFFPRKMSKE--EIEEA----PVEP-------STEKMIQNKKPE------- 294

  Fly   478 EDQSQAPPKVDTGYGKDIKDIPQSMLRLVKNPVYIVTCLGACMELMIVSGFVVFLPKYLETQFSL 542
            .||.:     :....:.:|..|..:||.::||:|::..........:|:|...|:.|::|.||:.
Zfish   295 TDQIE-----EVSLTQFLKSFPTIVLRTLRNPIYLLVVFAQVNLAAMVAGLATFMGKFIEKQFAR 354

  Fly   543 GKSQANIFTGSIAVPGACIGIFLGGCILKRFQLKPKGAVQFVLITNVICLACYAMLFFLGCDNLK 607
            ..|.:||..|.|.:|.|..||..||.||:|..|..:.:.....|...|.:.....|.|:||...|
Zfish   355 TASFSNIMMGGINIPSAMFGIMAGGVILRRLGLTVRSSAAMCTIAVFISIMFAIPLLFIGCPTQK 419

  Fly   608 MAGTTIPYYTSNKHGSTLEQPFQVNLTAACNFGCECLTSEVEPVCGNNGLTYFSPCHAGC----- 667
            ::|  :.|..|.:                |:..|.|......||||::|:.:.|||||||
Zfish   420 ISG--LNYRDSQQ----------------CSNSCYCSDEAFNPVCGSDGVEFRSPCHAGCKIVNI 466

  Fly   668 TAFSSTSNTNYTNCACVRANISSSIYRGAGGSQAQALSANENFAEVTVVPVATAGPCATPC-RTI 731
            .......|..||:|.||:::       |:.|                   .|.|||||:.| ..:
Zfish   467 KTIGRIQNVTYTDCGCVKSS-------GSPG-------------------FAFAGPCASGCSNLL 505

  Fly   732 YPFLILLFFMTFLVASTQMPLLMIVLRSVSEEERSFALGMQFVIFRLFGYIPAPILFGNLIDSTC 796
            .||:||.....|:.:.:.....|::||:|:.|::|||:|:||::||:..::|:|:|:|..||:.|
Zfish   506 IPFMILSSLTCFVASLSHTTSFMMILRTVTPEDKSFAVGIQFMLFRVLAFLPSPVLYGTAIDTAC 570

  Fly   797 ILWKSSCGEKGGRCLIYDIEKFRYKYVGLCASVKLIALVIFMVDWWLVRR 846
            ::|...| .|...||.|:::.||::::||.........|.|::.:.::||
Zfish   571 LVWGKKC-SKSTSCLYYNLDLFRHRFLGLQIFFICGGFVCFLLSFLVLRR 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp30B	NP_609293.2	OATP	171..818	CDD:281175	202/658 (31%)
		MFS	174..>433	CDD:119392	88/264 (33%)
		MFS	512..>600	CDD:304372	25/87 (29%)
		KAZAL_SLC21	633..684	CDD:238650	19/55 (35%)
slco2b1	NP_001032767.2	OATP	27..591	CDD:308646	202/658 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X98
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910