DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp30B and Slco4c1

DIOPT Version :9

Sequence 1:	NP_609293.2	Gene:	Oatp30B / 34268	FlyBaseID:	FBgn0032123	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_001002024.2	Gene:	Slco4c1 / 432363	RGDID:	1303048	Length:	724	Species:	Rattus norvegicus

Alignment Length:	780	Identity:	258/780 - (33%)
Similarity:	384/780 - (49%)	Gaps:	148/780 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 GDQLPSTVGSGP-----GGGGPSAVADSVTVKCHSRQASAGKCPADPEED--------------- 142
            |.:.|:.|.|.|     ....||.|..|...   ||..:.|..|.:.|:.
  Rat     6 GVENPAFVPSSPDTPRRASASPSQVEVSAVA---SRNQNGGSQPRESEDPQKSTEPSPPSSTLPA 67

  Fly   143 FDE------EQFRSGDCGILNCRPYGIQRFARIKIFVVLLSLLVMMQQALSSGYINSVITTIEKR 201
            .||      .:...|.||..|..|..:||....|.|::...||.:.|..:.:|.:|..|:|||||
  Rat    68 SDEPPGSQLSELEEGPCGWRNFHPQCLQRCNNPKGFLLHYCLLALTQGIVVNGLVNISISTIEKR 132

  Fly   202 FEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIMGIGSLVFMVPHFTGEPNPG 266
            :|:.||.:|||:|||:|...:..:|||:.|.|.|.|.|:...:.::|:|:|||.:|||..
  Rat   133 YEMKSSLTGLISSSYDISFCVLSLFVSFFGERGHKPRWLAFASFMIGLGALVFSLPHFFS----- 192

  Fly   267 IAIVNKTSDNICKSALVRDQDMDLGRLSSGLSNQPLAPHTLREDNCLEGK----ASTTGPV---- 323
                                    ||...|         |:.||.||...    ||:|..:
  Rat   193 ------------------------GRYELG---------TIFEDTCLTRNSTRCASSTSLLSNYF 224

  Fly   324 LLFVLAQLLLGCGGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMD 388
            .:|||.|||||.||:||:||||.::||.|.|..||:|||..|||...||.:|::||..||:.::|
  Rat   225 YVFVLGQLLLGTGGTPLYTLGTAFIDDSVPTHKSSLYIGIGYSMSILGPAIGYVLGGQLLTMYID 289

  Fly   389 SLSSTTISITPGDRRWVGMWWGGFLLCGVILLVVAVPFFSFPKVLAREKKKIRKSSVVQPVLPNN 453
            .....:..:|..|.||:|.||.||||..:....:.:||..|||                 .||..
  Rat   290 VAMGQSSDLTEDDPRWLGAWWIGFLLAWLFAWSLIMPFSCFPK-----------------HLPGT 337

  Fly   454 SRATVATDEMGKVKKLEIVAVTSKEDQSQAPPKVDTGYGKDIKDIPQSMLRLVKNPVYIVTCLGA 518
            ::.     :.||..:       :.::.|.:...:|..:||.|||.|.::..|::|.|:|...|..
  Rat   338 AKI-----QAGKTSQ-------THQNNSTSFQHMDENFGKSIKDFPTAVKNLMRNTVFICLVLST 390

  Fly   519 CMELMIVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVPGACIGIFLGGCILKRFQLKPKGAVQF 583
            ..|.::.:||..||||::|.||.|..|.|....|::.:|||.:|..|||.::.:|::|.|..::|
  Rat   391 TSEALVTTGFATFLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGVLVSKFKMKCKNTMKF 455

  Fly   584 VLITNVICLACYAMLFFLGCDNLKMAGTTIPYYTSNKHGSTLEQPFQVNLTAACNFGCECLTSEV 648
            .|.|:.:.|....:..:..|:|...||.:..|..:.:.|         ||||.||..|.||.|..
  Rat   456 ALCTSGVALMLSFVFIYAKCENGPFAGVSESYNGTGEMG---------NLTAPCNANCNCLRSYY 511

  Fly   649 EPVCGNNGLTYFSPCHAGCTAFSSTSNTN---YTNCACV--RANISSSIYRGAGGSQAQALSANE 708
            .|:||::|:.|||||.|||  .:|.||..   |.||:|:  :.:|:|:             :.:.
  Rat   512 YPLCGSDGVQYFSPCFAGC--LNSVSNRKPKAYYNCSCIERKVDITST-------------AESP 561

  Fly   709 NFAEVTVVPVATAGPCATPCRTIYPFLILLFFMTFL---VASTQMPLLMIVLRSVSEEERSFALG 770
            :|.       |.||.|.|.|..: |..:.:||:|.:   :|.|  |:.:.:||.|:..:||.|||
  Rat   562 DFE-------ARAGKCKTQCSNL-PIFLGIFFITVIFTFMAGT--PITVSILRCVNHRQRSLALG 616

  Fly   771 MQFVIFRLFGYIPAPILFGNLIDSTCILWK-SSCGEKGGRCLIYDIEKFRYKYVGLCASVKLIAL 834
            :||::.||.|.||.||:||..|||||:||. :.||.||. |.|||..:..:..|.:..:.|:|.:
  Rat   617 VQFMLLRLLGTIPGPIIFGVTIDSTCVLWDINECGTKGA-CWIYDNIRMAHMLVAISVTCKVITI 680

Fly 835 834
Rat 681 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp30B	NP_609293.2	OATP	171..818	CDD:281175	231/663 (35%)
		MFS	174..>433	CDD:119392	100/266 (38%)
		MFS	512..>600	CDD:304372	30/87 (34%)
		KAZAL_SLC21	633..684	CDD:238650	27/53 (51%)
Slco4c1	NP_001002024.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..81		16/77 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123298at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101062
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X98
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720