DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp30B and LOC556735

DIOPT Version :9

Sequence 1:	NP_609293.2	Gene:	Oatp30B / 34268	FlyBaseID:	FBgn0032123	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	XP_684701.3	Gene:	LOC556735 / 556735	-ID:	-	Length:	859	Species:	Danio rerio

Alignment Length:	733	Identity:	266/733 - (36%)
Similarity:	416/733 - (56%)	Gaps:	87/733 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 YGIQRFARI-----KIFVVLLSLLVMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGN 220
            :.::::.|:     :.|:..:..|..:|..:.|||::|||||||||:.:.||.|||:.|.::||:
Zfish   128 FPVRKYLRVILSDSRCFLFCMCYLTFIQSLMVSGYLSSVITTIEKRYSLRSSESGLLVSCFDIGS 192

  Fly   221 VITVIFVSYLGSRRHIPVWIGIGAVIMGIGSLVFMVPHFTGEP-----------NPGIAI-VNKT 273
            ::.|:|:||.|.|...|.|:.:|.|.:.:|:.:|.:|||...|           |.|:.: .|::
Zfish   193 LLVVVFISYFGGRGQRPRWLAVGGVFIAVGAALFSLPHFISPPYQIKEVNSSMGNEGLCLNGNRS 257

  Fly   274 SDNICKSALVRDQDMDLGRLSSGLSNQPLAPHTLREDNCLEGKASTTGPVLLFVLAQLLLGCGGS 338
            .|.:..|:..|||:.:              .|::.              |.|||.||:|:|.|.:
Zfish   258 RDALDVSSCPRDQEGN--------------DHSIY--------------VALFVCAQVLVGMGST 294

  Fly   339 PLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMDSLSSTTISITPGDRR 403
            |::|||.||:||:|:.|::|:|:..||.|||.||..|:|||..|:.|::|  ..|.::|...|.|
Zfish   295 PIYTLGPTYLDDNVKKENASLYLAIMYVMGALGPAAGYLLGGVLIGFYVD--PKTIVNIEQSDPR 357

  Fly   404 WVGMWWGGFLLCGVILLVVAVPFFSFPKVL-AREKKKIRKSSVVQPVLPNNSRATVATDEMGKVK 467
            :||.||.|||||...:|:|..|.|:|||.| .|.|||.:|.:.        ..|:...|::.|.|
Zfish   358 FVGNWWSGFLLCAFAMLLVIFPMFTFPKKLPPRHKKKKKKHAA--------DSASNDDDDVLKEK 414

  Fly   468 KLEIVAVTSKEDQSQAPPKVDTGYGKDIKDIPQSMLRLVKNPVYIVTCLGACMELMIVSGFVVFL 532
                   ::.:.|:.|.   ..|:|:||||:|::.:|::.|..::...|....|..||:.|:.|:
Zfish   415 -------SNSKGQTVAS---SMGFGRDIKDLPKAAIRILSNMTFLFVSLSYTAESAIVTAFITFI 469

  Fly   533 PKYLETQFSLGKSQANIFTGSIAVPGACIGIFLGGCILKRFQLKPKGAVQFVLITNVICLACYAM 597
            ||::|:||.:..|.|:|:||.|.||.|.:||.|||.|:|:.:|..:.:.:..:|.:.:.|.|::.
Zfish   470 PKFIESQFGIPASNASIYTGVIIVPSAGVGIVLGGYIIKKLKLGARESAKLAMICSGVSLLCFST 534

  Fly   598 LFFLGCDNLKMAGTTIPYYTSNKHGSTLEQPFQVNLTAACNFGCECLTSEVEPVCGNNGLTYFSP 662
            ||.:||:::.:.|..|||.|    |.||....: |||..||..|.|..:|..||||::|:|||:|
Zfish   535 LFIVGCESINLGGINIPYTT----GPTLTLTHR-NLTGGCNVNCGCRINEYAPVCGSDGITYFNP 594

  Fly   663 CHAGCTAF--SSTSNTNYTNCACVRANISSSIYRGAGGSQAQALSA----NENFAEVTVVPVATA 721
            |.|||:..  .||...|||:||||::....:......|:|.|.:..    |||       ..|.:
Zfish   595 CLAGCSTVGNDSTGIRNYTDCACVQSRQVITPPTSGQGNQLQLVIVKTYLNEN-------GFALS 652

  Fly   722 GPCATPCRTIYPFLILLFFMTFLVASTQMPLLMIVLRSVSEEERSFALGMQFVIFRLFGYIPAPI 786
            |.|...|.|:.||||.||.:|.:.|..|...:::.||||.|:||.||||||||:.|...|||.||
Zfish   653 GKCDRTCNTLIPFLIFLFIVTLITACAQPSAIIVTLRSVDEQERPFALGMQFVLLRTLAYIPTPI 717

  Fly   787 LFGNLIDSTCILWKSSCGEKGGRCLIYDIEKFRYKYVGLCASVKLIALVIFMVDWWLVRRRKQLE 851
            .||.:||:||:||:..||..|. |..||:..||:.|.||.||:|.:..:...:.|:.::.::  :
Zfish   718 YFGAVIDTTCMLWQQDCGIHGS-CWEYDVTSFRFVYFGLAASLKFVGFIFIFLTWYSIKYKE--D 779

  Fly   852 KMKPLNASDPIIGSIISL 869
            ::|......|.:|::..|
Zfish   780 RLKRWQQHLPPLGTVSEL 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp30B	NP_609293.2	OATP	171..818	CDD:281175	252/665 (38%)
		MFS	174..>433	CDD:119392	102/270 (38%)
		MFS	512..>600	CDD:304372	32/87 (37%)
		KAZAL_SLC21	633..684	CDD:238650	27/52 (52%)
LOC556735	XP_684701.3	OATP	143..748	CDD:281175	252/665 (38%)
		MFS	146..>545	CDD:119392	158/446 (35%)
		KAZAL_SLC21	565..619	CDD:238650	28/53 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578739
Domainoid	1	1.000	457	1.000	Domainoid score	I476
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H57135
Inparanoid	1	1.050	483	1.000	Inparanoid score	I1411
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123298at33208
OrthoFinder	1	1.000	-	-		FOG0007263
OrthoInspector	1	1.000	-	-		oto40128
orthoMCL	1	0.900	-	-		OOG6_101062
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X98
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.700