DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp30B and SLCO4C1

DIOPT Version :9

Sequence 1:	NP_609293.2	Gene:	Oatp30B / 34268	FlyBaseID:	FBgn0032123	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_851322.3	Gene:	SLCO4C1 / 353189	HGNCID:	23612	Length:	724	Species:	Homo sapiens

Alignment Length:	770	Identity:	251/770 - (32%)
Similarity:	364/770 - (47%)	Gaps:	122/770 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 SGDDSSID-AALDHD-----SQPHATSYLAGDQLPSTVGSGPGGGGPSAVADSVTVKCHSRQASA 132
            |...|.|: :||..|     |||...      |.|......|....|||..:....|..|...|
Human    24 SASPSQIEVSALSSDPQRENSQPQEL------QKPQEPQKSPEPSLPSAPPNVSEEKLRSLSLS- 81

  Fly   133 GKCPADPEEDFDEEQFRSGDCGILNCRPYGIQRFARIKIFVVLLSLLVMMQQALSSGYINSVITT 197
                          :|..|..|..|..|..:||......|::...||.:.|..:.:|.:|..|:|
Human    82 --------------EFEEGSYGWRNFHPQCLQRCNTPGGFLLHYCLLAVTQGIVVNGLVNISIST 132

  Fly   198 IEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIMGIGSLVFMVPH-FTG 261
            :|||:|:.||.:|||:|||:|...:..:|||:.|.|.|.|.|:...|.::|:|:|||.:|. |:|
Human   133 VEKRYEMKSSLTGLISSSYDISFCLLSLFVSFFGERGHKPRWLAFAAFMIGLGALVFSLPQFFSG 197

  Fly   262 EPNPGIAIVNKTSDNICKSALVRDQDMDLGRLSSGLSNQPLAPHTLREDNCLEGKASTTGPVLLF 326
            |...|     ...::.|.:                         |....:|....:|.:..:.:|
Human   198 EYKLG-----SLFEDTCVT-------------------------TRNSTSCTSSTSSLSNYLYVF 232

  Fly   327 VLAQLLLGCGGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMDSLS 391
            :|.|||||.||:||:||||.::||.|.|..||:|||..|:|...||.:|::||..||:.::|...
Human   233 ILGQLLLGAGGTPLYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYIDVAM 297

  Fly   392 STTISITPGDRRWVGMWWGGFLLCGVILLVVAVPFFSFPKVLAREKKKIRKSSVVQPVLPNNSRA 456
            ..:..:|..|.||:|.||.||||..:....:.:||..|||                 .||.
Human   298 GESTDVTEDDPRWLGAWWIGFLLSWIFAWSLIIPFSCFPK-----------------HLPG---- 341

  Fly   457 TVATDEMGKVKKLEIVAVTSKEDQSQAPPKVDTGYGKDIKDIPQSMLRLVKNPVYIVTCLGACME 521
             .|..:.||         ||:..||.:  ..|..:||.|||.|.::..|:||.|::...|....|
Human   342 -TAEIQAGK---------TSQAHQSNS--NADVKFGKSIKDFPAALKNLMKNAVFMCLVLSTSSE 394

  Fly   522 LMIVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVPGACIGIFLGGCILKRFQLKPKGAVQFVLI 586
            .:|.:||..||||::|.||.|..|.|....|::.:|||.:|..|||.::.:|::..|..::|.|.
Human   395 ALITTGFATFLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGFLVSKFRMTCKNTMKFALF 459

  Fly   587 TNVICLACYAMLFFLGCDNLKMAGTTIPYYTSNKHGSTLEQPFQVNLTAACNFGCECLTSEVEPV 651
            |:.:.|....:..:..|:|...||.:..|..:.:.|         ||.|.||..|.|..|...||
Human   460 TSGVALTLSFVFMYAKCENEPFAGVSESYNGTGELG---------NLIAPCNANCNCSRSYYYPV 515

  Fly   652 CGNNGLTYFSPCHAGCT-AFSSTSNTNYTNCACVRANISSSIYRGAGGSQAQALSANENFAEVTV 715
            || :|:.|||||.|||: ..:......|.||:|:.             .:.:..|..|.|..
Human   516 CG-DGVQYFSPCFAGCSNPVAHRKPKVYYNCSCIE-------------RKTEITSTAETFGF--- 563

  Fly   716 VPVATAGPCATPCRTIYPFLILLFFMTFLVASTQMPLLMIVLRSVSEEERSFALGMQFVIFRLFG 780
              .|.||.|.|.|..:..||.:.|.:.........|:.:.:||.|:..:||.|||:||::.||.|
Human   564 --EAKAGKCETHCAKLPIFLCIFFIVIIFTFMAGTPITVSILRCVNHRQRSLALGIQFMVLRLLG 626

  Fly   781 YIPAPILFGNLIDSTCILWK-SSCGEKGGRCLIYDIEKFRYKYVGLCASVKLIAL 834
            .||.||:||..||||||||. :.||.||. |.|||..|..:..|.:..:.|:|.:
Human   627 TIPGPIIFGFTIDSTCILWDINDCGIKGA-CWIYDNIKMAHMLVAISVTCKVITM 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp30B	NP_609293.2	OATP	171..818	CDD:281175	222/649 (34%)
		MFS	174..>433	CDD:119392	93/259 (36%)
		MFS	512..>600	CDD:304372	29/87 (33%)
		KAZAL_SLC21	633..684	CDD:238650	23/51 (45%)
SLCO4C1	NP_851322.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..71		13/46 (28%)
		OATP	106..664	CDD:281175	222/649 (34%)
		MFS	124..>485	CDD:119392	143/423 (34%)
		KAZAL_SLC21	499..549	CDD:238650	23/50 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123298at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101062
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X98
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.720