DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp30B and slco1f1

DIOPT Version :9

Sequence 1:	NP_609293.2	Gene:	Oatp30B / 34268	FlyBaseID:	FBgn0032123	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	XP_017210475.1	Gene:	slco1f1 / 405853	ZFINID:	ZDB-GENE-040426-2192	Length:	638	Species:	Danio rerio

Alignment Length:	728	Identity:	228/728 - (31%)
Similarity:	348/728 - (47%)	Gaps:	125/728 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 EQFRSGDCGILNCRPYGIQRFARIKIFVVLLSLLVMMQQALSSGYINSVITTIEKRFEIPSSYSG 210
            |:..|..|    |.|       |:|||:..|: .....:::::.|..|.||.|||||||.||..|
Zfish    15 EKASSTTC----CSP-------RLKIFICALA-FCYFSKSMTASYTKSTITQIEKRFEITSSTVG 67

  Fly   211 LIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIMGIGSLVFMVPHF-TGEPNPGIAIV---- 270
            .|..|:|:||::.:..|||:|::.|.|..||.|.::||||:|:...||| .|....|.|..
Zfish    68 FIDGSFEMGNMLVITLVSYVGAKFHRPKIIGAGVLLMGIGTLLMASPHFLMGRYKYGTAATHTND 132

  Fly   271 --NKTSDNICKSALVRDQDMDLGRLSSGLSNQPLAPHTLREDNCLEGKASTTGPVLLFVLAQLLL 333
              |.|..:.|.|    |....|        .||.:     |...:|.::|....|:|  |...:.
Zfish   133 AGNFTVISTCSS----DSQETL--------QQPYS-----ECQIIEAESSLLWVVVL--LGNAMR 178

  Fly   334 GCGGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHM--DSLSSTTIS 396
            |.|.:.:..||.:::||:.|.|:|:.|||.:.::...||:.||:||:...:.::  |.::..:::
Zfish   179 GIGEASIVPLGMSFIDDYARPENSAFYIGCLNTLRGIGPIFGFILGSLCANLYVDFDLVNQESVT 243

  Fly   397 ITPGDRRWVGMWWGGFLLCGVILLVVAVPFFSFPKVLAREKKKIRKSSVVQPVLPNNSRATVATD 461
            |||.|.||||.||.||::.|::.|:.|.||:..|:                 .||.||:
Zfish   244 ITPQDSRWVGAWWLGFVVSGLLTLLAAFPFWFLPR-----------------ALPENSQ------ 285

  Fly   462 EMGKVKKLEIVAVTSKEDQSQAPPKVDTGYGKDIKDIPQSMLRLVKNPVYIVTCLGACMELMIVS 526
                         ||:.|......|......:.|||...:..||:.|.:||   |.....::..:
Zfish   286 -------------TSELDHPSEQHKTTPSLTEIIKDFAPTFKRLLTNKIYI---LYLAYSIVAFN 334

  Fly   527 GFVV---FLPKYLETQFSLGKSQANIFTGSIAVPGACIGIFLGGCILKRFQLKPKGAVQFVLITN 588
            .|.:   :.|||||.||....|:||...|...:|...:||||.|.::|||:.....:.:..|.|.
Zfish   335 DFAIVATYTPKYLEQQFGQSASKANFLIGVTCIPAVALGIFLSGLMMKRFKWGLLASARVNLFTG 399

  Fly   589 VICLACYAMLFFLGCDNLKMAGTTIPYYTSNKHGSTLEQPFQVNLTAACNFGCECLTSEVEPVCG 653
            |..|......|.|.|:||.:||.|:||     .|||..|....::..:||..|.|...:.:||||
Zfish   400 VTMLLLAVPFFALSCENLDVAGVTVPY-----QGSTEVQGVISDVLPSCNADCGCPDLQWDPVCG 459

  Fly   654 NNGLTYFSPCHAGCTAFSSTS-NTNYTNCACVRANISSSIYRGAGGSQAQALSANENFAEVTVVP 717
            .||:||.|||||||.:..... |..:.:|.|:               |:..||...:
Zfish   460 ENGVTYISPCHAGCNSTQGAGWNKTFHDCRCI---------------QSWGLSVGNS-------- 501

  Fly   718 VATAGPCATP--C-RTIYPFLILLFFMTFLVASTQMPLLMIVLRSVSEEERSFALGMQFVIFRLF 779
            .|..|.|:..  | :.||.||.:...:.|:.:...:|.|...:|.|..|.::.::|:..:..|:.
Zfish   502 SAVLGQCSRDPNCNQMIYVFLGVQSLVLFVYSLGAVPFLTFSMRIVDPEMKALSVGVLLLSIRVL 566

  Fly   780 GYIPAPILFGNLIDSTCILW--KSSCGEKGGRCLIYDIEKFRYKYVGLCASVKLIALVIFMVDWW 842
            |.|||||.||.|||:||:.|  :.|||.  |.|.|||.|.||:.:.|:...::::|..:.    |
Zfish   567 GGIPAPIYFGGLIDTTCLKWGQRKSCGR--GACRIYDNETFRFLFQGMTIGLRVLACSVL----W 625

  Fly   843 LVR---RRKQLEK 852
            :..   :||..|:
Zfish   626 IATIEIKRKSAEQ 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp30B	NP_609293.2	OATP	171..818	CDD:281175	213/664 (32%)
		MFS	174..>433	CDD:119392	91/267 (34%)
		MFS	512..>600	CDD:304372	27/90 (30%)
		KAZAL_SLC21	633..684	CDD:238650	21/51 (41%)
slco1f1	XP_017210475.1	OATP	29..605	CDD:281175	213/664 (32%)
		MFS	31..>413	CDD:119392	134/440 (30%)
		KAZAL_SLC21	440..492	CDD:238650	22/66 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910