DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp30B and SLCO2A1

DIOPT Version :9

Sequence 1:	NP_609293.2	Gene:	Oatp30B / 34268	FlyBaseID:	FBgn0032123	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_005621.2	Gene:	SLCO2A1 / 6578	HGNCID:	10955	Length:	643	Species:	Homo sapiens

Alignment Length:	728	Identity:	233/728 - (32%)
Similarity:	353/728 - (48%)	Gaps:	120/728 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 DEEQFRSGDCGILNCRPYGIQRFARIKIFVVLLSLLVMMQQALSSGYINSVITTIEKRFEIPSSY 208
            |....|:|.|        ....|..||:||:...|| .:.|.|.|.|..|.:|||||||.:.||.
Human    14 DTSTSRAGRC--------ARSVFGNIKVFVLCQGLL-QLCQLLYSAYFKSSLTTIEKRFGLSSSS 69

  Fly   209 SGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIMGIGSLVFMVPHFTGEPNPGIAIVNKT 273
            ||||:|..||.|.|.:|||||.|||.|.|..||||.:.:..|:.:..:|||..||..  ..:..|
Human    70 SGLISSLNEISNAILIIFVSYFGSRVHRPRLIGIGGLFLAAGAFILTLPHFLSEPYQ--YTLAST 132

  Fly   274 SDN------ICKSALVRDQDMDLGRLSSGLSNQPLAPHTLREDNCLEGKASTTGPVLLFVLAQLL 332
            .:|      :|:.   ..||:...:..|...|..      :|.:.:.|         |.|:||||
Human   133 GNNSRLQAELCQK---HWQDLPPSKCHSTTQNPQ------KETSSMWG---------LMVVAQLL 179

  Fly   333 LGCGGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMD--SLSSTTI 395
            .|.|..|:...|.:||||.....:|.:||..::::..|||..|:|||:.:|...:|  .:::..:
Human   180 AGIGTVPIQPFGISYVDDFSEPSNSPLYISILFAISVFGPAFGYLLGSVMLQIFVDYGRVNTAAV 244

  Fly   396 SITPGDRRWVGMWWGGFLLCGVILLVVAVPFFSFPKVLAREKKKIRKSSVVQPVLPNNSRATVAT 460
            ::.|||.||:|.||.|.|:...:|::.:.|||.||:.:              |:  ...||....
Human   245 NLVPGDPRWIGAWWLGLLISSALLVLTSFPFFFFPRAM--------------PI--GAKRAPATA 293

  Fly   461 DEMGKVKKLEIVAVTSKEDQSQAPPKVDTGYGKDIKDIPQSMLRLVKNPVYIVTCLGACMELMIV 525
            ||..|:           |:.......||.     ||..|...|||:.|.::::..|..|....::
Human   294 DEARKL-----------EEAKSRGSLVDF-----IKRFPCIFLRLLMNSLFVLVVLAQCTFSSVI 342

  Fly   526 SGFVVFLPKYLETQFSLGKSQANIFTGSIAVPGACIGIFLGGCILKRF----QLKPKGAVQFVLI 586
            :|...||.|:||.|:....:.||...|::.:|.|.:|:..||.::|||    |..|:.|...:.|
Human   343 AGLSTFLNKFLEKQYGTSAAYANFLIGAVNLPAAALGMLFGGILMKRFVFSLQAIPRIATTIITI 407

  Fly   587 TNVICLACYAMLFFLGCDNLKMAGTTIPYYTSNKHGSTLEQPFQVNLTAACNFGCECLTSEVEPV 651
            :.::|:.    |||:||....:|....|..:|:.|..          :.||...|.|..|...||
Human   408 SMILCVP----LFFMGCSTPTVAEVYPPSTSSSIHPQ----------SPACRRDCSCPDSIFHPV 458

  Fly   652 CGNNGLTYFSPCHAGCTAFSSTSNTN----YTNCACVRANISSSIYRGAGGSQAQALSANENFAE 712
            ||:||:.|.|||||||:..:.:|.|:    |.||:||           .|||.:
Human   459 CGDNGIEYLSPCHAGCSNINMSSATSKQLIYLNCSCV-----------TGGSAS----------- 501

  Fly   713 VTVVPVATAGPCATPC-RTIYPFLILLFFMTFLVASTQMPLLMIVLRSVSEEERSFALGMQFVIF 776
                  |..|.|..|| ..:.|.:.|:.|::.:...:..||.|:|||.|::||:|||:|:||::.
Human   502 ------AKTGSCPVPCAHFLLPAIFLISFVSLIACISHNPLYMMVLRVVNQEEKSFAIGVQFLLM 560

  Fly   777 RLFGYIPAPILFGNLIDSTCILWKSSCGEKGGRCLIYDIEKFRYKYVGLCASVKLIALVIFMVDW 841
            ||..::|:|.|:|..||.:||.|.|.|..:.|.|..||.:..|.:|:||....|.:.:::.....
Human   561 RLLAWLPSPALYGLTIDHSCIRWNSLCLGRRGACAYYDNDALRDRYLGLQMGYKALGMLLLCFIS 625

  Fly   842 WLVRRRKQLEKMK 854
            |.|::.|:....|
Human   626 WRVKKNKEYNVQK 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp30B	NP_609293.2	OATP	171..818	CDD:281175	217/663 (33%)
		MFS	174..>433	CDD:119392	96/266 (36%)
		MFS	512..>600	CDD:304372	26/91 (29%)
		KAZAL_SLC21	633..684	CDD:238650	24/54 (44%)
SLCO2A1	NP_005621.2	oat	1..630	CDD:273279	231/718 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X98
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810