DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp30B and Oatp58Dc

DIOPT Version :9

Sequence 1:	NP_609293.2	Gene:	Oatp30B / 34268	FlyBaseID:	FBgn0032123	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_001097409.1	Gene:	Oatp58Dc / 37545	FlyBaseID:	FBgn0034716	Length:	789	Species:	Drosophila melanogaster

Alignment Length:	822	Identity:	211/822 - (25%)
Similarity:	362/822 - (44%)	Gaps:	121/822 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 HRRQESMYQMTGLYSETNSGDDSSIDAALDHDSQPHATSYLAGDQ-----LPSTVGSGPGGGGPS 115
            |.|:||.             |:|.:::.|.::.:.:.....||:|     .|.|        |.|
  Fly    19 HGRRESR-------------DESDVESRLLNNGKSYDKEKEAGNQDGEETTPKT--------GKS 62

  Fly   116 AVADSVTVKCHSRQASAGKCPAD-PEEDFDEEQFRSGDCGILNCRPYGIQRFARIKIFVVLLSLL 179
            ......:.:.....|...|..|: |.|       ::..||....:....||||....:|:|..::
  Fly    63 KKKKQKSEQDRLMTAEINKLLAESPLE-------KNVTCGFWIFKGTFYQRFANQTAYVLLYGIV 120

  Fly   180 VMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGA 244
            ..: .:::..|.|..||||||||:|||..:|:|:...:|...:....::|...:.|.|.|||.|.
  Fly   121 GCI-FSMTYAYFNGTITTIEKRFKIPSKNTGIISVGNDISQTLVSAVLAYYAGKGHRPRWIGFGL 184

  Fly   245 VIMGIGSLVFMVPHFT-GEPNPGIAIVNK----TSDNICKSALVRDQDMDLGRLSSGLSNQPLAP 304
            :.:....::...|||. |.....:|:.::    ..:|....|:...:...|.||:.|.:
  Fly   185 LTIVFFCILTTAPHFLYGPGEDALALTSEFGGMPDENATMEAIEEQRSKTLCRLNGGGA------ 243

  Fly   305 HTLREDNCLEGKASTTGPVLLFVLAQLLLGCGGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGA 369
                  .|..|:.:....:|||| ||.:.|.|||..:|||.:|:||:.:...:...:...|.:..
  Fly   244 ------ECEVGEGNFAPQLLLFV-AQFISGIGGSLYYTLGVSYMDDNTKKSKTPALLSLSYFLRM 301

  Fly   370 FGPVVGFLLGAYLLSFHMDSLSSTTISITPGDRRWVGMWWGGFLLCGVILLVVAVPFFSFPKVLA 434
            .||.:|:.|.::.|..::.......|:  ..|.||:|.||.|:|:.|.:|....|....|||.|.
  Fly   302 LGPAIGYALASFCLRLYIAPQMHPVIN--NKDPRWLGAWWLGWLVMGGLLSFSGVFLSMFPKELP 364

  Fly   435 REKKKIRKSSVVQPVLPNNSRATVATDEMGKVKKLEIVAVTSKEDQSQAPPKVDTGYGKDIKDIP 499
            |        :|.:..:..|.|   ...|...||..|...:|::.||     |.........:|:.
  Fly   365 R--------AVARRKVEENRR---REKERLSVKSTEKERLTAELDQ-----KTTAEAKASFQDML 413

  Fly   500 QSMLRLVKNPVYIVTCLGACMELMIVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVPGACIGIF 564
            ::..||:.|..|:...|.:...|:..:.:.:|.|||:|.|:....:.:::.||::|:..:.:|:.
  Fly   414 KTFRRLITNKTYMCNTLSSIFYLVGYTPYWIFTPKYIEVQYRQSAATSSMVTGTVALAFSAVGVL 478

  Fly   565 LGGCILKRFQLKPKG--------AVQFVLITNVICLACYAMLFFLGCDNLKMAGTTIPYYTSNKH 621
            |.|.|:.|:  ||:.        .|.|:.:..::..|      |:||...:.:      ...|.|
  Fly   479 LSGFIISRY--KPRARYMAAWNVIVGFLTVAGILAYA------FIGCPGNESS------VIVNIH 529

  Fly   622 GSTLEQPFQVNLTAACNFGCECLTSEVEPVCGNNGLTYFSPCHAGCTAF--SSTSNTNYTNCACV 684
            .|:|     ...|..||..|.|......||||.|.:||.|.|||||...  :|.....:.:|:|:
  Fly   530 DSSL-----AGNTTTCNSACSCDYVRYSPVCGENNMTYISACHAGCKKLLVNSEGKKIFYDCSCI 589

  Fly   685 RANISSSIYRGAGGSQAQALS----ANENFAEVTVV---------PVATAGPCATPCRTIY-PFL 735
            .::.:     |...||.:.|:    :|:..::.|.|         ..|..|.|...|.|.: .||
  Fly   590 PSDDA-----GNSTSQFKRLTSFDLSNDEVSQNTSVHSQLEALANGQAMPGACPVNCWTQFVAFL 649

  Fly   736 ILLFFMTFLVASTQMPLLMIVLRSVSEEERSFALGMQFVIFRLFGYIPAPILFGNLIDSTCILWK 800
            .::..:.|:.||.:....::.:|.|.|::::.|:|....:..:..:||:||.||.:.|..|::|.
  Fly   650 AVMCCLKFVGASGRASNFLVSVRCVPEKDKTAAMGFGMTLCSMLAFIPSPIFFGWVFDRVCLVWG 714

  Fly   801 SSCGEKGGRCLIYDIEKFRYKYVGLCASVKLIALVIFMVDWW 842
            .:|..| |.|.:||....||. :...|:|.:....||.:..|
  Fly   715 KTCTNK-GNCWLYDPLSMRYT-LNFTAAVFIAIGAIFDLGVW 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp30B	NP_609293.2	OATP	171..818	CDD:281175	179/675 (27%)
		MFS	174..>433	CDD:119392	74/263 (28%)
		MFS	512..>600	CDD:304372	21/95 (22%)
		KAZAL_SLC21	633..684	CDD:238650	20/52 (38%)
Oatp58Dc	NP_001097409.1	OATP	112..731	CDD:281175	179/675 (27%)
		MFS	114..>518	CDD:119392	116/443 (26%)
		KAZAL_SLC21	537..590	CDD:238650	21/52 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446219
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11388
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840