Protein Alignment Oatp30B and SLCO1A2

DIOPT Version :10

• Sequence 1: NP_609293.2
• Gene: Oatp30B / 34268
• FlyBaseID: FBgn0032123
• Length: 1197
• Species: Drosophila melanogaster
• Sequence 2: NP_066580.1
• Gene: SLCO1A2 / 6579
• HGNCID: 10956
• Length: 670
• Species: Homo sapiens
• Alignment Length: 743
• Identity: 224/743 - (30%)
• Similarity: 362/743 - (48%)
• Gaps: 131/743 - (17%)

  Fly   163 IQRFARIKIFVVLLSLLVMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFV 227
            |:..:::|:|::.:: ...:.:.||..|:||::|.||::|.||:|..|.|..|:||||::.:|||
Human    13 IRCLSKLKMFLLAIT-CAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFV 76

  Fly   228 SYLGSRRHIPVWIGIGAVIMGIGSLVFMVPHF---TGEPNPGIAIVNKTSDN--ICKSALVRDQD 287
            ||.|::.|.|:.||||.|:||:|..:..:|||   ..|....:::....|.|  :|
Human    77 SYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLMNQYEYESTVSVSGNLSSNSFLC--------- 132

  Fly   288 MDLGRLSSGLSNQPLAPHTLREDNCLEGKASTTGPVLLFV---LAQLLLGCGGSPLFTLGTTYVD 349
            |:.|       .|.|.| |.....|.:...|     |::|   :..::.|.|.:|:..||.:|::
Human   133 MENG-------TQILRP-TQDPSECTKEVKS-----LMWVYVLVGNIVRGMGETPILPLGISYIE 184

  Fly   350 DHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMDS--LSSTTISITPGDRRWVGMWWGGF 412
            |..:.|:|.:|||.:.:....||::|.||.::..:.::|:  :::..:.|||.|.||||.||.||
Human   185 DFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGF 249

  Fly   413 LLCGVILLVVAVPFFSFPKVLAREKKKIRKSSVVQPVLPNNSRATVATDEMGKVKKLEIVAVTSK 477
            |:|..:.::.|:|||..|..|.:|                           |.....:|:...::
Human   250 LICAGVNVLTAIPFFFLPNTLPKE---------------------------GLETNADIIKNENE 287

  Fly   478 EDQSQAPPKVDTGYGKDIKDIPQSMLRLVKNPVYIVTCLGACMELMIVSGFVVFLPKYLETQFSL 542
            :.|.:...|...|..||.....:|   |..||:|::..|.:.::.......:.|:|||||.|:.:
Human   288 DKQKEEVKKEKYGITKDFLPFMKS---LSCNPIYMLFILVSVIQFNAFVNMISFMPKYLEQQYGI 349

  Fly   543 GKSQANIFTGSIAVPGACIGIFLGGCILKRFQLKPKGAVQFVLITNVICLACYAMLFFLGCDNLK 607
            ..|.|....|...:|..|||..:||.|:|:|::..|.|.......:::....|.:.|.:.|:|..
Human   350 SSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSS 414

  Fly   608 MAGTTIPY-------YTSNKHGSTLEQPFQVNLTAACNFGCECLTSEVEPVCGNNGLTYFSPCHA 665
            :.|....|       |..|            ::.|.||..|.|.:...:||||||||:|.|.|.|
Human   415 VVGINTSYEGIPQDLYVEN------------DIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLA 467

  Fly   666 GC-TAFSSTSNTNYTNCACVRANISSSIYRGAGGSQAQALSANENFAEVTVVPVATAGP-CATPC 728
            || |:..:..|..:.||:|::.:.:||                      .|:.:...|| |:.
Human   468 GCETSIGTGINMVFQNCSCIQTSGNSS----------------------AVLGLCDKGPDCSL-- 508

  Fly   729 RTIYPFLILLFFMTFLVASTQMPLLMIVLRSVSEEERSFALGMQFVIFRLFGYIPAPILFGNLID 793
             .:..||||....:|:.:...:|..|::||.:..||:|..:|:.....|:|..|||||.||.|:|
Human   509 -MLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKSEEKSLGVGLHTFCTRVFAGIPAPIYFGALMD 572

  Fly   794 STCILWKS-SCGEKGGRCLIYDIEKFRYKYVGLCASVK----LIALVIFMVDWWLVRRRKQLEKM 853
            |||:.|.: .|||.|. |.|||...|||.|:||.|:::    :.||:|      |:..||.  .:
Human   573 STCLHWGTLKCGESGA-CRIYDSTTFRYIYLGLPAALRGSSFVPALII------LILLRKC--HL 628

  Fly   854 KPLNASDPIIGSIISLDKLFEEKLSGAE 881
            ...|||        |..:|.|.|:.|.|
Human   629 PGENAS--------SGTELIETKVKGKE 648

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp30B	NP_609293.2	MFS_SLCO5_OATP5	170..758	CDD:340962	172/606 (28%)
		UhpC	<730..795	CDD:441872	24/64 (38%)
SLCO1A2	NP_066580.1	oat	1..625	CDD:273279	213/708 (30%)