DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp30B and slco1d1

DIOPT Version :9

Sequence 1:	NP_609293.2	Gene:	Oatp30B / 34268	FlyBaseID:	FBgn0032123	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_001335015.1	Gene:	slco1d1 / 326845	ZFINID:	ZDB-GENE-030131-5044	Length:	689	Species:	Danio rerio

Alignment Length:	745	Identity:	223/745 - (29%)
Similarity:	353/745 - (47%)	Gaps:	126/745 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 ARIKIFVVLLSLLVMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLG 231
            :::|:|:..: ..|...:|....|:.|.:|.||:||::|||..|.|..|:||||:..:.||||.|
Zfish    12 SKLKMFLAAM-CFVFFAKAFQGSYMKSSVTQIERRFDVPSSLIGFIDGSFEIGNLFVIAFVSYFG 75

  Fly   232 SRRHIPVWIGIGAVIMGIGSLVFMVPH-FTGEPNPGIAI------VNKTSDNI--CKSALVRDQD 287
            ::.|.|..|..|.::|..||.:..:|| |.|:......|      ||.| :|:  |.:.....||
Zfish    76 AKLHRPRLIAAGCLVMSAGSFITAMPHFFQGQYKYESTISHFSASVNGT-ENVLPCLTNASLAQD 139

  Fly   288 MDLGRLSSGLSNQPLAPHTLREDNCLEGKASTTGPVLLFVLAQLLLGCGGSPLFTLGTTYVDDHV 352
            .::..:.|             :..|  .|||::...|...|..:|.|.|.:|:..||.:|:||..
Zfish   140 SEIPTVES-------------QAEC--EKASSSSLWLFVFLGNMLRGIGETPVMPLGLSYLDDFS 189

  Fly   353 RTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMD--SLSSTTISITPGDRRWVGMWWGGFLLC 415
            |.|:::.|:..:.::|..||:.||:||::....::|  ::...:|:|...|.||||.||.|||:.
Zfish   190 REENTAFYLALIQTVGIMGPMFGFMLGSFCAKLYVDIGTVDLDSITINYKDSRWVGAWWLGFLVT 254

  Fly   416 GVILLVVAVPFFSFPKVLAR------EKKK-IRKSSVVQPVLPNNSRATVATDEMGKVKKLEIVA 473
            |.::|:..:||:..||.|.|      |||. ..:....:..:|:|::
Zfish   255 GGVMLLAGIPFWFLPKSLTRQGEPESEKKPGAPEGGEQERFIPDNNK------------------ 301

  Fly   474 VTSKEDQSQAPPKVDTGYGKDIKDIPQSMLRLVKNPVYIVTCLGACMELMIVSGF---VVFLPKY 535
              .....|:..|...:...||.  :| |:.:|..|.:|:   |..|..|:.||||   :.|.||:
Zfish   302 --HNPPASKPAPVTMSALAKDF--LP-SLKKLFSNTIYV---LLVCTGLIQVSGFIGMITFKPKF 358

  Fly   536 LETQFSLGKSQANIFTGSIAVPGACIGIFLGGCILKRFQLKPKGAVQFVLITNVICLACYAMLFF 600
            :|..:....|:|....|.:.:|...:||..||.|:|||::...||.:..::.:|:......:.:|
Zfish   359 MEQVYGQSASRAIFLIGIMNLPAVALGIVTGGFIMKRFKVNVLGAAKICIVASVLAFCSMLIQYF 423

  Fly   601 LGCDNLKMAGTTIPYYTSNKHGSTLEQPFQV-NLTAACNFGCECLTSEVEPVCGNNGLTYFSPCH 664
            |.|||.::||.|:.|     .|:. |..:|. .|.:.||.||.|.....:|:|.:||:||.|||.
Zfish   424 LQCDNSQVAGLTVTY-----QGAP-EVSYQTETLISQCNIGCSCSLKHWDPICASNGVTYTSPCL 482

  Fly   665 AGC-TAFSSTSNTNYTNCACVRANISSSIYRGAGGSQAQALSANENFAEVTVVPVATAGPCATPC 728
            ||| |:........:.||:|:                .:||....|.:       |..|.|  |.
Zfish   483 AGCQTSTGIGKEMVFHNCSCI----------------GEALLPYTNMS-------AVLGQC--PR 522

  Fly   729 RTIYPFLILLFFM-----TFLVASTQMPLLMIVLRSVSEEERSFALGMQFVIFRLFGYIPAPILF 788
            ::...|:..::..     .|..|....|..:|:|||::.|.:|.||||..:|.|..|.||.||.|
Zfish   523 KSDCDFMFKIYMAVTVIGAFFSAVGATPGYIILLRSITPELKSLALGMHTLIVRTLGGIPPPIYF 587

  Fly   789 GNLIDSTCILW-KSSCGEKGGRCLIYDIEKFRYKYVGLCASVKLIALVIFMVDWWLVRRRKQLEK 852
            |.|||.||:.| ...||.:|. |.|||...||..::||..::...:.::|.:   |..|....||
Zfish   588 GALIDKTCLKWGLKQCGGRGA-CRIYDSGAFRNAFLGLIYALYSSSYLLFGL---LYNRLSHREK 648

  Fly   853 MKPL-------------------NASDPII 863
            .:.|                   |||..|:
Zfish   649 KQALKDQLKAPEQDSCGVSTTNGNASSAIV 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp30B	NP_609293.2	OATP	171..818	CDD:281175	208/675 (31%)
		MFS	174..>433	CDD:119392	88/269 (33%)
		MFS	512..>600	CDD:304372	26/90 (29%)
		KAZAL_SLC21	633..684	CDD:238650	21/51 (41%)
slco1d1	NP_001335015.1	OATP	16..617	CDD:308646	208/675 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X98
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910