DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp30B and Gm7133

DIOPT Version :9

Sequence 1:	NP_609293.2	Gene:	Oatp30B / 34268	FlyBaseID:	FBgn0032123	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	XP_986805.2	Gene:	Gm7133 / 634331	MGIID:	3643070	Length:	696	Species:	Mus musculus

Alignment Length:	724	Identity:	184/724 - (25%)
Similarity:	296/724 - (40%)	Gaps:	133/724 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 ADPEE-DFDEEQFRSGDCGILNCRPYGIQRFARIKIFVVLLSLLVMMQQALSSGYINSVITTIEK 200
            :||.. |..|..|..|.. :.:|    :|||..|:.|:: ...:|::...:....|:..:...|.
Mouse    55 SDPNYCDTSEGPFGFGPL-VFSC----LQRFNTIEFFLI-SCFVVILAHGMMFALIDMSLKIFET 113

  Fly   201 RFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIMGIGSLVFMVPHFTGEPNP 265
            :|:..:..:.|:..|....:.:..|||::.|.|.:...|:..|:::..:.|:.|:|..|..|
Mouse   114 QFQATNLETFLMDFSDYFASFLVSIFVAHFGGRGNRAKWVAAGSIVTALSSIAFIVLFFYYE--- 175

  Fly   266 GIAIVNKTSDNICKSALVRDQDMDLGRLSSGLSNQPLAPHTLREDNCLEGK-----ASTTGP--- 322
                       |.|.|.|                        :||.|.|||     .:|..|
Mouse   176 -----------IIKLAKV------------------------KEDLCDEGKIPKVCGTTLMPNKS 205

  Fly   323 --VLLFVLAQLLLGCGGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSF 385
              :.||::.|.|.|..|..:..|..||:.|||.|.||.:|:....:....|..:|:|||  :.||
Mouse   206 ICIALFIVGQCLHGVAGIIVQLLSITYIFDHVPTFSSGLYLAIADAAITLGYTLGYLLG--VKSF 268

  Fly   386 HMD-SLSSTTISITPGDRRWVGMWWGGFLLCGVILLVVAVPFFSFPKVLAREKKKIRKSSVVQPV 449
            .:. ..:...:......|.....||..|:..|.:.|...:|...||.                 .
Mouse   269 MLPVKEAMQAVGHVQRFRILQSGWWKSFIFVGSLSLCTTLPLLCFPS-----------------N 316

  Fly   450 LPNNSRATVATDEMGKVKKLEIVAVTSKEDQSQAPPKVDTGY-GKDIKDIPQSMLR----LVKNP 509
            ||.             ..||.:       ::.:.||::|... .|:||...:.:|.    |::||
Mouse   317 LPG-------------ANKLRL-------EKRKEPPRIDRRLKDKEIKPNLKGVLHATWCLLRNP 361

  Fly   510 VYIVTCLGACMELMIVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVPGACIGIFLGGCILKRFQ 574
            :.:........|.|.......:||.||:||..:....|.:.||...:||..||.|:||.|:.:.|
Mouse   362 LVLTQIFCKVTESMTFKASSHYLPLYLQTQSVMTPRSAGMLTGMFILPGCIIGRFVGGYIVDKLQ 426

  Fly   575 LKPKGAVQFVLITNVICLACYAMLFFLGCDNLKMAGTTIPYYTSNKHGSTLEQPFQVNLTAACNF 639
            :..|..::|::..:|:.:..:.:|..:.|:..|.:|....|......||         |||.||.
Mouse   427 MSIKNKLKFIITVSVVSIMLFLLLISVECETAKFSGINEDYDGLGMIGS---------LTAPCNA 482

  Fly   640 GCECLTSEVEPVCGNNGLTYFSPCHAGCTAFSSTSNTN-YTNCACVRANISSSIYRGAGGSQAQA 703
            .|.|.||....|||.:.:.|||||.|||.|........ :.||:|::..::|.      ..:.|.
Mouse   483 KCGCTTSAYNSVCGRDDVQYFSPCFAGCHASKHLRKEKVFYNCSCIKEGLTSP------DGEGQY 541

  Fly   704 LSANENFAEVTVVPVATAGPCATPCRTIYPFLILLFFMTFLVASTQMPLLMIVLRSVSEEERSFA 768
            :.             |.:|.|.:.|.::..|....|..|.......:|.|||::.||.....|.:
Mouse   542 ID-------------AVSGTCNSNCLSLPLFFAFYFSATVFSNLCSIPALMIIVESVPTSWNSMS 593

  Fly   769 LGMQFVIFRLFGYIPAPILFGNLIDSTCILWK-SSCGEKGGRCLIYDIEKFRYKYVGLCASVKLI 832
            ||:.:.|:|..|.|||||.|.......|..|. ..||.| .||.||..::..|.:|.:..|:::.
Mouse   594 LGVMYTIWRFIGAIPAPIFFAETSALCCSFWDIDECGIK-VRCWIYKKKQLAYTFVAIWISMQVA 657

  Fly   833 A--LVIFMV 839
            .  |.|:.|
Mouse   658 TSLLCIYAV 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp30B	NP_609293.2	OATP	171..818	CDD:281175	167/664 (25%)
		MFS	174..>433	CDD:119392	62/269 (23%)
		MFS	512..>600	CDD:304372	24/87 (28%)
		KAZAL_SLC21	633..684	CDD:238650	23/51 (45%)
Gm7133	XP_986805.2	MFS	83..583	CDD:391944	145/605 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123298at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010